Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Lactobacillus casei | Thymidylate synthase | Starlite/ChEMBL | References |
Lactobacillus casei | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium yoelii | thymidylate synthase, putative | Dihydrofolate reductase | 163 aa | 139 aa | 21.6 % |
Babesia bovis | dihydrofolate reductase/thymidilate synthase | Dihydrofolate reductase | 163 aa | 133 aa | 27.1 % |
Onchocerca volvulus | Putative dihydrofolate reductase | Dihydrofolate reductase | 163 aa | 173 aa | 27.2 % |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Dihydrofolate reductase | 163 aa | 138 aa | 29.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0274 | 1 | 0.5 |
Onchocerca volvulus | 0.0195 | 0 | 0.5 | |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 0.163 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 0.163 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0274 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 0.163 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0274 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0208 | 0.163 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0274 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 0.163 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 0.163 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 0.163 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0274 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 0.163 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 0.163 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0208 | 0.163 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14 10'-8M | Inhibition of MTX-resistant Lactobacillus casei dihydrofolate reductase | ChEMBL. | 409842 |
IC50 (binding) | = 4 uM | Inhibition of MTX-resistant Lactobacillus casei thymidylate synthetase | ChEMBL. | 409842 |
ID50 (functional) | = 0.23 ug ml-1 | Cytotoxicity against human CCRF-CEM cells | ChEMBL. | 409842 |
ILS (functional) | = 27 % | Antitumor activity against mouse L1210 cells allografted in BDF/1 hybrid mouse assessed as increase in life span relative to control | ChEMBL. | 409842 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.