Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0538 | 0.0538 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0538 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0538 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.1898 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0073 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.1898 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0538 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0538 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.0538 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.1898 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0538 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1898 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0538 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0538 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.1898 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1898 | 0.1437 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1898 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.1898 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.1898 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.1898 | 0.1898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.