Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | No references | |
Electrophorus electricus | Acetylcholinesterase | No references | |
Homo sapiens | beta-site APP-cleaving enzyme 1 | No references | |
Homo sapiens | acetylcholinesterase (Yt blood group) | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.3559 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0093 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3382 | 0.9503 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.3559 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.3559 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.3559 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0238 | 0.3382 | 0.3382 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.3559 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0238 | 0.3382 | 0.3382 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3382 | 0.9503 |
Onchocerca volvulus | 0.0208 | 0.2671 | 0.7897 | |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.3559 | 0.3559 |
Onchocerca volvulus | 0.0238 | 0.3382 | 1 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0093 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.3559 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.3559 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.3559 | 1 |
Brugia malayi | Trypsin family protein | 0.0238 | 0.3382 | 0.9503 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.3559 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.6 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 46.7 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 1100 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 1190 nM | ß-Secretase (BACE-1) | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.