Detailed information for compound 1906009

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.421 | Formula: C19H17N3O4S
  • H donors: 2 H acceptors: 3 LogP: 2.65 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N[C@H](C(=O)Nc1ccc(cc1)c1nsc(=O)o1)Cc1ccccc1
  • InChi: 1S/C19H17N3O4S/c1-12(23)20-16(11-13-5-3-2-4-6-13)17(24)21-15-9-7-14(8-10-15)18-22-27-19(25)26-18/h2-10,16H,11H2,1H3,(H,20,23)(H,21,24)/t16-/m0/s1
  • InChiKey: UTMWNVYSIIRNHA-INIZCTEOSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens proteasome (prosome, macropain) subunit, beta type, 8 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Theileria parva proteasome subunit beta type 5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania infantum proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Candida albicans proteasome subunit Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania braziliensis proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium yoelii proteosome PSMB5/8 protein Get druggable targets OG5_127100 All targets in OG5_127100
Neospora caninum Family T1, proteasome beta subunit, threonine peptidase, related Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium falciparum proteasome subunit beta type-5 Get druggable targets OG5_127100 All targets in OG5_127100
Brugia malayi Proteasome A-type and B-type family protein Get druggable targets OG5_127100 All targets in OG5_127100
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase Get druggable targets OG5_127100 All targets in OG5_127100
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania major proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Mycobacterium leprae proteasome (beta subunit) PrcB Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma congolense proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma cruzi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania mexicana proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania donovani proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Babesia bovis proteasome epsilon subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Loa Loa (eye worm) proteasome A-type and B-type family protein Get druggable targets OG5_127100 All targets in OG5_127100
Candida albicans proteasome subunit Get druggable targets OG5_127100 All targets in OG5_127100
Echinococcus multilocularis proteasome (prosome, macropain) Get druggable targets OG5_127100 All targets in OG5_127100
Echinococcus granulosus proteasome prosome macropain Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma japonicum ko:K02737 20S proteasome subunit beta 5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma cruzi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Giardia lamblia Proteasome subunit beta type 5 precursor Get druggable targets OG5_127100 All targets in OG5_127100
Toxoplasma gondii proteasome subunit beta type, putative Get druggable targets OG5_127100 All targets in OG5_127100
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma brucei proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Mycobacterium ulcerans proteasome PrcB Get druggable targets OG5_127100 All targets in OG5_127100
Cryptosporidium parvum Pre2p/proteasome subunit beta type 5; NTN hydrolase fold Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium vivax proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma brucei gambiense proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium berghei proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii proteasome subunit beta type 1, putative proteasome (prosome, macropain) subunit, beta type, 8 272 aa 251 aa 23.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0142 0.3384 0.4963
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0134 0.3165 0.4641
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0154 0.3702 0.5429
Onchocerca volvulus 0.0021 0.0017 0.005
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0035 0.0399 0.0399
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0032 0.0314 0.0314
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0228 0.5786 0.5786
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0154 0.3702 0.5429
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0265 0.6819 0.6819
Echinococcus granulosus subfamily T1A non peptidase ue 0.0153 0.3674 0.3674
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0265 0.6819 1
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0035 0.0395 0.058
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0053 0.0053
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0039 0.0498 0.0731
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0032 0.0319 0.0468
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0273 0.0401
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0023 0.0053 0.0077
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0042 0.058 0.058
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0135 0.3191 0.3191
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0032 0.0314 0.0461
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0128 0.3001 0.4402
Giardia lamblia 20S proteasome alpha subunit 7 0.0142 0.3384 0.4963
Toxoplasma gondii proteasome subunit beta type, putative 0.0265 0.6819 1
Plasmodium vivax proteasome subunit beta type-3, putative 0.0134 0.3165 0.4641
Echinococcus multilocularis proteasome subunit beta type 6 0.0141 0.3349 0.3349
Leishmania major proteasome alpha 2 subunit, putative 0.0146 0.3484 0.5109
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0128 0.3001 0.4402
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0023 0.0051 0.0074
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0036 0.0435 0.0639
Toxoplasma gondii PCI domain-containing protein 0.0039 0.0498 0.0731
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0042 0.058 0.085
Schistosoma mansoni hypothetical protein 0.0032 0.0314 0.0314
