Detailed information for compound 1898974

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 333.234 | Formula: C11H16N3O7P
  • H donors: 3 H acceptors: 4 LogP: -2.47 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cn(c(=O)nc1N)[C@@H]1O[C@H]2[C@H]([C@H]1O)OP(=O)(OC2)O
  • InChi: 1S/C11H16N3O7P/c1-2-5-3-14(11(16)13-9(5)12)10-7(15)8-6(20-10)4-19-22(17,18)21-8/h3,6-8,10,15H,2,4H2,1H3,(H,17,18)(H2,12,13,16)/t6-,7-,8-,10-/m1/s1
  • InChiKey: RNPKQCPIOIDKEX-FDDDBJFASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii exonuclease III APE 0.0019 0.0029 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0098 0.0333
Schistosoma mansoni inositol monophosphatase 0.0077 0.0247 0.0246
Schistosoma mansoni ap endonuclease 0.0019 0.0029 0.0028
Echinococcus multilocularis General substrate transporter 0.0088 0.0289 0.0289
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.1119 0.1118
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.015 0.0533
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0703 0.26 1
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0027 0.0026
Mycobacterium ulcerans beta-lactamase 0.0037 0.0098 0.0473
Echinococcus granulosus glutamate NMDA receptor subunit 0.0061 0.0188 0.0188
Chlamydia trachomatis dihydrofolate reductase 0.0327 0.1187 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Leishmania major glucose transporter, lmgt1 0.0032 0.0078 0.0253
Brugia malayi Carboxylesterase family protein 0.0452 0.1655 0.1654
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0078 0.0253
Schistosoma mansoni ap endonuclease 0.0019 0.0029 0.0028
Leishmania major N-myristoyl transferase, putative 0.0535 0.1968 0.7559
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0012 0.0012
Echinococcus granulosus acetylcholinesterase 0.2673 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0099 0.0098
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0068 0.0214 0.0213
Trypanosoma brucei glucose transporter 2A 0.0032 0.0078 0.0253
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0452 0.1655 0.9012
Echinococcus granulosus inositol monophosphatase 1 0.0077 0.0247 0.0247
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0055 0.0055
Toxoplasma gondii ABC1 family protein 0.0037 0.0098 0.0333
Echinococcus granulosus dnaJ subfamily B 0.0402 0.1467 0.1467
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0077 0.0247 0.1124
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0012 0.0012
Schistosoma mansoni sugar transporter 0.0014 0.0012 0.0012
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0098 0.0098
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0029 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0452 0.1655 0.8396
Brugia malayi Carboxylesterase family protein 0.0452 0.1655 0.1654
Echinococcus multilocularis acetylcholinesterase 0.2673 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.015 0.0533
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0188 0.0188
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0053 0.0201
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0078 0.0253
Giardia lamblia CDC72 0.0535 0.1968 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0046 0.0173
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0038 0.0143
Mycobacterium ulcerans hypothetical protein 0.0037 0.0098 0.0473
Brugia malayi hypothetical protein 0.0452 0.1655 0.1654
Brugia malayi jmjC domain containing protein 0.0038 0.0099 0.0099
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0077 0.0076
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0053 0.0201
Echinococcus granulosus neuroligin 0.0452 0.1655 0.1655
Schistosoma mansoni glucose transport protein 0.0103 0.0344 0.0343
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0029 0.0108
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0344 0.0344
Trypanosoma cruzi N-myristoyl transferase, putative 0.0535 0.1968 0.7559
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0038 0.0038
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0067 0.0067
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0452 0.1655 0.1654
Brugia malayi Importin beta-1 subunit 0.0029 0.0067 0.0066
Trypanosoma brucei glucose transporter, putative 0.0032 0.0078 0.0253
Brugia malayi hypothetical protein 0.0014 0.0012 0.0012
Echinococcus granulosus solute carrier family 22 0.0014 0.0012 0.0012
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0078 0.0253
Trypanosoma cruzi hexose transporter 0.0032 0.0078 0.0253
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.1467 0.1467
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0029 0.0085
Loa Loa (eye worm) carboxylesterase 0.0452 0.1655 0.1654
Loa Loa (eye worm) hypothetical protein 0.0452 0.1655 0.1654
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0327 0.1187 0.6445
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0077 0.0076
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.0037 0.0098 0.0473
Plasmodium falciparum phd finger protein, putative 0.003 0.0069 0.0264
Echinococcus multilocularis dihydrofolate reductase 0.0327 0.1187 0.1187
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0029 0.0029
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0098 0.0473
Echinococcus granulosus acetylcholinesterase 0.2673 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0029 0.0064
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0098 0.0098
Echinococcus multilocularis thymidylate synthase 0.0499 0.1835 0.1835
