Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.01 umol/ml | Antimicrobial activity against Escherichia coli after 24 hrs by broth dilution assay | ChEMBL. | 833811 |
MIC (functional) | > 0.4 umol/ml | Antimicrobial activity against Candida albicans after 48 hrs by broth dilution assay | ChEMBL. | 833811 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.