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0035 0.0399 0.0585
Giardia lamblia Proteasome subunit beta type 3 0.0134 0.3165 0.4641
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0154 0.3702 0.5429
Echinococcus granulosus Proteasome subunit alpha type 7 0.0193 0.4797 0.4797
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.014 0.3336 0.3336
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0154 0.3702 0.5429
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0134 0.3165 0.4641
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0025
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0036 0.0435 0.0639
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0032 0.0319 0.0468
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0035 0.0399 0.0585
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0164 0.3981 0.5839
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0021 0.0017 0.0017
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0039 0.0498 0.0731
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0142 0.3384 0.4963
Echinococcus multilocularis adhesion regulating molecule 1 0.01 0.222 0.222
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0132 0.3115 0.4568
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0128 0.3001 0.4402
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0141 0.3349 0.4911
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0141 0.3349 0.4911
Plasmodium vivax proteasome subunit beta type-1, putative 0.0164 0.3981 0.5839
Schistosoma mansoni hypothetical protein 0.0093 0.2013 0.2013
Loa Loa (eye worm) PCI domain-containing protein 0.0035 0.0399 0.0585
Leishmania major proteasome beta 2 subunit, putative 0.0128 0.3001 0.4402
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0021 0.0017 0.0017
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0021 0.0017 0.0025
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0379 1 1
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0021 0.0017 0.0025
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0146 0.3484 0.5109
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0021 0.0017 0.0017
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0035 0.0395 0.0395
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0039 0.0498 0.0498
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0035 0.0395 0.0395
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0193 0.4797 0.4797
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0017 0.0025
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0128 0.3001 0.4402
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0042 0.058 0.058
Giardia lamblia 26S protease regulatory subunit 6B 0.0021 0.0017 0.0025
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0035 0.0395 0.058
Echinococcus granulosus proteasome prosome macropain 0.0265 0.6819 0.6819
Leishmania major proteasome alpha 7 subunit, putative 0.0142 0.3384 0.4963
Loa Loa (eye worm) proteasome subunit beta type 3 0.0134 0.3165 0.4641
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0023 0.0053 0.0077
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0023 0.0053 0.0077
Leishmania major proteasome beta 7 subunit, putative 0.0132 0.3115 0.4568
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0064 0.1198 0.354
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0193 0.4797 0.7035
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0021 0.0017 0.0025
Brugia malayi PCI domain containing protein 0.0032 0.0314 0.0314
Echinococcus multilocularis proteasome subunit beta type 7 0.0379 1 1
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0042 0.058 0.058
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0032 0.0319 0.0319
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0153 0.3674 0.5387
Giardia lamblia 20S proteasome alpha subunit 5 0.0153 0.3674 0.5387
Echinococcus granulosus 20S proteasome subunit alpha 6 0.014 0.3321 0.3321
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0164 0.3981 0.5839
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0021 0.0017 0.0025
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0273 0.0401
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0042 0.058 0.085
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0023 0.0051 0.0074
Toxoplasma gondii proteasome subunit alpha1, putative 0.0154 0.3702 0.5429
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0141 0.3349 0.4911
Plasmodium vivax proteasome subunit beta type-6, putative 0.0141 0.3349 0.4911
Loa Loa (eye worm) proteasome Regulatory Particle 0.0035 0.0395 0.058
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0146 0.3484 0.5109
Brugia malayi 26S protease regulatory subunit 6A 0.0023 0.0053 0.0053
Entamoeba histolytica proteasome regulatory subunit, putative 0.0023 0.0051 0.0074
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0193 0.4797 0.4797
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0021 0.0017 0.0025
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0134 0.3165 0.4641
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0142 0.3384 0.4963
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0146 0.3484 0.5109
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0035 0.0399 0.0585
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0154 0.3702 0.5429
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0164 0.3981 0.3981
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0134 0.3165 0.4641
Giardia lamblia 26S protease regulatory subunit 6A 0.0023 0.0053 0.0077
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0319 0.0468
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0146 0.3484 0.5109
Onchocerca volvulus 0.0021 0.0017 0.005
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0134 0.3165 0.4641
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0319 0.0468
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0132 0.3115 0.4568