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0077 0.0247 0.1287
Loa Loa (eye worm) thymidylate synthase 0.0499 0.1835 0.1834
Onchocerca volvulus 0.0037 0.0098 0.0473
Echinococcus granulosus solute carrier family 22 0.0014 0.0012 0.0012
Brugia malayi dihydrofolate reductase family protein 0.0327 0.1187 0.1186
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0078 0.0334
Brugia malayi CXXC zinc finger family protein 0.0028 0.0064 0.0064
Brugia malayi hypothetical protein 0.0238 0.0851 0.085
Schistosoma mansoni hypothetical protein 0.0402 0.1467 0.1467
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Loa Loa (eye worm) inositol-1 0.0077 0.0247 0.0246
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.015 0.015
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0012 0.0012
Brugia malayi beta-lactamase family protein 0.0037 0.0098 0.0098
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0182 0.0181
Trichomonas vaginalis spcc417.12 protein, putative 0.0452 0.1655 0.8396
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0029 0.0064
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0247 0.0907
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0093 0.0093
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0078 0.0253
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0061 0.0188 0.0188
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0029 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0183 0.0182
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0452 0.1655 0.1654
Schistosoma mansoni importin beta-1 0.0029 0.0067 0.0066
Echinococcus multilocularis snurportin 1 0.0309 0.1119 0.1119
Brugia malayi Dihydrofolate reductase 0.0327 0.1187 0.1186
Mycobacterium ulcerans ion transport protein 0.0152 0.0531 0.2846
Trypanosoma brucei glucose transporter, putative 0.0032 0.0078 0.0253
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0214 0.0214
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0247 0.0907
Schistosoma mansoni hypothetical protein 0.0032 0.0077 0.0076
Brugia malayi hypothetical protein 0.0014 0.0012 0.0012
Loa Loa (eye worm) N-myristoyltransferase 2 0.0535 0.1968 0.1968
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0098 0.044
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0069 0.0217 0.0681
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0012 0.0012
Trypanosoma brucei N-myristoyl transferase, putative 0.0535 0.1968 0.7559
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2673 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0214 0.0214
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.015 0.0705
Loa Loa (eye worm) hypothetical protein 0.0452 0.1655 0.1654
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.015 0.0533
Brugia malayi PHD-finger family protein 0.003 0.0069 0.0069
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0021 0.002
Schistosoma mansoni cpg binding protein 0.003 0.007 0.0069
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0703 0.26 1
Brugia malayi Carboxylesterase family protein 0.0452 0.1655 0.1654
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.015 0.015
Echinococcus granulosus carboxylesterase 5A 0.2673 1 1
Onchocerca volvulus 0.0037 0.0098 0.0473
Schistosoma mansoni neuroligin 3 (S09 family) 0.0452 0.1655 0.1654
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0248 0.0248
Brugia malayi MAP kinase sur-1 0.0051 0.015 0.015
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.015 0.0533
Schistosoma mansoni sugar transporter 0.0014 0.0012 0.0012
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0182 0.0932
Schistosoma mansoni glutamate receptor NMDA 0.0061 0.0188 0.0188
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0159 0.0566
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0078 0.0334
Echinococcus granulosus dihydrofolate reductase 0.0327 0.1187 0.1187
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Echinococcus granulosus solute carrier family 22 0.0014 0.0012 0.0012
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0067 0.0211
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0333 0.0332
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0182 0.0932
Loa Loa (eye worm) carboxylesterase 0.2673 1 1
Loa Loa (eye worm) hypothetical protein 0.0452 0.1655 0.1654
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0182 0.0181
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0182 0.0932
Entamoeba histolytica Ran family GTPase 0.0021 0.0038 0.0047
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.021 0.0745 0.0745
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0098 0.0473
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0098 0.0333
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Onchocerca volvulus 0.0499 0.1835 1
Schistosoma mansoni hypothetical protein 0.0103 0.0344 0.0343
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0535 0.1968 0.757
Trypanosoma brucei glucose transporter, putative 0.0032 0.0078 0.0253
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0053 0.0158
Onchocerca volvulus 0.0452 0.1655 0.9012
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0055 0.0055
Echinococcus multilocularis para nitrobenzyl esterase 0.0452 0.1655 0.1655
Loa Loa (eye worm) hypothetical protein 0.0452 0.1655 0.1654
Leishmania major glucose transporter, lmgt2 0.0032 0.0078 0.0253
Loa Loa (eye worm) carboxylesterase 0.0452 0.1655 0.1654
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0077 0.0076
