Detailed information for compound 1907133

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 537.558 | Formula: C29H31NO9
  • H donors: 1 H acceptors: 2 LogP: 4.32 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1NC(=O)/C=C/c1cc(OC)c(c(c1)OC)OC)C(=O)c1cc(OC)c(c(c1)OC)OC
  • InChi: 1S/C29H31NO9/c1-33-21-10-9-18(27(32)19-15-24(36-4)29(39-7)25(16-19)37-5)14-20(21)30-26(31)11-8-17-12-22(34-2)28(38-6)23(13-17)35-3/h8-16H,1-7H3,(H,30,31)/b11-8+
  • InChiKey: CWXFSLXABKJDBZ-DHZHZOJOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0135 0.2268 0.3104
Echinococcus granulosus dna polymerase kappa 0.0104 0.1632 0.2175
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.0151 0.0157
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0104 0.1632 0.2234
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0965 0.1495
Trypanosoma cruzi DNA polymerase eta, putative 0.0186 0.3325 0.5369
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0104 0.1632 0.259
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.1067 0.1168
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0212 0.387 0.6265
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0203 0.0388
Schistosoma mansoni tar DNA-binding protein 0.0135 0.2268 0.3104
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0028 0.0056 0.5
Schistosoma mansoni rotamase 0.0036 0.022 0.0302
Schistosoma mansoni jumonji domain containing protein 0.0165 0.2888 0.3952
Loa Loa (eye worm) hypothetical protein 0.0064 0.0809 0.087
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.042 0.06
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0056 0.0001
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0028 0.0056 0.0007
Leishmania major DNA polymerase kappa, putative 0.0032 0.0151 0.0157
Brugia malayi glutathione reductase 0.008 0.1134 0.1245
Brugia malayi PHD-finger family protein 0.0063 0.0792 0.085
Loa Loa (eye worm) hypothetical protein 0.0152 0.2621 0.2961
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0114 0.1843 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0212 0.387 0.5261
Trichomonas vaginalis rotamase, putative 0.0035 0.0203 0.0149
Echinococcus multilocularis transcription factor Dp 1 0.0123 0.2023 0.2713
Giardia lamblia DINP protein human, muc B family 0.0104 0.1632 1
Leishmania major trypanothione reductase 0.008 0.1134 0.1772
Echinococcus granulosus thioredoxin glutathione reductase 0.0081 0.1156 0.1519
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.1632 0.259
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.0792 0.1084
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0056 0.5
Toxoplasma gondii thioredoxin reductase 0.008 0.1134 0.6035
Brugia malayi jmjC domain containing protein 0.0077 0.1067 0.1168
Trypanosoma brucei DNA polymerase eta, putative 0.0186 0.3325 0.5369
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0151 0.0157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.1632 0.259
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0809 0.4216
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0182 0.3249 0.8837
Brugia malayi Pre-SET motif family protein 0.0447 0.8723 1
Echinococcus granulosus transcription factor Dp 1 0.0123 0.2023 0.2713
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0056 0.5
Echinococcus multilocularis geminin 0.0378 0.7308 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0104 0.1632 0.4134
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0202 0.3669 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0056 0.0001
Trypanosoma brucei chrX additional, unordered contigs 0.0032 0.0151 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.022 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1632 0.259
Brugia malayi ImpB/MucB/SamB family protein 0.0186 0.3325 0.3772
Mycobacterium ulcerans hypothetical protein 0.0032 0.0151 0.0323
Toxoplasma gondii hypothetical protein 0.0052 0.0558 0.2814
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0056 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0444 0.0537
Treponema pallidum NADH oxidase 0.0028 0.0056 0.5
Trichomonas vaginalis glutathione reductase, putative 0.0028 0.0056 0.0001
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.022 0.0191
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0212 0.387 0.4402
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.2268 0.2553
Leishmania major mitochondrial DNA polymerase beta 0.0322 0.6145 1
Trypanosoma brucei unspecified product 0.0104 0.1632 0.259
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.013 0.2175 0.2923
Plasmodium vivax glutathione reductase, putative 0.008 0.1134 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0212 0.387 0.6265
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.1067 0.1461
Mycobacterium tuberculosis Conserved hypothetical protein 0.0104 0.1632 0.4363
Brugia malayi ImpB/MucB/SamB family protein 0.0104 0.1632 0.182
Plasmodium falciparum phd finger protein, putative 0.0063 0.0792 0.683
Loa Loa (eye worm) hypothetical protein 0.0152 0.2621 0.2961
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0182 0.3249 0.8837
Onchocerca volvulus 0.0161 0.2817 0.2199
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0212 0.387 0.5296
Brugia malayi Muscleblind-like protein 0.0152 0.2621 0.2961
Plasmodium falciparum thioredoxin reductase 0.008 0.1134 1
Echinococcus granulosus tar DNA binding protein 0.0135 0.2268 0.3051
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0212 0.387 0.6265
Mycobacterium tuberculosis Probable oxidoreductase 0.0202 0.3669 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.0792 0.1016
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0792 0.085
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0151 0.0157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0056 0.0001
Echinococcus granulosus muscleblind protein 0.0152 0.2621 0.3539
Trichomonas vaginalis mercuric reductase, putative 0.0028 0.0056 0.0001
Brugia malayi TAR-binding protein 0.0135 0.2268 0.2553
