TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 482.492 | Formula: C22H26N8O5
H donors: 4 H acceptors: 8 LogP: 0.23 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)CC[C@@H](C(=O)O)NC(=O)c1ccc(cc1)N(Cc1cnc2c(n1)c(N)nc(n2)N)C
InChi: 1S/C22H26N8O5/c1-3-35-16(31)9-8-15(21(33)34)27-20(32)12-4-6-14(7-5-12)30(2)11-13-10-25-19-17(26-13)18(23)28-22(24)29-19/h4-7,10,15H,3,8-9,11H2,1-2H3,(H,27,32)(H,33,34)(H4,23,24,25,28,29)/t15-/m0/s1
InChiKey: CYBKLZCFMQQPOM-HNNXBMFYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	amine GPCR	0.0025	0.0341	0.0433
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0341	0.0433
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0025	0.0341	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Onchocerca volvulus		0.0025	0.0341	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0341	0.0472
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0341	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Onchocerca volvulus		0.0025	0.0341	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0341	0.0472
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0341	0.0433
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0341	0.0433
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0341	0.0472
Onchocerca volvulus		0.0025	0.0341	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus granulosus	serotonin receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	serotonin receptor	0.0025	0.0341	0.0472
Schistosoma mansoni	hypothetical protein	0.0025	0.0341	0.0433
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0341	0.0472
Onchocerca volvulus		0.0025	0.0341	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0341	0.0433
Echinococcus granulosus	sex peptide receptor	0.0025	0.0341	0.0472
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0025	0.0341	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0341	0.0472
Onchocerca volvulus		0.0025	0.0341	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0341	0.0472
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0341	0.0167
Loa Loa (eye worm)	TYRA-2 protein	0.0025	0.0341	0.0167
Onchocerca volvulus		0.0025	0.0341	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0025	0.0341	0.0472
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3818	0.4014
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0068	0.724	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	sex peptide receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Onchocerca volvulus		0.0025	0.0341	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.4163	0.4395
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0341	0.0472
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0535	0.0739
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0341	0.0433
Schistosoma mansoni	neuropeptide f receptor 76f	0.0025	0.0341	0.0433
Schistosoma mansoni	hypothetical protein	0.0025	0.0341	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1784	0.1763
Echinococcus granulosus	7TM GPCR rhodopsin	0.0025	0.0341	0.0472
Schistosoma mansoni	hypothetical protein	0.0034	0.1784	0.2262
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0025	0.0341	0.0433
Loa Loa (eye worm)	melatonin receptor type 1A	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus granulosus	g-protein coupled receptor	0.0025	0.0341	0.0472
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0025	0.0341	0.0167
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus granulosus	neuropeptide receptor A26	0.0025	0.0341	0.0472
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.2959	0.4088
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0341	0.0472
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0341	0.0433
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0041	0.2951	0.4076
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0025	0.0341	0.0472
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0025	0.0341	0.0472
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0341	0.0472
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0341	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.4244	0.4485
Echinococcus multilocularis	allatostatin A receptor	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Brugia malayi	hypothetical protein	0.0041	0.2959	0.271
Loa Loa (eye worm)	hypothetical protein	0.0049	0.4244	0.4485
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0025	0.0341	0.0167
Onchocerca volvulus		0.0025	0.0341	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0025	0.0341	0.0433
Schistosoma mansoni	adenoreceptor	0.0025	0.0341	0.0433
Schistosoma mansoni	bromodomain containing protein	0.0072	0.7886	1
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Onchocerca volvulus		0.0025	0.0341	0.5
Entamoeba histolytica	hypothetical protein	0.0041	0.2959	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0025	0.0341	0.0433
Schistosoma mansoni	amine GPCR	0.0025	0.0341	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0025	0.0341	0.0433
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0341	0.0433
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0341	0.0433
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0341	0.0472
Onchocerca volvulus		0.0025	0.0341	0.5
Onchocerca volvulus		0.0025	0.0341	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0025	0.0341	0.0472
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0025	0.0341	0.0433
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.2959	0.3753
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0041	0.2951	0.4076
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0025	0.0341	0.0472
Schistosoma mansoni	histamine h1 receptor	0.0025	0.0341	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0025	0.0341	0.0472
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0025	0.0341	0.0433
