Detailed information for compound 1894690

Basic information

Technical information
  • TDR Targets ID: 1894690
  • Name: 4-tert-butyl-N-methylpyrimidin-2-amine
  • MW: 165.235 | Formula: C9H15N3
  • H donors: 1 H acceptors: 2 LogP: 2.23 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1nccc(n1)C(C)(C)C
  • InChi: 1S/C9H15N3/c1-9(2,3)7-5-6-11-8(10-4)12-7/h5-6H,1-4H3,(H,10,11,12)
  • InChiKey: OPONOUWWINSCIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-tert-butyl-N-methyl-pyrimidin-2-amine
  • 4-tert-butyl-N-methyl-2-pyrimidinamine
  • (4-tert-butylpyrimidin-2-yl)-methyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0151 0.1213
Leishmania major DNA polymerase kappa, putative 0.0044 0.0187 1
Onchocerca volvulus 0.0028 0.0092 0.0449
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0029 0.0234
Schistosoma mansoni rotamase 0.0035 0.0132 0.1223
Brugia malayi Pre-SET motif family protein 0.0219 0.1241 1
Schistosoma mansoni hypothetical protein 0.0054 0.0249 0.2405
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0994
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0029 0.0261
Loa Loa (eye worm) hypothetical protein 0.0127 0.0687 0.5538
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0054 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0145 0.1431
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0151 0.1407
Schistosoma mansoni jun-related protein 0.0066 0.032 0.3126
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0029 0.0261
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.008 0.2518
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.0886
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Brugia malayi Bromodomain containing protein 0.0031 0.0106 0.076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0151 0.1407
Echinococcus multilocularis thyroid hormone receptor alpha 0.017 0.0949 0.9533
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0132 0.0918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0151 0.1213
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0012 0.0091
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0151 0.1213
Onchocerca volvulus 0.0028 0.0088 0.0419
Echinococcus granulosus GPCR family 2 0.0015 0.0012 0.0091
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.005 0.1343
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0151 0.1407
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0145 0.1082
Onchocerca volvulus 0.0031 0.011 0.058
Trichomonas vaginalis set domain proteins, putative 0.0249 0.1424 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0698 0.5623
Echinococcus granulosus bloom syndrome protein 0.0025 0.0073 0.0703
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0314 0.0265
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.005 0.0402
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0145 0.1082
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0029 0.0172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0994
Brugia malayi nuclear receptor RXR 0.002 0.0042 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0151 0.1126
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.011 0.1076
Schistosoma mansoni jumonji domain containing protein 0.008 0.0402 0.3962
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0151 0.1126
Echinococcus granulosus lamin 0.0028 0.0092 0.0892
Schistosoma mansoni hypothetical protein 0.0073 0.0359 0.3529
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0029 0.0137
Schistosoma mansoni lamin 0.0028 0.0092 0.0808
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0117 0.3699
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0151 0.1126
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0151 0.1407
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0178 0.1762
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0029 0.0261
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0012 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0151 0.1213
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.021 0.1611
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0145 0.0096
Trichomonas vaginalis DNA polymerase eta, putative 0.0065 0.0314 0.2194
Brugia malayi ecdysone receptor 0.0018 0.0029 0.0137
Echinococcus multilocularis dna polymerase eta 0.0037 0.0145 0.1431
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.005 0.2593
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0144 0.1424
Brugia malayi hypothetical protein 0.0026 0.008 0.0556
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.005 0.1539
Brugia malayi nuclear receptor RXR 0.0018 0.0029 0.0137
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0029 0.0137
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0412 0.4116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0151 0.1126
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.008 0.2518
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.008 0.2518
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0151 0.1486
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0314 1
Entamoeba histolytica hypothetical protein 0.0073 0.0359 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0012 0.0091
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0044 0.0187 0.0138
Trypanosoma brucei unspecified product 0.0026 0.0075 0.2357
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.1668 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.011 0.8333
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0012 0.0098
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0301
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0159 0.5035
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0713
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0145 0.1352
Loa Loa (eye worm) hypothetical protein 0.0037 0.0145 0.117
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.005 0.0471
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0145 0.117
Echinococcus granulosus expressed protein 0.0035 0.0132 0.1303
Brugia malayi jmjC domain containing protein 0.0037 0.0144 0.1076
Brugia malayi nuclear hormone receptor 0.0018 0.0029 0.0137
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0145 0.4591
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.1668 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0144 0.1345
Brugia malayi nuclear receptor NHR-67 0.0018 0.0029 0.0137
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0151 0.1486
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0187 0.5933
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0029 0.0261
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.005 0.0471
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0151 0.1486
Echinococcus granulosus jun protein 0.0081 0.0412 0.4116
Loa Loa (eye worm) hypothetical protein 0.0079 0.0398 0.3208
Loa Loa (eye worm) hypothetical protein 0.0028 0.0088 0.0705
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0151 0.1486
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0106 0.085
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0339
Brugia malayi jmjC domain containing protein 0.01 0.0526 0.4184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0029 0.0261
Schistosoma mansoni coup transcription factor 0.0038 0.0151 0.1407
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0151 0.1486
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0151 0.1126
Schistosoma mansoni ap endonuclease 0.0021 0.005 0.0384
Giardia lamblia DINP protein human, muc B family 0.0044 0.0187 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0314 1
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0073 0.0494