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0056 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.1632 0.259
Plasmodium falciparum thioredoxin reductase 0.0028 0.0056 0.0007
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0203 0.0243
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.1632 0.5368
Echinococcus multilocularis expressed protein 0.0036 0.022 0.0228
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0212 0.387 0.4402
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0444 0.0537
Schistosoma mansoni tar DNA-binding protein 0.0135 0.2268 0.3104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0056 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0444 0.0537
Trypanosoma brucei unspecified product 0.0072 0.0965 0.1495
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0809 0.1107
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0444 0.0449
Plasmodium vivax DNA repair protein REV1, putative 0.0032 0.0151 0.0886
Schistosoma mansoni hypothetical protein 0.0378 0.7308 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0444 0.0449
Schistosoma mansoni tar DNA-binding protein 0.0135 0.2268 0.3104
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0202 0.3669 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0444 0.0608
Brugia malayi Bromodomain containing protein 0.0063 0.0792 0.085
Mycobacterium tuberculosis Conserved hypothetical protein 0.017 0.2993 0.8128
Trichomonas vaginalis DNA polymerase eta, putative 0.0104 0.1632 0.1586
Onchocerca volvulus 0.0064 0.0809 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0151 0.0157
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0203 0.0243
Loa Loa (eye worm) RNA binding protein 0.0135 0.2268 0.2553
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.2268 0.2553
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.1632 0.259
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0056 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0792 0.683
Echinococcus multilocularis lysine specific demethylase 5A 0.0077 0.1067 0.1396
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.0151 0.0157
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.042 0.06
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0056 0.0001
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0028 0.0056 0.0001
Loa Loa (eye worm) TAR-binding protein 0.0135 0.2268 0.2553
Echinococcus granulosus peregrin 0.0063 0.0792 0.1016
Echinococcus multilocularis dna polymerase kappa 0.0104 0.1632 0.2175
Echinococcus multilocularis muscleblind protein 1 0.0152 0.2621 0.3539
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.042 0.06
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0444 0.0608
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0792 0.4122
Echinococcus multilocularis dna polymerase eta 0.0186 0.3325 0.4509
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0056 0.0001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0104 0.1632 0.182
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1632 0.259
Trypanosoma brucei trypanothione reductase 0.008 0.1134 0.1772
Brugia malayi polk-prov protein 0.0032 0.0151 0.011
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0182 0.3249 0.8837
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0104 0.1632 0.2175
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.076 0.0972
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0965 0.1495
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0809 0.104
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.008 0.1134 0.2985
Echinococcus granulosus arachidonate 5 lipoxygenase 0.013 0.2175 0.2923
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0028 0.0056 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0809 0.1107
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0322 0.6145 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0028 0.0056 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.1632 0.5368
Echinococcus granulosus dna polymerase eta 0.0186 0.3325 0.4509
Trichomonas vaginalis rotamase, putative 0.0036 0.022 0.0166
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0809 0.1107
Loa Loa (eye worm) glutathione reductase 0.008 0.1134 0.1245
Echinococcus granulosus PHD finger protein rhinoceros 0.0063 0.0792 0.1016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0182 0.3249 0.8837
Loa Loa (eye worm) jmjC domain-containing protein 0.0131 0.2185 0.2457
Leishmania major DNA polymerase eta, putative 0.0186 0.3325 0.5369
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.1632 0.259
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1632 0.259
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0028 0.0056 0.0001
Echinococcus multilocularis tar DNA binding protein 0.0135 0.2268 0.3051
Leishmania major DNA polymerase eta, putative 0.0114 0.1843 0.2936
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0203 0.0243
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.0151 0.0157
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.2636 0.4239
Schistosoma mansoni terminal deoxycytidyl transferase 0.0104 0.1632 0.2234
Schistosoma mansoni tar DNA-binding protein 0.0135 0.2268 0.3104
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0028 0.0056 0.0076
Leishmania major DNA polymerase kappa, putative 0.0104 0.1632 0.259
Plasmodium falciparum glutathione reductase 0.0028 0.0056 0.0007
Loa Loa (eye worm) hypothetical protein 0.0063 0.0792 0.085
Echinococcus granulosus expressed protein 0.0036 0.022 0.0228
Giardia lamblia NADH oxidase lateral transfer candidate 0.0028 0.0056 0.0005
Brugia malayi hypothetical protein 0.0161 0.2817 0.3186
Toxoplasma gondii NADPH-glutathione reductase 0.0028 0.0056 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1632 0.259
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0056 0.0001
Schistosoma mansoni lipoxygenase 0.0091 0.1365 0.1868
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0104 0.1632 0.4363
