Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0197 | 0.1472 | 0.1041 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.034 | 0.3796 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0197 | 0.1472 | 0.3015 |
Giardia lamblia | Cathepsin B precursor | 0.0136 | 0.0481 | 0.5 |
Onchocerca volvulus | 0.0197 | 0.1472 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0197 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0136 | 0.0481 | 0.3269 |
Echinococcus granulosus | cathepsin b | 0.034 | 0.3796 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.0468 | 0.3182 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.034 | 0.3796 | 1 |
Plasmodium vivax | vivapain-2 | 0.0197 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0197 | 0.1472 | 1 |
Onchocerca volvulus | 0.0197 | 0.1472 | 1 | |
Onchocerca volvulus | 0.0197 | 0.1472 | 1 | |
Leishmania major | cysteine peptidase A (CPA) | 0.0197 | 0.1472 | 0.1041 |
Onchocerca volvulus | 0.0197 | 0.1472 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.3796 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0197 | 0.1472 | 0.3015 |
Onchocerca volvulus | Cathepsin F homolog | 0.0197 | 0.1472 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0197 | 0.1472 | 0.1472 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0136 | 0.0481 | 0.0481 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0724 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0724 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Leishmania major | cathepsin L-like protease | 0.0197 | 0.1472 | 0.1041 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0197 | 0.1472 | 0.3876 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0135 | 0.0468 | 0.1233 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0197 | 0.1472 | 0.3876 |
Echinococcus multilocularis | cysteine protease | 0.0197 | 0.1472 | 0.3876 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1472 | 0.3015 |
Echinococcus multilocularis | cysteine protease | 0.0197 | 0.1472 | 0.3876 |
Brugia malayi | Cathepsin L-like precursor | 0.0197 | 0.1472 | 0.3876 |
Leishmania major | cathepsin L-like protease | 0.0197 | 0.1472 | 0.1041 |
Plasmodium vivax | vivapain-2 | 0.0197 | 0.1472 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0724 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0197 | 0.1472 | 0.3876 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0197 | 0.1472 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0197 | 0.1472 | 0.3876 |
Leishmania major | cathepsin L-like protease | 0.0724 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0197 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0136 | 0.0481 | 0.1267 |
Onchocerca volvulus | 0.0197 | 0.1472 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0197 | 0.1472 | 0.1041 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0197 | 0.1472 | 0.3876 |
Echinococcus granulosus | cathepsin l1 | 0.0197 | 0.1472 | 0.3876 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0571 | 0.7525 | 0.7525 |
Onchocerca volvulus | 0.0197 | 0.1472 | 1 | |
Loa Loa (eye worm) | ctsf protein | 0.0197 | 0.1472 | 0.3015 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0136 | 0.0481 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0724 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.0468 | 0.1233 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0197 | 0.1472 | 0.3876 |
Onchocerca volvulus | Cathepsin L homolog | 0.0197 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0724 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0724 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0197 | 0.1472 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0662 | 0.8997 | 0.8997 |
Echinococcus multilocularis | cathepsin b | 0.034 | 0.3796 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0724 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0136 | 0.0481 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0136 | 0.0481 | 0.0481 |
Brugia malayi | Cathepsin L-like precursor | 0.0197 | 0.1472 | 0.3876 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0135 | 0.0468 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0724 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0197 | 0.1472 | 0.3876 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0197 | 0.1472 | 0.3015 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.0468 | 0.1233 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.034 | 0.3796 | 0.3796 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0197 | 0.1472 | 0.3876 |
Onchocerca volvulus | 0.0197 | 0.1472 | 1 | |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.034 | 0.3796 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0197 | 0.1472 | 0.3015 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0724 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0724 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0197 | 0.1472 | 0.3876 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.034 | 0.3796 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0197 | 0.1472 | 0.3876 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0197 | 0.1472 | 0.3876 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Echinococcus multilocularis | cathepsin b | 0.034 | 0.3796 | 1 |
Echinococcus granulosus | cathepsin b | 0.034 | 0.3796 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0724 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0724 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0135 | 0.0468 | 0.1233 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0724 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.034 | 0.3796 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0197 | 0.1472 | 0.3876 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0136 | 0.0481 | 0.0039 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0197 | 0.1472 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0197 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0724 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0724 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0724 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.0468 | 0.3182 |
Brugia malayi | cathepsin L-like precursor | 0.0135 | 0.0468 | 0.1233 |
Brugia malayi | Cathepsin L-like precursor | 0.0197 | 0.1472 | 0.3876 |
Toxoplasma gondii | cathepsin CPL | 0.0197 | 0.1472 | 1 |
Leishmania major | cathepsin L-like protease | 0.0197 | 0.1472 | 0.1041 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0135 | 0.0468 | 0.1233 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0197 | 0.1472 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.