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0141 0.3349 0.4911
Giardia lamblia 20S proteasome alpha subunit 4 0.0193 0.4797 0.7035
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0128 0.3001 0.4402
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0153 0.3674 0.5387
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0134 0.3165 0.4641
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0032 0.0314 0.0314
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.014 0.3336 0.3336
Brugia malayi PCI domain containing protein 0.0035 0.0399 0.0399
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0164 0.3981 0.3981
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0032 0.0319 0.0468
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0021 0.0017 0.0025
Brugia malayi 26S proteasome subunit P45 family protein 0.0021 0.0017 0.0017
Toxoplasma gondii SAC3/GANP family protein 0.0031 0.0273 0.0401
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0134 0.3165 0.3164
Brugia malayi Probable 26S protease regulatory subunit 4 0.0021 0.0017 0.0017
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0042 0.058 0.085
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0134 0.3165 0.4641
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.014 0.3321 0.4871
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0106 0.2377 0.3486
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.014 0.3321 0.3321
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0035 0.0399 0.0585
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0031 0.0273 0.0273
Loa Loa (eye worm) RPN-3 protein 0.0042 0.058 0.085
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0023 0.0053 0.0077
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0128 0.3001 0.4402
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0032 0.0319 0.0319
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0039 0.0498 0.0731
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0193 0.4797 0.7035
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0031 0.0273 0.0401
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.014 0.3321 0.4871
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0017 0.0025
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0106 0.2377 0.3486
Entamoeba histolytica proteasome regulatory subunit, putative 0.0039 0.0498 0.0731
Loa Loa (eye worm) hypothetical protein 0.0028 0.0208 0.0304
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0154 0.3702 0.5429
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0032 0.0314 0.0461
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0036 0.0435 0.0639
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0153 0.3674 0.3674
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0265 0.6819 1
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0042 0.058 0.058
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0164 0.3981 0.5839
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0036 0.0435 0.0639
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0134 0.3165 0.3164
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0039 0.0498 0.0731
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0017 0.0025
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0146 0.3484 0.5109
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0023 0.0051 0.0051
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.01 0.222 0.3256
Echinococcus multilocularis proteasome subunit alpha type 6 0.0154 0.3702 0.3702
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0035 0.0395 0.058
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0319 0.0468
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0035 0.0395 0.0395
Trypanosoma brucei proteasome beta 6 subunit 0.0164 0.3981 0.5839
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0132 0.3115 0.4568
Echinococcus granulosus proteasome subunit alpha type 6 0.0154 0.3702 0.3702
Plasmodium vivax proteasome subunit alpha type-4, putative 0.014 0.3336 0.4892
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0319 0.0468
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0036 0.0435 0.0639
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0134 0.3165 0.4641
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0036 0.0435 0.0639
Toxoplasma gondii proteasome subunit alpha type, putative 0.014 0.3336 0.4892
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0023 0.0053 0.0077
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0032 0.0319 0.0468
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0273 0.0401
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0193 0.4797 0.7035
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0319 0.0319
Loa Loa (eye worm) proteasome regulatory particle 0.0039 0.0498 0.0731
Brugia malayi Ubiquitin interaction motif family protein 0.0023 0.0051 0.0051
Leishmania major proteasome beta 2 subunit, putative 0.0134 0.3165 0.4641
Brugia malayi Proteasome A-type and B-type family protein 0.0141 0.3349 0.3349
Toxoplasma gondii proteasome subunit alpha type, putative 0.0087 0.184 0.2699
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0319 0.0468
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0039 0.0498 0.0731
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0021 0.0017 0.0025
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0146 0.3484 0.5109
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0265 0.6819 1
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0035 0.0395 0.058
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0142 0.3384 0.4963
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0142 0.3384 0.4963
Echinococcus multilocularis proteasome (prosome, macropain) 0.0265 0.6819 0.6819
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0134 0.3165 0.3164
Loa Loa (eye worm) hypothetical protein 0.01 0.222 0.3256
