Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0106 | 0.5625 | 0.5 | |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0119 | 0.6959 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0149 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0149 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0106 | 0.5625 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0106 | 0.5625 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0106 | 0.5625 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0106 | 0.5625 | 0.5864 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0119 | 0.6959 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0149 | 1 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0119 | 0.6959 | 1 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0119 | 0.6959 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0149 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0106 | 0.5625 | 0.5 |
Echinococcus granulosus | caspase | 0.0119 | 0.6959 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | caspase | 0.0119 | 0.6959 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0106 | 0.5625 | 0.5864 |
Brugia malayi | thymidylate synthase | 0.0106 | 0.5625 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0149 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.