Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0086 | 0.7743 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0096 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0096 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0096 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.006 | 0.2407 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.006 | 0.2407 | 0.2407 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0096 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0048 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0086 | 0.7743 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0049 | 0.0151 | 0.0151 |
Brugia malayi | FAD binding domain containing protein | 0.0096 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0096 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0096 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0096 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0096 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0096 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0048 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0096 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0096 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0096 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0096 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0096 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0096 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 uM | Exogenous inhibition concentration of Serine/threonine protein phosphatase 1 (PP1). Potency is described as high micro molar to milli molar | ChEMBL. | 11881984 |
IC50 (binding) | 0 uM | Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A). Potency is described as high micro molar to milli molar | ChEMBL. | 11881984 |
ND (binding) | 0 | Exogenous inhibition concentration of Serine/threonine protein phosphatase 2B (PP2B); ND means not determined | ChEMBL. | 11881984 |
ND (binding) | 0 | Exogenous inhibition concentration of Serine/threonine protein phosphatase 2C (PP2C); ND means not determined | ChEMBL. | 11881984 |
ND (binding) | 0 | Exogenous inhibition concentration of Serine/threonine protein phosphatase 4 (PP4); ND means not determined | ChEMBL. | 11881984 |
ND (binding) | 0 | Exogenous inhibition concentration of Serine/threonine protein phosphatase 5 (PP5); ND means not determined | ChEMBL. | 11881984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.