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0134 0.3165 0.4641
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0036 0.0435 0.0435
Schistosoma mansoni proteasome regulatory subunit-related 0.0035 0.0399 0.0399
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0021 0.0000046814 0.0000068654
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0021 0.0017 0.0025
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0035 0.0395 0.0395
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0031 0.0273 0.0401
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0141 0.3349 0.4911
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0035 0.0395 0.058
Trypanosoma cruzi 20S proteasome subunit 0.0134 0.3165 0.4641
Toxoplasma gondii proteasome regulatory subunit 0.0032 0.0319 0.0468
Toxoplasma gondii PCI domain-containing protein 0.0032 0.0314 0.0461
Loa Loa (eye worm) hypothetical protein 0.0228 0.5786 0.8485
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0193 0.4797 0.7035
Loa Loa (eye worm) RPT-2 protein 0.0021 0.0017 0.0025
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0265 0.6819 1
Brugia malayi proteasome subunit alpha type 6 0.0154 0.3702 0.3702
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0021 0.0017 0.0017
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0146 0.3484 0.3484
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.014 0.3336 0.4892
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0031 0.0273 0.0401
Giardia lamblia Proteasome subunit beta type 1 0.0164 0.3981 0.5839
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0022 0.0034 0.005
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.014 0.3321 0.4871
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0319 0.0319
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0193 0.4797 0.7035
Schistosoma mansoni 26S protease regulatory subunit 0.0021 0.0017 0.0017
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0052 0.0879 0.1289
Leishmania major proteasome alpha 1 subunit, putative 0.0154 0.3702 0.5429
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0032 0.0314 0.0461
Giardia lamblia 20S proteasome alpha subunit 6 0.014 0.3321 0.4871
Echinococcus granulosus adhesion regulating molecule 1 0.01 0.222 0.222
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0053 0.0053
Brugia malayi Proteasome A-type and B-type family protein 0.0132 0.3115 0.3115
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0035 0.0395 0.058
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.014 0.3336 0.4892
Leishmania major hypothetical protein, conserved 0.0052 0.0879 0.1289
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0021 0.0017 0.0025
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0022 0.0034 0.005
Echinococcus granulosus proteasome subunit alpha type 2 0.0146 0.3484 0.3484
Loa Loa (eye worm) PCI domain-containing protein 0.0032 0.0314 0.0461
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0154 0.3702 0.5429
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0021 0.0017 0.0025
Giardia lamblia Hypothetical protein 0.0039 0.0498 0.0731
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0395 0.058
Trichomonas vaginalis 26S proteasome subunit, putative 0.0032 0.0314 0.0461
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0132 0.3115 0.4568
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0128 0.3001 0.4402
Mycobacterium ulcerans proteasome PrcB 0.0265 0.6819 1
Plasmodium vivax proteasome subunit beta type-5, putative 0.0265 0.6819 1
Trypanosoma brucei proteasome alpha 7 subunit 0.0142 0.3384 0.4963
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0039 0.0498 0.0498
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0032 0.0319 0.0468
Brugia malayi proteasome subunit alpha type 1 0.014 0.3321 0.3321
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0023 0.0053 0.0053
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0036 0.0435 0.0639
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0134 0.3165 0.3164
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0132 0.3115 0.3115
Schistosoma mansoni multiubiquitin binding protein S5a 0.0023 0.0051 0.0051
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0036 0.0435 0.0639
Leishmania major proteasome alpha 3 subunit, putative 0.014 0.3336 0.4892
Brugia malayi proteasome subunit alpha type 3 0.0142 0.3384 0.3384
Brugia malayi proteasome subunit beta type 1 0.0164 0.3981 0.3981
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0032 0.0314 0.0461
Brugia malayi Adhesion regulating molecule conserved region family protein 0.01 0.222 0.222
Giardia lamblia Proteasome subunit beta type 2 0.0134 0.3165 0.4641
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0106 0.2377 0.3486
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0023 0.0051 0.0051
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0193 0.4797 0.4797
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0153 0.3674 0.5387
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0023 0.0053 0.0077
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0031 0.0273 0.0273
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0193 0.4797 0.7035
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0154 0.3702 0.3702
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0031 0.0273 0.0273
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0128 0.3001 0.4402
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0123 0.2859 0.4193
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0106 0.2377 0.2377
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0023 0.0053 0.0077
Giardia lamblia 20S proteasome alpha subunit 2 0.0146 0.3484 0.5109
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0153 0.3674 0.5387
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0193 0.4797 0.7035
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0142 0.3384 0.3384