Echinococcus multilocularis	serotonin receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	somatostatin receptor	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Schistosoma mansoni	opsin-like receptor	0.0025	0.0341	0.0433
Echinococcus multilocularis	dro:myosuppressin receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	orexin receptor type 2	0.0025	0.0341	0.0472
Echinococcus multilocularis	g-protein coupled receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0341	0.0433
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0341	0.0472
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0341	0.0472
Entamoeba histolytica	hypothetical protein	0.0041	0.2959	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus granulosus	dro:myosuppressin receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	allatostatin A receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0081	0.9228	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	hypothetical protein	0.0025	0.0341	0.0472
Onchocerca volvulus		0.0025	0.0341	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0341	0.0433
Brugia malayi	PHD-finger family protein	0.0028	0.0963	0.0643
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0341	0.0433
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Schistosoma mansoni	opsin-like receptor	0.0025	0.0341	0.0433
Echinococcus multilocularis	neuropeptide s receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	G protein coupled receptor 139	0.0025	0.0341	0.0472
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0341	0.0433
Echinococcus multilocularis	somatostatin receptor	0.0025	0.0341	0.0472
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0341	0.0433
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	neuropeptide s receptor	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus granulosus	7tm_1 domain containing protein	0.0025	0.0341	0.0472
Echinococcus multilocularis	G protein coupled receptor 139	0.0025	0.0341	0.0472
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Onchocerca volvulus		0.0025	0.0341	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0025	0.0341	0.0167
Entamoeba histolytica	hypothetical protein	0.0041	0.2959	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.4244	0.4041
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Schistosoma mansoni	opsin-like receptor	0.0025	0.0341	0.0433
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0044	0.3391	0.3541
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0341	0.0472
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0025	0.0341	0.0472
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0535	0.0739
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0025	0.0341	0.0472
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0341	0.0433
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	neuropeptide receptor A26	0.0025	0.0341	0.0472
Schistosoma mansoni	hypothetical protein	0.0025	0.0341	0.0433
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0341	0.0433
Entamoeba histolytica	hypothetical protein	0.0041	0.2959	0.5
Schistosoma mansoni	amine GPCR	0.0025	0.0341	0.0433
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0341	0.0433
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0341	0.0433
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0341	0.0433
Schistosoma mansoni	hypothetical protein	0.0025	0.0341	0.0433
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0341	0.0433
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0025	0.0341	0.0472
Schistosoma mansoni	growth hormone secretagogue receptor	0.0025	0.0341	0.0433
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0068	0.724	1
Onchocerca volvulus		0.0025	0.0341	0.5
Onchocerca volvulus		0.0025	0.0341	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0341	0.0433
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0025	0.0341	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0341	0.0472
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0535	0.0679
Brugia malayi	Bromodomain containing protein	0.0044	0.3378	0.3144
Schistosoma mansoni	hypothetical protein	0.0041	0.2959	0.3753
Echinococcus granulosus	fmrfamide receptor	0.0025	0.0341	0.0472
Schistosoma mansoni	amine GPCR	0.0025	0.0341	0.0433
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.1784	0.1493
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0025	0.0341	0.0472
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0025	0.0341	0.0472
Schistosoma mansoni	hypothetical protein	0.0024	0.0191	0.0242
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.4244	0.4041
Echinococcus multilocularis	orexin receptor type 2	0.0025	0.0341	0.0472
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0341	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0341	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0341	0.0167
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0025	0.0341	0.0472
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.2959	0.4088
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0341	0.0433
Schistosoma mansoni	myosin xvIII	0.0025	0.0341	0.0433
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0025	0.0341	0.0433
Onchocerca volvulus		0.0025	0.0341	0.5
Onchocerca volvulus		0.0025	0.0341	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0341	0.0472
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0341	0.0167
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0025	0.0341	0.0433
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0341	0.0433
Schistosoma mansoni	amine GPCR	0.0025	0.0341	0.0433
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0025	0.0341	0.0433

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	= 0.58 10'-6 mol/L	Growth inhibition of human CCRF-CEM cells	ChEMBL.	565818

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3245813

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1897226