Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0151 | 0.1688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1879 | 0.1879 |
Echinococcus multilocularis | protein kinase c iota type | 0.0119 | 0.1017 | 0.1288 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.0151 | 0.1688 | 0.5 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0151 | 0.1688 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.0294 | 0.4634 | 0.4634 |
Trypanosoma brucei | lanosterol synthase | 0.0166 | 0.1991 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0451 | 0.7898 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0313 | 0.5024 | 0.6362 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0244 | 0.3617 | 0.3617 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0166 | 0.1991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.4429 | 0.4429 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0235 | 0.3412 | 0.432 |
Onchocerca volvulus | 0.016 | 0.1879 | 0.5 | |
Schistosoma mansoni | atypical protein kinase C | 0.0119 | 0.1017 | 0.1684 |
Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.0151 | 0.1688 | 1 |
Brugia malayi | hypothetical protein | 0.0093 | 0.0476 | 0.0476 |
Echinococcus multilocularis | integrin beta 2 | 0.0451 | 0.7898 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0119 | 0.1017 | 0.1288 |
Echinococcus granulosus | protein kinase C gamma type | 0.0313 | 0.5024 | 0.6362 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0362 | 0.6042 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0362 | 0.6042 | 0.765 |
Schistosoma mansoni | integrin beta subunit | 0.0359 | 0.5983 | 0.9902 |
Giardia lamblia | Prenyltransferase | 0.0151 | 0.1688 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0362 | 0.6042 | 1 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0151 | 0.1688 | 0.1688 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.2897 | 0.2897 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.012 | 0.1052 | 0.1332 |
Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.0151 | 0.1688 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0362 | 0.6042 | 0.765 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0151 | 0.1688 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0178 | 0.2243 | 0.2243 |
Schistosoma mansoni | integrin alpha-4 | 0.0263 | 0.4009 | 0.6635 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0178 | 0.2243 | 0.284 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0151 | 0.1688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1879 | 0.1879 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1879 | 0.1879 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0151 | 0.1688 | 1 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.0151 | 0.1688 | 0.2137 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0476 | 0.0476 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.0151 | 0.1688 | 0.8474 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.0151 | 0.1688 | 0.2137 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0166 | 0.1991 | 1 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0151 | 0.1688 | 0.1688 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0178 | 0.2243 | 0.284 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0151 | 0.1688 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0553 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.3412 | 0.3412 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0235 | 0.3412 | 0.432 |
Brugia malayi | protein kinase C II. | 0.0178 | 0.2243 | 0.2243 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.0151 | 0.1688 | 0.2793 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.3318 | 0.3318 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0178 | 0.2243 | 0.3712 |
Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.0151 | 0.1688 | 1 |
Leishmania major | farnesyltransferase beta subunit | 0.0151 | 0.1688 | 1 |
Brugia malayi | Kelch motif family protein | 0.0093 | 0.0476 | 0.0476 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0235 | 0.3412 | 0.432 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0166 | 0.1991 | 0.5 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0093 | 0.0476 | 0.0476 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.