Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Aminopeptidase B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aminopeptidase N | 0.0158 | 0.8898 | 0.7997 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0162 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0162 | 1 | 1 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0143 | 0.4498 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0158 | 0.886 | 0.7927 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0162 | 1 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0162 | 1 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0162 | 1 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0158 | 0.886 | 0.7927 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0162 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0158 | 0.886 | 0.886 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0143 | 0.4498 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0158 | 0.8898 | 0.7997 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0162 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0143 | 0.4498 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0162 | 1 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0162 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0162 | 1 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0162 | 1 | 1 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0143 | 0.4498 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0162 | 1 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0162 | 1 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0162 | 1 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0162 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0162 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0162 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0162 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0162 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0162 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0131 | 0.0693 | 0.0693 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0162 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12 ug ml-1 | Inhibition of rat liver aminopeptidase B using 0.2 mM L-leucine-beta-naphthylamide by colorimetry | ChEMBL. | 850237 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.