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0044 0.0187 1
Toxoplasma gondii exonuclease III APE 0.0021 0.005 0.2625
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0151 0.1486
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0151 0.0871
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0151 0.1486
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0029 0.0137
Leishmania major hypothetical protein, conserved 0.0026 0.008 0.4245
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Leishmania major DNA polymerase eta, putative 0.0037 0.0145 0.7738
Loa Loa (eye worm) hypothetical protein 0.0052 0.0238 0.1915
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0128 0.3514
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0145 0.4008
Echinococcus multilocularis geminin 0.0178 0.0996 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0526 0.5272
Onchocerca volvulus Huntingtin homolog 0.0129 0.0698 0.4796
Loa Loa (eye worm) hypothetical protein 0.0031 0.0106 0.085
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0151 0.1486
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0128 0.4025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0151 0.1126
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.1668 1 0.5
Trypanosoma brucei unspecified product 0.0058 0.0272 0.8658
Onchocerca volvulus Alhambra homolog 0.0031 0.0106 0.0548
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.1081
Echinococcus multilocularis dna polymerase kappa 0.0065 0.0314 0.3131
Schistosoma mansoni hypothetical protein 0.0178 0.0996 1
Brugia malayi hypothetical protein 0.0019 0.0037 0.0205
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0019 0.0037 0.0205
Trichomonas vaginalis rotamase, putative 0.0034 0.0128 0.0883
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Brugia malayi hypothetical protein 0.0028 0.0088 0.0613
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0339
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0132 0.0979
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0151 0.1486
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0019 0.0037 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0151 0.1126
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0042 0.0243
Schistosoma mansoni hypothetical protein 0.0132 0.0719 0.719
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0092 0.0739
Brugia malayi conserved hypotetical protein 0.0018 0.0029 0.0137
Echinococcus multilocularis lamin 0.0028 0.0092 0.0892
Brugia malayi ecdysteroid receptor 0.0038 0.0151 0.1126
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.1668 1 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0106 0.1032
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0029 0.0261
Loa Loa (eye worm) hypothetical protein 0.0028 0.0092 0.0739
Brugia malayi hypothetical protein 0.0017 0.0024 0.0095
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0042 0.0392
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.0719 0.7216
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0128 0.4025
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0151 0.1486
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0151 0.1407
Brugia malayi bZIP transcription factor family protein 0.0081 0.0412 0.3251
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0032 0.0931
Schistosoma mansoni ap endonuclease 0.0021 0.005 0.0384
Schistosoma mansoni hypothetical protein 0.0031 0.0106 0.0949
Brugia malayi intermediate filament protein 0.0028 0.0092 0.0647
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0339
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0145 0.1352
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0151 0.0871
Echinococcus granulosus lamin dm0 0.0028 0.0092 0.0892
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0065 0.0314 0.2194
Brugia malayi hypothetical protein 0.0018 0.0029 0.0137
Brugia malayi hypothetical protein 0.002 0.0042 0.0243
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0272 0.8658
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0151 0.1126
Schistosoma mansoni DNA polymerase eta 0.0037 0.0145 0.1352
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0649
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0526 0.5272
Trichomonas vaginalis rotamase, putative 0.0035 0.0132 0.0918
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0019 0.0037 0.0256
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.008 0.0031
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0106 0.1032
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0144 0.1424
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0412 0.4116
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0151 0.1486
Brugia malayi steroid hormone receptor 0.0038 0.0151 0.1126
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0119 0.0865
Echinococcus granulosus geminin 0.0178 0.0996 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0151 0.1407
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0339
Onchocerca volvulus Huntingtin homolog 0.0129 0.0698 0.4796
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0151 0.1486
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0042 0.0339
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0339
Brugia malayi hypothetical protein 0.0073 0.0359 0.2824
Brugia malayi nuclear receptor NHR-88 0.0018 0.0029 0.0137
Brugia malayi hypothetical protein 0.0064 0.0306 0.2393
Schistosoma mansoni lamin 0.0028 0.0092 0.0808
Schistosoma mansoni nuclear receptor 0.0018 0.0029 0.0172
Loa Loa (eye worm) hypothetical protein 0.0129 0.0698 0.5623
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Brugia malayi PHD-finger family protein 0.0031 0.0106 0.076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0301
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.011 0.0994
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0029 0.0261
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0073 0.0703
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0151 0.1486
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.008 0.553
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0012 0.0091
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0314 1
Schistosoma mansoni hypothetical protein 0.0066 0.032 0.3126
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0106 0.7912
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0132 0.1067
Brugia malayi hypothetical protein 0.002 0.0042 0.0243
Loa Loa (eye worm) hypothetical protein 0.0048 0.021 0.1693
Schistosoma mansoni nuclear receptor 0.0018 0.0029 0.0172
Echinococcus granulosus intermediate filament protein 0.0028 0.0092 0.0892
Schistosoma mansoni thyroid hormone receptor 0.017 0.0949 0.9529
Schistosoma mansoni zinc finger protein 0.0018 0.0029 0.0172
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0159 0.5035
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0106 0.0949
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.1668 1 1
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0106 0.9488
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0151 0.1126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.021 0.1693
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.005 0.3053
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0314 1
Echinococcus granulosus dna polymerase eta 0.0037 0.0145 0.1431
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0151 0.1126
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Echinococcus multilocularis peregrin 0.0031 0.0106 0.1032
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0029 0.0261
Onchocerca volvulus 0.0038 0.0151 0.0871
Echinococcus multilocularis GPCR, family 2 0.0015 0.0012 0.0091
