Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.3559 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Brugia malayi | Trypsin family protein | 0.0238 | 0.3382 | 0.9503 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.3559 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.3559 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.3559 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.3559 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0093 | 0 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0238 | 0.3382 | 0.3382 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0238 | 0.3382 | 0.3382 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3382 | 0.9503 |
Onchocerca volvulus | 0.0208 | 0.2671 | 0.7897 | |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.3559 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.3559 | 0.3559 |
Toxoplasma gondii | kringle domain-containing protein | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.3559 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3382 | 0.9503 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.3559 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | 0.0238 | 0.3382 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.