Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0202 | 0.291 | 0.2874 |
Schistosoma mansoni | ran | 0.0021 | 0.0104 | 0.0065 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 0.291 | 0.3453 |
Echinococcus granulosus | Smad4 | 0.0045 | 0.0471 | 0.0508 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.002 | 0.0085 | 0.0035 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0102 | 0.5 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0222 | 0.0208 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0102 | 0.4571 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0045 | 0.0471 | 0.0508 |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.002 | 0.0085 | 0.0042 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0102 | 0.0052 |
Loa Loa (eye worm) | TAR-binding protein | 0.0202 | 0.291 | 0.2874 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 0.1364 | 0.1586 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 0.291 | 0.3453 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0102 | 0.4571 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0102 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0222 | 0.0173 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0159 | 0.011 |
Schistosoma mansoni | smad | 0.002 | 0.0085 | 0.0042 |
Schistosoma mansoni | Smad4 | 0.0045 | 0.0471 | 0.0508 |
Echinococcus multilocularis | snurportin 1 | 0.0308 | 0.4561 | 0.5446 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0045 | 0.0471 | 0.0422 |
Echinococcus multilocularis | Smad4 | 0.0045 | 0.0471 | 0.0508 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0102 | 0.4571 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0202 | 0.291 | 0.2874 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0102 | 0.4571 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0102 | 0.4571 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.0102 | 0.0062 |
Schistosoma mansoni | smad1 5 8 and | 0.0045 | 0.0471 | 0.0508 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.0102 | 0.5 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0138 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0362 | 0.5389 | 0.5366 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.5389 | 0.5366 |
Echinococcus multilocularis | geminin | 0.0551 | 0.8333 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0551 | 0.8333 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0308 | 0.4561 | 0.5446 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.002 | 0.0085 | 0.0035 |
Loa Loa (eye worm) | nuclear factor I | 0.0025 | 0.0159 | 0.011 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0102 | 0.1364 | 0.1586 |
Schistosoma mansoni | Smad4 | 0.002 | 0.0085 | 0.0042 |
Onchocerca volvulus | Mothers against decapentaplegic homolog | 0.002 | 0.0085 | 0.0066 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0104 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0045 | 0.0471 | 0.0422 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0803 | 0.0909 |
Schistosoma mansoni | smad1 5 8 and | 0.0045 | 0.0471 | 0.0508 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0222 | 0.0208 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0803 | 0.0909 |
Echinococcus granulosus | smad | 0.0045 | 0.0471 | 0.0508 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0066 | 0.0803 | 0.0756 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0045 | 0.0471 | 0.0508 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0104 | 0.4678 |
Brugia malayi | RNA binding protein | 0.0202 | 0.291 | 0.2874 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 0.291 | 0.3453 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0102 | 0.1364 | 0.1586 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 0.291 | 0.3453 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.002 | 0.0085 | 0.0035 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0045 | 0.0471 | 0.0508 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0102 | 0.0062 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0102 | 0.4571 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.3026 | 0.2991 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0308 | 0.4561 | 0.4534 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.002 | 0.0085 | 0.0042 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.021 | 0.3026 | 0.2991 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.0102 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0045 | 0.0471 | 0.0508 |
Schistosoma mansoni | smad | 0.0045 | 0.0471 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1997 | 0.1957 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0222 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 0.291 | 0.3453 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0222 | 1 |
Echinococcus granulosus | geminin | 0.0551 | 0.8333 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.002 | 0.0085 | 0.0042 |
Schistosoma mansoni | hypothetical protein | 0.0308 | 0.4561 | 0.5446 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0102 | 0.1364 | 0.1586 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0803 | 0.0909 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0102 | 0.4571 |
Schistosoma mansoni | hypothetical protein | 0.0551 | 0.8333 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0066 | 0.0803 | 0.0909 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0803 | 0.0909 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0102 | 0.1364 | 0.1586 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0102 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0085 | 0.0035 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0104 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0159 | 0.011 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0102 | 0.4571 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0222 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0138 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0102 | 0.4571 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0104 | 0.0663 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0138 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.021 | 0.3026 | 0.2991 |
Echinococcus multilocularis | smad | 0.0045 | 0.0471 | 0.0508 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0202 | 0.291 | 0.2874 |
Loa Loa (eye worm) | Smad1 | 0.0045 | 0.0471 | 0.0422 |
Schistosoma mansoni | Smad4 | 0.002 | 0.0085 | 0.0042 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 0.1364 | 0.1586 |
Echinococcus multilocularis | GPCR, family 2 | 0.0066 | 0.0803 | 0.0909 |
Schistosoma mansoni | ran | 0.0021 | 0.0104 | 0.0065 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0659 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0045 | 0.0471 | 0.0422 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0102 | 0.0062 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0222 | 0.0208 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0104 | 0.312 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0159 | 0.011 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0102 | 0.4571 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0143 | 0.1997 | 0.1957 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0102 | 0.0052 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0104 | 0.0065 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.0102 | 0.0062 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0066 | 0.0803 | 0.0756 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0803 | 0.0909 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0138 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0222 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.002 | 0.0085 | 0.0042 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0102 | 0.1364 | 0.132 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0066 | 0.0803 | 0.0756 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0362 | 0.5389 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0102 | 0.4571 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0104 | 0.0663 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0104 | 0.0663 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 0.1364 | 0.1586 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0102 | 0.0052 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.1997 | 0.235 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0803 | 0.0909 |
Brugia malayi | TAR-binding protein | 0.0202 | 0.291 | 0.2874 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.0102 | 0.0062 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0104 | 0.0663 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0102 | 0.0062 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0138 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0202 | 0.291 | 0.3453 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0102 | 0.1364 | 0.132 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0803 | 0.0756 |
Brugia malayi | Smad1 | 0.0045 | 0.0471 | 0.0422 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0045 | 0.0471 | 0.0508 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0104 | 0.0054 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0102 | 0.0062 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0222 | 0.0173 |
Brugia malayi | MH2 domain containing protein | 0.002 | 0.0085 | 0.0035 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0102 | 0.4571 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0102 | 0.4571 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.021 | 0.3026 | 0.2991 |
Brugia malayi | MH2 domain containing protein | 0.0045 | 0.0471 | 0.0422 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0102 | 0.0062 |
Echinococcus granulosus | tar DNA binding protein | 0.0202 | 0.291 | 0.3453 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0045 | 0.0471 | 0.0508 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0803 | 0.0909 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0102 | 0.4571 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.1049 | 0.1004 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0102 | 0.5 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0104 | 0.0054 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0222 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0045 | 0.0471 | 0.0422 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0104 | 0.0663 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0102 | 0.4571 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0803 | 0.0909 |
Brugia malayi | MH1 domain containing protein | 0.0045 | 0.0471 | 0.0422 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0659 | 1 | 1 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0138 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.