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0344 0.0344
Plasmodium falciparum hexose transporter 0.0103 0.0344 0.1319
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0069
Brugia malayi N-myristoyltransferase 2 0.0535 0.1968 0.1968
Echinococcus multilocularis solute carrier family 22 0.0014 0.0012 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0098 0.0333
Loa Loa (eye worm) voltage-gated potassium channel 0.0203 0.0721 0.0721
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0182 0.0656
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0069 0.0069
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0001 0.0001
Brugia malayi Sugar transporter family protein 0.0014 0.0012 0.0012
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0323 0.0323
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0029 0.0064
Onchocerca volvulus 0.0452 0.1655 0.9012
Schistosoma mansoni hypothetical protein 0.0032 0.0077 0.0076
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0029 0.0029
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0452 0.1655 0.1655
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0098 0.0098
Echinococcus multilocularis GPCR, family 2 0.0032 0.0077 0.0077
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0069 0.0221
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.015 0.015
Schistosoma mansoni hypothetical protein 0.0032 0.0077 0.0076
Trypanosoma cruzi N-myristoyl transferase, putative 0.0535 0.1968 0.7559
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0028 0.0086
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.015 0.015
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.0344 0.0344
Brugia malayi thymidylate synthase 0.0499 0.1835 0.1834
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0182 0.0182
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0078 0.0334
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0333 0.0332
Onchocerca volvulus Alhambra homolog 0.003 0.0069 0.0314
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.021 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.0051 0.0149 0.0149
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0078 0.0334
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0098 0.0375
Brugia malayi RNA, U transporter 1 0.0082 0.0267 0.0267
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0029 0.0092
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0012 0.0044
Trichomonas vaginalis esterase, putative 0.0037 0.0098 0.044
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0067 0.0211
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0113 0.0113
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0344 0.0344
Brugia malayi beta-lactamase 0.0037 0.0098 0.0098
Echinococcus multilocularis carboxylesterase 5A 0.2673 1 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0098 0.0473
Plasmodium vivax importin-beta 2, putative 0.0029 0.0067 0.0253
Trichomonas vaginalis N-myristoyl transferase, putative 0.0535 0.1968 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0333 0.0332
Trypanosoma brucei N-myristoyltransferase 0.0535 0.1968 0.7559
Brugia malayi hypothetical protein 0.0014 0.0012 0.0012
Loa Loa (eye worm) sugar transporter 0.0103 0.0344 0.0343
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.021 0.0745 0.0745
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0535 0.1968 0.757
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.015 0.0533
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0077 0.0077
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0098 0.0473
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0098 0.0473
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0078 0.0253
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0053 0.0158
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.015 0.015
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0099 0.0099
Echinococcus multilocularis inositol monophosphatase 1 0.0077 0.0247 0.0247
Brugia malayi Sugar transporter family protein 0.0014 0.0012 0.0012
Echinococcus multilocularis neuroligin 0.0452 0.1655 0.1655
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0028 0.0086
Echinococcus multilocularis BC026374 protein (S09 family) 0.0452 0.1655 0.1655
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0038
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0703 0.26 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0098 0.0473
Leishmania major importin beta-1 subunit, putative 0.0023 0.0046 0.0131
Schistosoma mansoni gliotactin 0.0452 0.1655 0.1654
Plasmodium vivax hypothetical protein, conserved 0.003 0.0069 0.0264
Schistosoma mansoni sugar transporter 0.0014 0.0012 0.0012
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0038 0.01
Leishmania major GTP-binding protein, putative 0.0021 0.0038 0.01
Loa Loa (eye worm) sugar transporter 0.0014 0.0012 0.0012
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.2673 1 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0452 0.1655 0.9012
Leishmania major hypothetical protein, conserved 0.0037 0.0098 0.0333
Loa Loa (eye worm) dihydrofolate reductase 0.0327 0.1187 0.1186
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0099 0.0099
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.021 0.0745 0.0745
Schistosoma mansoni N-myristoyltransferase 0.0535 0.1968 0.1968
Schistosoma mansoni glucose transport protein 0.0103 0.0344 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0078 0.0334