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0032 0.0319 0.0468
Leishmania major proteasome beta 5 subunit, putative 0.0265 0.6819 1
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0023 0.0053 0.0053
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0265 0.6819 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0021 0.0017 0.0025
Toxoplasma gondii hypothetical protein 0.0028 0.0208 0.0304
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0134 0.3165 0.3164
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0142 0.3384 0.4963
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0134 0.3165 0.4641
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.014 0.3336 0.3336
Leishmania major proteasome alpha 1 subunit, putative 0.014 0.3321 0.4871
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0031 0.0273 0.0401
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0399 0.0585
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0106 0.2377 0.3486
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0031 0.0289 0.0423
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0132 0.3115 0.3115
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0035 0.0395 0.058
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0193 0.4797 0.7035
Plasmodium vivax proteasome subunit beta type-7, putative 0.0128 0.3001 0.4402
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0017 0.0025
Echinococcus multilocularis proteasome subunit alpha type 2 0.0146 0.3484 0.3484
Brugia malayi proteasome subunit beta type 2 0.0134 0.3165 0.3164
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0164 0.3981 0.5839
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0106 0.2377 0.3486
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0035 0.0399 0.0399
Toxoplasma gondii peptidase, T1 family protein 0.0142 0.3384 0.4963
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0036 0.0435 0.0435
Brugia malayi 20S proteasome alpha5 subunit 0.0153 0.3674 0.3674
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.014 0.3321 0.4871
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.014 0.3321 0.3321
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0142 0.3384 0.3384
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0141 0.3349 0.4911
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0036 0.0435 0.0435
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0017 0.0025
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0132 0.3115 0.4568
Toxoplasma gondii PCI domain-containing protein 0.0042 0.058 0.085
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0053 0.0053
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0031 0.0273 0.0273
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0132 0.3115 0.3115
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.014 0.3321 0.4871
Loa Loa (eye worm) hypothetical protein 0.0031 0.0273 0.0401
Toxoplasma gondii proteasome 26S regulatory subunit 0.0022 0.0034 0.005
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0319 0.0468
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0153 0.3674 0.5387
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0032 0.0314 0.0461
Leishmania major proteasome beta-1 subunit, putative 0.0141 0.3349 0.4911
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0042 0.058 0.058
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.014 0.3336 0.4892
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0153 0.3674 0.3674
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.014 0.3321 0.4871
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0319 0.0468
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0134 0.3165 0.4641
Plasmodium vivax proteasome subunit beta type-2, putative 0.0134 0.3165 0.4641
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0039 0.0498 0.0731
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0319 0.0468
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0146 0.3484 0.5109
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0036 0.0435 0.0435
Brugia malayi Proteasome subunit alpha type 7-1 0.0193 0.4797 0.4797
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0032 0.0314 0.0461
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0164 0.3981 0.5839
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0093 0.2013 0.2013
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0314 0.0461
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0153 0.3674 0.5387
Brugia malayi proteasome subunit alpha type 2 0.0146 0.3484 0.3484
Brugia malayi Proteasome A-type and B-type family protein 0.0265 0.6819 0.6819
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0128 0.3001 0.4402
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0193 0.4797 0.7035
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.014 0.3336 0.4892
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.014 0.3336 0.4892
Brugia malayi proteasome subunit beta type 3 0.0134 0.3165 0.3164
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0265 0.6819 1
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0106 0.2377 0.3486
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0035 0.0399 0.0585
Toxoplasma gondii proteasome beta subunit 0.0134 0.3165 0.4641
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0035 0.0395 0.058
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0141 0.3349 0.3349
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0017 0.0025
Brugia malayi Proteasome subunit alpha type 1 0.0123 0.2839 0.2839
Loa Loa (eye worm) PAS-3 protein 0.0123 0.2854 0.4185
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0021 0.0017 0.0017
Loa Loa (eye worm) proteasome subunit beta type 1 0.0164 0.3981 0.5839
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.01 0.222 0.222
Trypanosoma brucei proteasome beta 7 subunit 0.0132 0.3115 0.4568
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0265 0.6819 1
