Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | 0.0208 | 0.2671 | 0.7897 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.3559 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0093 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0238 | 0.3382 | 0.3382 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.3559 | 0.3559 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.3559 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.3559 | 1 |
Onchocerca volvulus | 0.0238 | 0.3382 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.3559 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3382 | 0.9503 |
Brugia malayi | Trypsin family protein | 0.0238 | 0.3382 | 0.9503 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.3559 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.3559 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.3559 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.3559 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0238 | 0.3382 | 0.3382 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3382 | 0.9503 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.