Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.002 | 0.0412 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1809 | 0.1809 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.002 | 0.0412 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1809 | 0.5 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.002 | 0.0412 | 0.1574 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.7759 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0057 | 0.2616 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase NSD3 | 0.004 | 0.1581 | 0.6042 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1809 | 0.1809 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.013 | 0.6937 | 0.8837 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.002 | 0.0412 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0057 | 0.2616 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0057 | 0.2616 | 0.3284 |
Brugia malayi | glutathione reductase | 0.0057 | 0.2616 | 0.3284 |
Echinococcus multilocularis | histone lysine N methyltransferase NSD3 | 0.004 | 0.1581 | 0.6042 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0145 | 0.7796 | 1 |
Schistosoma mansoni | SET domain protein | 0.004 | 0.1581 | 0.1581 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0145 | 0.7796 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.013 | 0.6937 | 0.8837 |
Toxoplasma gondii | thioredoxin reductase | 0.0057 | 0.2616 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.002 | 0.0412 | 0.0405 |
Trichomonas vaginalis | glutathione reductase, putative | 0.002 | 0.0412 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0057 | 0.2616 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.002 | 0.0412 | 0.0412 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0057 | 0.2616 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1809 | 0.6916 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.013 | 0.6937 | 0.8837 |
Plasmodium vivax | glutathione reductase, putative | 0.0057 | 0.2616 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0145 | 0.7796 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1809 | 0.223 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.002 | 0.0412 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.013 | 0.6937 | 0.8837 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.7759 | 1 |
Treponema pallidum | NADH oxidase | 0.002 | 0.0412 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.002 | 0.0412 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0145 | 0.7796 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0057 | 0.2616 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.002 | 0.0412 | 0.5 |
Leishmania major | trypanothione reductase | 0.0057 | 0.2616 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1809 | 0.6916 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.002 | 0.0412 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1809 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.013 | 0.6937 | 0.8837 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0057 | 0.2616 | 0.2985 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.7759 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0057 | 0.2616 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1809 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1809 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.002 | 0.0412 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.013 | 0.6937 | 0.8837 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.002 | 0.0412 | 0.1574 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0057 | 0.2616 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.