Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | No references | |
Electrophorus electricus | Acetylcholinesterase | No references | |
Homo sapiens | acetylcholinesterase (Yt blood group) | No references | |
Homo sapiens | beta-site APP-cleaving enzyme 1 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | 0.0238 | 0.3382 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.3559 | 0.3559 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3382 | 0.9503 |
Onchocerca volvulus | 0.0208 | 0.2671 | 0.7897 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.3559 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.3559 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.3559 | 1 |
Brugia malayi | Trypsin family protein | 0.0238 | 0.3382 | 0.9503 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0093 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0093 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.3559 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.3559 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3382 | 0.9503 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.3559 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0238 | 0.3382 | 0.3382 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.3559 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0238 | 0.3382 | 0.3382 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.3559 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.4 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 9.4 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 80 nM | ß-Secretase (BACE-1) | BINDINGDB. | No reference |
IC50 (binding) | = 80 nM | ß-Secretase (BACE-1) | BINDINGDB. | No reference |
IC50 (binding) | = 98.9 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 265 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 513 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 2930 nM | Inhibition Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.