Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0144 | 0.1746 | 0.1714 |
Echinococcus multilocularis | protein jagged 2 | 0.0043 | 0.0068 | 0.0276 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0248 | 0.3469 | 0.3451 |
Echinococcus multilocularis | slit 2 protein | 0.0043 | 0.0068 | 0.0276 |
Brugia malayi | glutaminase DH11.1 | 0.0276 | 0.3928 | 0.8345 |
Echinococcus multilocularis | neural cadherin | 0.0043 | 0.0068 | 0.0276 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.0276 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0144 | 0.1746 | 0.2814 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0248 | 0.3469 | 0.6211 |
Brugia malayi | Kringle domain containing protein | 0.0129 | 0.1487 | 0.3068 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0084 | 0.075 | 0.1476 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0043 | 0.0068 | 0.0276 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 0.9416 |
Echinococcus granulosus | neural cadherin | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0129 | 0.1487 | 0.6077 |
Echinococcus granulosus | delta-like protein 1 | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | laminin | 0.0112 | 0.1211 | 0.6463 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0068 | 0.036 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.0276 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0112 | 0.1211 | 0.4951 |
Echinococcus granulosus | fibropellin Ia | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0112 | 0.1211 | 0.2626 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.1898 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0187 | 0.2447 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.2447 | 0.6164 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0112 | 0.1211 | 0.806 |
Leishmania major | hypothetical protein, conserved | 0.0129 | 0.1487 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.2477 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0068 | 0.000000047947 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 0.2895 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.2447 | 0.6164 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0129 | 0.1487 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0644 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.075 | 0.1568 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0068 | 0.0276 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0067 | 0.0464 | 0.1237 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.0464 | 0.1028 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.0464 | 0.0911 |
Onchocerca volvulus | 0.0084 | 0.075 | 0.2101 | |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.032 | 0.1707 |
Echinococcus granulosus | Tolloid protein 1 | 0.0112 | 0.1211 | 0.6463 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0084 | 0.075 | 0.4003 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0054 | 0.0255 | 0.0431 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0295 | 0.4243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1487 | 0.3258 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0119 | 0.1332 | 0.3275 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0644 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.036 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0112 | 0.1211 | 0.806 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0048 | 0.0195 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0248 | 0.3469 | 0.4857 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.1875 | 0.4681 |
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0068 | 0.036 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1211 | 0.2626 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.032 | 0.0275 |
Loa Loa (eye worm) | glutaminase 2 | 0.0276 | 0.3928 | 0.8862 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.0464 | 0.2895 |
Echinococcus granulosus | slit 2 protein | 0.0043 | 0.0068 | 0.036 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.0739 | 0.1739 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0112 | 0.1211 | 0.2473 |
Echinococcus multilocularis | notch | 0.0043 | 0.0068 | 0.0276 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0129 | 0.1487 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.1875 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.3318 | 0.5995 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0372 | 0.5503 | 0.5502 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0043 | 0.0068 | 0.000000064246 |
Echinococcus granulosus | notch | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0129 | 0.1487 | 0.3258 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0084 | 0.075 | 0.3067 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.2838 | 0.5989 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.036 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0112 | 0.1211 | 0.2626 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0144 | 0.1746 | 0.0502 |
Echinococcus multilocularis | fibrillin 1 | 0.0112 | 0.1211 | 0.4951 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.1487 | 0.3677 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus multilocularis | fibropellin Ia | 0.0043 | 0.0068 | 0.0276 |
Schistosoma mansoni | glutaminase | 0.0276 | 0.3928 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0119 | 0.1332 | 0.5443 |
Schistosoma mansoni | egf-like domain protein | 0.0112 | 0.1211 | 0.2964 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.1875 | 0.7661 |
Onchocerca volvulus | Arrow homolog | 0.0112 | 0.1211 | 0.3519 |
Toxoplasma gondii | kringle domain-containing protein | 0.0129 | 0.1487 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.023 | 0.3165 | 0.409 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0048 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.4391 | 0.9926 |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0068 | 0.000000045149 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0123 | 0.1396 | 0.2122 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0043 | 0.0068 | 0.000000064246 |
Brugia malayi | notch-like transmembrane receptor | 0.0043 | 0.0068 | 0.000000045149 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.4423 | 0.9416 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0323 | 0.4693 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0112 | 0.1211 | 0.2473 |
Loa Loa (eye worm) | glutaminase | 0.0276 | 0.3928 | 0.8862 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0641 | 0.9962 | 0.9933 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0365 | 0.539 | 0.5388 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0129 | 0.1487 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0276 | 0.3928 | 0.7113 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0112 | 0.1211 | 0.2964 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0372 | 0.5503 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.2838 | 0.636 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0132 | 0.1548 | 0.1513 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0043 | 0.0068 | 0.0276 |
Brugia malayi | Protein kinase domain containing protein | 0.0129 | 0.1487 | 0.3068 |
Onchocerca volvulus | 0.0239 | 0.3318 | 1 | |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0132 | 0.1548 | 0.2422 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0119 | 0.1332 | 0.7104 |
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0068 | 0.036 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Mycobacterium ulcerans | glutaminase | 0.0276 | 0.3928 | 0.3914 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.032 | 0.0546 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0058 | 0.032 | 0.0654 |
Onchocerca volvulus | 0.0129 | 0.1487 | 0.4366 | |
Echinococcus granulosus | neurogenic locus protein delta | 0.0043 | 0.0068 | 0.036 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.0276 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.023 | 0.3165 | 0.5612 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0068 | 0.0276 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0112 | 0.1211 | 0.2473 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Echinococcus multilocularis | laminin | 0.0112 | 0.1211 | 0.4951 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0067 | 0.0464 | 0.0858 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0129 | 0.1487 | 0.7932 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0365 | 0.539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1211 | 0.2626 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.032 | 0.0275 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0084 | 0.075 | 0.1769 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4243 | 0.7691 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.032 | 0.1308 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0068 | 0.0276 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0043 | 0.0068 | 0.036 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0365 | 0.539 | 0.9714 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0372 | 0.5503 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0372 | 0.5503 | 0.2188 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0641 | 0.9962 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.