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0703 0.26 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.015 0.0705
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0452 0.1655 0.1654
Plasmodium falciparum importin beta, putative 0.0029 0.0067 0.0253
Echinococcus granulosus thymidylate synthase 0.0499 0.1835 0.1835
Schistosoma mansoni cpg binding protein 0.003 0.007 0.0069
Trypanosoma brucei glucose transporter, putative 0.0032 0.0078 0.0253
Echinococcus multilocularis solute carrier family 22 0.0014 0.0012 0.0012
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0053 0.0158
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0029 0.0085
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0535 0.1968 0.1968
Brugia malayi hypothetical protein 0.0016 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0023 0.0046 0.0089
Loa Loa (eye worm) hypothetical protein 0.0037 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0032 0.0077 0.0076
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0012 0.0012
Trichomonas vaginalis inositol monophosphatase, putative 0.0077 0.0247 0.1199
Loa Loa (eye worm) hypothetical protein 0.0037 0.0098 0.0098
Onchocerca volvulus 0.0028 0.0064 0.0284
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0069 0.0221
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0098 0.044
Schistosoma mansoni inositol monophosphatase 0.0077 0.0247 0.0246
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0077 0.0247 1
Schistosoma mansoni cpg binding protein 0.0028 0.0064 0.0063
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0327 0.1187 0.6269
Brugia malayi hypothetical protein 0.0025 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.2673 1 1
Giardia lamblia PHD finger protein 15 0.003 0.0069 0.0293
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0113 0.0113
Echinococcus granulosus GPCR family 2 0.0032 0.0077 0.0077
Echinococcus granulosus peregrin 0.003 0.0069 0.0069
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.015 0.0533
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Schistosoma mansoni glucose transporter 0.0014 0.0012 0.0012
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0247 0.0907
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0077 0.0077
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.015 0.0533
Onchocerca volvulus 0.0037 0.0098 0.0473
Mycobacterium ulcerans carboxylesterase, LipT 0.0452 0.1655 0.9012
Echinococcus granulosus BC026374 protein S09 family 0.0452 0.1655 0.1655
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0132
Trichomonas vaginalis ran, putative 0.0021 0.0038 0.0132
Echinococcus granulosus snurportin 1 0.0309 0.1119 0.1119
Loa Loa (eye worm) hypothetical protein 0.0452 0.1655 0.1654
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0098 0.0098
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0029 0.0711
Mycobacterium ulcerans lipase LipD 0.0037 0.0098 0.0473
Trypanosoma brucei glucose transporter 1E 0.0032 0.0078 0.0253
Plasmodium vivax sugar transporter, putative 0.0014 0.0012 0.0044
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0078 0.0253
Brugia malayi Carboxylesterase family protein 0.2673 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0452 0.1655 0.1654
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0452 0.1655 0.1655
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0076
Echinococcus multilocularis solute carrier family 22 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Brugia malayi Sugar transporter family protein 0.0103 0.0344 0.0343
Schistosoma mansoni acetylcholinesterase 0.0452 0.1655 0.1654
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0182 0.0182
Onchocerca volvulus 0.0452 0.1655 0.9012
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0098 0.0473
Mycobacterium tuberculosis Hypothetical protein 0.0238 0.0851 0.4601
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0029 0.0064
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0344 0.0344
Echinococcus granulosus importin subunit beta 1 0.0029 0.0067 0.0067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.0855 0.4623
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0098 0.044
Echinococcus granulosus General substrate transporter 0.0088 0.0289 0.0289
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0098 0.0098
Schistosoma mansoni sugar transporter 0.0014 0.0012 0.0012
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0344 0.0344
Schistosoma mansoni dihydrofolate reductase 0.0327 0.1187 0.1186
Schistosoma mansoni ran 0.0021 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Trypanosoma brucei glucose transporter, putative 0.0032 0.0078 0.0253
Brugia malayi beta-lactamase family protein 0.0037 0.0098 0.0098
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0053 0.0158
Leishmania major glucose transporter, lmgt3 0.0032 0.0078 0.0253
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0078 0.0253
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0182 0.0656
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.015 0.0705
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0038 0.0038
Trypanosoma brucei protein kinase, putative 0.0051 0.015 0.0533
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0535 0.1968 0.1968
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.015 0.0533
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0535 0.1968 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0012 0.0012