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.1632 0.259
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1632 0.259
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.0151 0.0535
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0212 0.387 0.6265
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0202 0.3669 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0028 0.0056 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0444 0.0608
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0151 0.0157
Trypanosoma cruzi DNA polymerase eta, putative 0.0114 0.1843 0.2936
Trypanosoma brucei unspecified product 0.0072 0.0965 0.1495
Trypanosoma cruzi trypanothione reductase, putative 0.008 0.1134 0.1772
Echinococcus granulosus lysine specific demethylase 5A 0.0077 0.1067 0.1396
Loa Loa (eye worm) hypothetical protein 0.0108 0.1727 0.1929
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0444 0.0537
Plasmodium vivax SET domain protein, putative 0.0064 0.0809 0.6986
Schistosoma mansoni hypothetical protein 0.0063 0.0792 0.1084
Schistosoma mansoni DNA polymerase IV / kappa 0.0032 0.0151 0.0206
Echinococcus multilocularis peregrin 0.0063 0.0792 0.1016
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0028 0.0056 0.0001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0151 0.011
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.0151 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0809 0.1107
Schistosoma mansoni lipoxygenase 0.013 0.2175 0.2976
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1632 0.259
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.022 0.0191
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0104 0.1632 0.1586
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0207 0.3769 0.5121
Echinococcus granulosus jumonji domain containing protein 0.0088 0.1304 0.1723
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1632 0.259
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1632 0.259
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0028 0.0056 0.0001
Loa Loa (eye worm) thioredoxin reductase 0.008 0.1134 0.1245
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.6145 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0081 0.1156 0.1519
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0447 0.8723 1
Brugia malayi jmjC domain containing protein 0.0207 0.3769 0.4284
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0203 0.0243
Schistosoma mansoni DNA polymerase eta 0.0186 0.3325 0.455
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0028 0.0056 0.0007
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0028 0.0056 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.1067 0.1461
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.0056 0.0001
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0792 0.4122
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1632 0.259
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0809 0.104
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.2636 0.4239
Plasmodium vivax thioredoxin reductase, putative 0.008 0.1134 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0207 0.3769 0.5121
Mycobacterium tuberculosis Probable dehydrogenase 0.0182 0.3249 0.8837
Echinococcus granulosus geminin 0.0378 0.7308 1
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.1632 0.259
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.2636 0.4239
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0965 0.1495
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.042 0.06
Echinococcus multilocularis jumonji domain containing protein 0.0088 0.1304 0.1723
Trichomonas vaginalis set domain proteins, putative 0.0508 1 1
Mycobacterium tuberculosis Probable reductase 0.0182 0.3249 0.8837
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0056 0.0001
Giardia lamblia DNA damage repair protein 0.0032 0.0151 0.0606
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0056 0.0001
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0104 0.1632 0.2175
Echinococcus multilocularis muscleblind protein 0.0152 0.2621 0.3539
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0212 0.387 0.5261
Loa Loa (eye worm) hypothetical protein 0.0161 0.2817 0.3186
Brugia malayi Thioredoxin reductase 0.008 0.1134 0.1245
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0151 0.0157
Giardia lamblia PHD finger protein 15 0.0063 0.0792 0.4673
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.1632 0.259
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0203 0.0829
Loa Loa (eye worm) hypothetical protein 0.0186 0.3325 0.3772
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0028 0.0056 0.0004
Schistosoma mansoni hypothetical protein 0.0378 0.7308 1
Brugia malayi RNA binding protein 0.0135 0.2268 0.2553
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0809 0.104
Plasmodium falciparum DNA repair protein REV1, putative 0.0032 0.0151 0.0886
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0151 0.0535
Leishmania major DNA damage repair protein, putative 0.0032 0.0151 0.0157
Mycobacterium ulcerans hypothetical protein 0.017 0.2993 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.6145 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0212 0.387 1
Plasmodium falciparum glutathione reductase 0.008 0.1134 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0625 0.0937
Brugia malayi Pre-SET motif family protein 0.0064 0.0809 0.087
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0151 0.0157
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0028 0.0056 0.0007

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.2 uM Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay ChEMBL. 24736114
IC50 (functional) = 1.5 uM Cytotoxicity against human HeLa cells after 72 hrs by MTT assay ChEMBL. 24736114

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 24736114
Homo sapiens ChEMBL23 24736114

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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