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0151 0.1407
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0106 0.7912
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.005 0.0338
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Loa Loa (eye worm) hypothetical protein 0.0039 0.0159 0.1281
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0151 0.1486
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0028 0.0088 0.0705
Brugia malayi Pre-SET motif family protein 0.0031 0.011 0.0796
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0301
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0029 0.0261
Onchocerca volvulus 0.0249 0.1424 1
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0151 0.1407
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0029 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0151 0.1213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0151 0.1213
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0128 0.6784
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.005 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0151 0.1213
Echinococcus multilocularis expressed protein 0.0035 0.0132 0.1303
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0301
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0041 0.0291
Echinococcus multilocularis lamin dm0 0.0028 0.0092 0.0892
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.0994
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.021 0.1611
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0151 0.1407
Brugia malayi tailless protein 0.0018 0.0029 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Echinococcus granulosus peregrin 0.0031 0.0106 0.1032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0314 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0359 0.3588
Entamoeba histolytica hypothetical protein 0.0073 0.0359 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.1241 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0073 0.0499
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.005 0.1539
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.005 0.1539
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0144 0.1345
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.005 0.0307
Schistosoma mansoni thyroid hormone receptor 0.017 0.0949 0.9529
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0359 0.3529
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0042 0.0304
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0092 0.0647
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0151 0.1126
Onchocerca volvulus 0.0064 0.0306 0.1987
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0029 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0151 0.1126
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0029 0.0172
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0042 0.0304
Plasmodium falciparum phd finger protein, putative 0.0031 0.0106 0.0056
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0359 0.3588
Schistosoma mansoni hypothetical protein 0.0178 0.0996 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0145 0.1431
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0955
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.0719 0.7216
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.1668 1 1
Giardia lamblia PHD finger protein 15 0.0031 0.0106 0.4057
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0151 0.1126
Brugia malayi nuclear hormone receptor 0.0038 0.0151 0.1126
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.008 0.0031
Trypanosoma brucei DNA polymerase eta, putative 0.0037 0.0145 0.4591
Trypanosoma brucei unspecified product 0.0026 0.0075 0.2357
Loa Loa (eye worm) RecQ helicase 0.0025 0.0073 0.0587
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0029 0.0172
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.008 0.6589
Echinococcus multilocularis jun protein 0.0081 0.0412 0.4116
Loa Loa (eye worm) DR-78 0.0018 0.0029 0.0234
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0128 0.4025
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0128 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0029 0.0261
Echinococcus multilocularis musashi 0.0028 0.0092 0.0892
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0151 0.1486
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Brugia malayi hypothetical protein 0.0129 0.0698 0.558
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0117 0.3699
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0178 0.1762
Brugia malayi hypothetical protein 0.0018 0.0029 0.0137
Onchocerca volvulus 0.0028 0.0092 0.0449
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0314 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.011 0.1076
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0029 0.0172
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.1213
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0019 0.0037 0.0301
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0151 0.0871
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0103 0.1006
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0314 0.0265
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0151 0.1407
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0029 0.0234
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0029 0.0172
Echinococcus multilocularis aryl hydrocarbon receptor 0.0028 0.0088 0.085
Entamoeba histolytica hypothetical protein 0.0073 0.0359 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0151 0.1126
Brugia malayi hypothetical protein 0.0019 0.0037 0.0205
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0029 0.0137
Plasmodium vivax SET domain protein, putative 0.0031 0.011 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0144 0.1164
Entamoeba histolytica hypothetical protein 0.0073 0.0359 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0151 0.1126
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0073 0.0499
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0019 0.0037 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0117 0.3699
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0151 0.1126
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0151 0.1486
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0029 0.0261
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0012 0.0098
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0092 0.0739
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0029 0.0137
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.011 0.1076
Echinococcus granulosus dna polymerase kappa 0.0065 0.0314 0.3131
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0098
Echinococcus granulosus aryl hydrocarbon receptor 0.0028 0.0088 0.085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0151 0.1486
Brugia malayi nuclear receptor NHR-88 0.0038 0.0151 0.1126
Schistosoma mansoni intermediate filament proteins 0.0028 0.0092 0.0808
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0151 0.1213
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0042 0.0392
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234
Brugia malayi polk-prov protein 0.0039 0.0159 0.1195
Onchocerca volvulus Protein cycle homolog 0.0019 0.0037 0.0059
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0303 0.2437
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0042 0.0243
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0029 0.0234
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0234

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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