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0238 0.0851 0.4287
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0098 0.0473
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0067 0.0211
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0069 0.0069
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0247 0.1199
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0046 0.0173
Mycobacterium tuberculosis Conserved protein 0.0037 0.0098 0.0473
Schistosoma mansoni BC026374 protein (S09 family) 0.0452 0.1655 0.1654
Schistosoma mansoni ran 0.0021 0.0038 0.0037
Brugia malayi major facilitator superfamily protein 0.0014 0.0012 0.0012
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0098 0.0098
Trichomonas vaginalis N-myristoyl transferase, putative 0.0352 0.1279 0.6475
Mycobacterium ulcerans thymidylate synthase 0.0499 0.1835 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0012 0.0012
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0703 0.26 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0182 0.0932
Trypanosoma brucei glucose transporter, putative 0.0032 0.0078 0.0253
Trypanosoma brucei glucose transporter, putative 0.0032 0.0078 0.0253
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0238 0.0851 0.3241
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0038
Brugia malayi Carboxylesterase family protein 0.0452 0.1655 0.1654
Onchocerca volvulus 0.0452 0.1655 0.9012
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0077 0.0247 0.0907
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0098 0.044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0077 0.0077
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0099 0.0098
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0703 0.26 1
Loa Loa (eye worm) acetylcholinesterase 1 0.2673 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.015 0.0705
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0499 0.1835 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0069 0.0217 0.1121
Echinococcus multilocularis acetylcholinesterase 0.2673 1 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0029 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0098 0.044
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.003 0.0069 0.0069
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0046 0.0173
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0078 0.0334
Echinococcus granulosus para nitrobenzyl esterase 0.0452 0.1655 0.1655
Brugia malayi Inositol-1 0.0077 0.0247 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0344 0.1694
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0001 0.0001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0038 0.01
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0098 0.0098
Echinococcus multilocularis peregrin 0.003 0.0069 0.0069
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.0344 0.1281
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0247 0.1199
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.015 0.0705
Brugia malayi jmjC domain containing protein 0.0097 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0098 0.0473
Loa Loa (eye worm) hypothetical protein 0.01 0.0333 0.0332
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0029 0.0085
Loa Loa (eye worm) hypothetical protein 0.0452 0.1655 0.1654
Loa Loa (eye worm) hypothetical protein 0.0037 0.0098 0.0098
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0069 0.0069
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0452 0.1655 0.9012
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0327 0.1187 0.6445
Leishmania major hypothetical protein, conserved 0.0025 0.0053 0.0158
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0078 0.0334
Schistosoma mansoni hypothetical protein 0.0309 0.1119 0.1118
Loa Loa (eye worm) beta-lactamase 0.0037 0.0098 0.0098
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0053 0.0201
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0038 0.01
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0069 0.0069
Plasmodium vivax hexose transporter 0.0103 0.0344 0.1319
Onchocerca volvulus 0.0452 0.1655 0.9012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0098 0.0098
Schistosoma mansoni glucose transport protein 0.0103 0.0344 0.0343
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0029 0.0028
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0064 0.0064
Brugia malayi major facilitator superfamily protein 0.0014 0.0012 0.0012
Brugia malayi Bromodomain containing protein 0.003 0.0069 0.0069
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0344 0.0344
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0499 0.1835 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0098 0.0098
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0046 0.0131
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0038 0.01
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0247 0.0907
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.015 0.015
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0499 0.1835 0.1834
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0098 0.0473
Echinococcus multilocularis cpg binding protein 0.003 0.007 0.007
Trypanosoma brucei glucose transporter, putative 0.0032 0.0078 0.0253
Echinococcus granulosus cpg binding protein 0.003 0.007 0.007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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