Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.5303 | 0.4837 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.5303 | 0.5802 |
Brugia malayi | hypothetical protein | 0.0027 | 0.266 | 0.266 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.4524 | 0.4775 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0901 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0048 | 0.8487 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0901 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0048 | 0.8487 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.0901 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.266 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0048 | 0.8487 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0048 | 0.8487 | 0.8487 |
Leishmania major | DNA polymerase eta, putative | 0.0048 | 0.8487 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0048 | 0.8487 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0048 | 0.8487 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.8487 | 0.8338 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.0901 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.0901 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.0901 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.266 | 0.2319 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.5303 | 0.5303 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.266 | 0.2319 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.266 | 0.2319 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.4524 | 0.4775 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0901 | 0.0901 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.266 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.266 | 0.1934 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.266 | 0.2319 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.0901 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.266 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.0901 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0034 | 0.4524 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimalarial activity against Plasmodium berghei infected in mouse assessed as increase of survival time of host | ChEMBL. | 376849 | |
Activity (functional) | Antimalarial activity against Plasmodium berghei infected in mouse assessed as increase of survival time of host at 640 mg/kg | ChEMBL. | 376849 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.