Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RAR-related orphan receptor C | Starlite/ChEMBL | References |
Homo sapiens | RAR-related orphan receptor A | Starlite/ChEMBL | References |
Homo sapiens | RAR-related orphan receptor B | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Schistosoma japonicum | Ecdysone-induced protein 78C, putative | Get druggable targets OG5_134341 | All targets in OG5_134341 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Echinococcus granulosus | thyroid hormone receptor alpha | Get druggable targets OG5_134341 | All targets in OG5_134341 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | steroid hormone receptor | Get druggable targets OG5_134341 | All targets in OG5_134341 |
Loa Loa (eye worm) | steroid hormone receptor | Get druggable targets OG5_134341 | All targets in OG5_134341 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | RAR-related orphan receptor B | 459 aa | 403 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0196 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0244 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | Agonist activity at human LXR-beta expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay | ChEMBL. | 24702856 | |
IC50 (binding) | = 0.68 uM | Antagonist activity at human LXR-beta expressed in HEK293 cells assessed as inhibition of T0901317-induced effect after 16 hrs by luciferase reporter gene assay | ChEMBL. | 24702856 |
IC50 (binding) | = 0.69 uM | Inverse agonist activity at human ROR-gamma1 expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay | ChEMBL. | 24702856 |
IC50 (binding) | > 3 uM | Antagonist activity at human LXR-alpha expressed in HEK293 cells assessed as inhibition of T0901317-induced effect after 16 hrs by luciferase reporter gene assay | ChEMBL. | 24702856 |
IC50 (binding) | = 4.9 uM | Inverse agonist activity at human ROR-beta expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay | ChEMBL. | 24702856 |
IC50 (binding) | = 5.6 uM | Inverse agonist activity at human ROR-alpha1 expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay | ChEMBL. | 24702856 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.