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0023 0.0052 0.0076
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.014 0.3336 0.4892
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0142 0.3384 0.4963
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0153 0.3674 0.5387
Loa Loa (eye worm) proteasome subunit alpha type 1 0.014 0.3321 0.4871
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0035 0.0399 0.0585
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0154 0.3702 0.5429
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0042 0.058 0.085
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0093 0.2013 0.2013
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0153 0.3674 0.3674
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0032 0.0319 0.0319
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0036 0.0435 0.0435
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0153 0.3674 0.5387
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0319 0.0319
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0023 0.0053 0.0077
Loa Loa (eye worm) proteasome 26S subunit 0.0021 0.0000046814 0.0000068654
Plasmodium vivax proteasome subunit alpha type-1, putative 0.014 0.3321 0.4871
Brugia malayi proteasome subunit alpha type 4 0.0123 0.2854 0.2854
Giardia lamblia 20S proteasome alpha subunit 3 0.014 0.3336 0.4892
Plasmodium vivax proteasome subunit beta type-4, putative 0.0132 0.3115 0.4568
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0106 0.2377 0.3486
Leishmania major proteasome beta 3 subunit, putative 0.0134 0.3165 0.4641
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0319 0.0468
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0134 0.3165 0.3164
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0142 0.3384 0.4963
Giardia lamblia 20S proteasome alpha subunit 1 0.0154 0.3702 0.5429
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0134 0.3165 0.4641
Entamoeba histolytica proteasome regulatory subunit, putative 0.0042 0.058 0.085
Onchocerca volvulus Notchless protein homolog 0.0142 0.3384 1
Toxoplasma gondii heat shock protein hslv, putative 0.0106 0.2377 0.3486
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0021 0.0017 0.0025
Plasmodium falciparum proteasome subunit beta type-5 0.0265 0.6819 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0265 0.6819 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0134 0.3165 0.4641
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0023 0.0053 0.0077
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0141 0.3349 0.4911
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0106 0.2377 0.5
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0031 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0031 0.0273 0.0401
Loa Loa (eye worm) proteasome subunit beta type 2 0.0134 0.3165 0.4641
Schistosoma mansoni hypothetical protein 0.0228 0.5786 0.5786
Echinococcus granulosus proteasome subunit beta type 7 0.0379 1 1
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0032 0.0319 0.0319
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0039 0.0498 0.0498
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0017 0.0025
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0164 0.3981 0.3981
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0273 0.0401
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0035 0.0399 0.0585
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0265 0.6819 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0128 0.3001 0.4402
Echinococcus granulosus Proteasome subunit alpha beta 0.0142 0.3384 0.3384
Toxoplasma gondii proteasome subunit 0.0141 0.3349 0.4911
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0017 0.0025
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.014 0.3336 0.4892
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0023 0.0051 0.0074
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0134 0.3165 0.3164
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0032 0.0319 0.0319
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0164 0.3981 0.5839
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0141 0.3349 0.4911
Echinococcus granulosus proteasome subunit beta t family 0.0134 0.3165 0.3164
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0153 0.3674 0.5387
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0164 0.3981 0.5839
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0153 0.3674 0.5387
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0023 0.0053 0.0077
Leishmania major proteasome alpha 7 subunit, putative 0.0193 0.4797 0.7035
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0023 0.0051 0.0051
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0036 0.0435 0.0435
Schistosoma mansoni 26S proteasome subunit S9 0.0039 0.0498 0.0498
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0132 0.3115 0.4568
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0153 0.3674 0.5387
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0025
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0031 0.0273 0.0401
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0193 0.4797 0.4797
Plasmodium falciparum proteasome subunit beta type-4 0.0132 0.3115 0.4568
Echinococcus granulosus proteasome subunit beta type 6 0.0141 0.3349 0.3349

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.52 uM Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 mins by fluorescence analysis ChEMBL. 24900849
Kinact (binding) = 0.1 10'3/s Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 mins by fluorescence analysis ChEMBL. 24900849
Ratio (binding) = 193.3 /M/s Ratio of Kinact to Ki for immunoproteasome-20S subunit beta5i in human PBMC using suc-LLVY-AMC as substrate measured for 120 mins by fluorescence analysis ChEMBL. 24900849

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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