Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutaminase 2 | 0.0298 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.0444 | 0.0666 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1475 | 0.1475 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0091 | 0.0091 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0581 | 0.0581 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0124 | 0.0124 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0091 | 0.0091 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0598 | 0.0598 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0091 | 0.0091 |
Onchocerca volvulus | 0.0026 | 0.0598 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 0.6663 | 0.6663 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0908 | 0.0908 |
Loa Loa (eye worm) | glutaminase | 0.0298 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0444 | 0.0444 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.1535 | 0.1535 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.1535 | 0.2303 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0091 | 0.0137 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0091 | 0.0137 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0249 | 0.0249 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.0091 | 0.0091 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0091 | 0.0091 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.0444 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0202 | 0.6663 | 0.6663 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 0.6663 | 0.6663 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0598 | 0.0598 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.0444 | 0.0666 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0444 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.0091 | 0.0091 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0444 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.0091 | 0.0091 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.0091 | 0.0091 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0598 | 0.0897 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.0444 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.0091 | 0.0137 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.0091 | 0.0091 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.1535 | 0.2303 |
Mycobacterium ulcerans | glutaminase | 0.0298 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | TAR-binding protein | 0.0202 | 0.6663 | 0.6663 |
Brugia malayi | MH2 domain containing protein | 0.0135 | 0.4347 | 0.4347 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0091 | 0.0137 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0091 | 0.0137 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0091 | 0.0091 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.0091 | 0.0091 |
Echinococcus granulosus | lamin | 0.0026 | 0.0598 | 0.0897 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 0.6663 | 0.6663 |
Schistosoma mansoni | lamin | 0.0026 | 0.0598 | 0.0598 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0124 | 0.0186 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0598 | 0.0897 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0107 | 0.0107 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0249 | 0.0249 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.1535 | 0.1535 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.0091 | 0.0091 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0091 | 0.0137 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.0091 | 0.0091 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0249 | 0.0374 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0135 | 0.4347 | 0.4347 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0091 | 0.0091 |
Brugia malayi | TAR-binding protein | 0.0202 | 0.6663 | 0.6663 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | RNA binding protein | 0.0202 | 0.6663 | 0.6663 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0444 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0444 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.0091 | 0.0091 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0598 | 0.0897 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0091 | 0.0091 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0091 | 0.0091 |
Trichomonas vaginalis | glutaminase, putative | 0.0298 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0202 | 0.6663 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0598 | 0.0598 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0091 | 0.0091 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0444 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0249 | 0.0249 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0598 | 0.0598 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0091 | 0.0091 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 0.6663 | 0.6663 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.0091 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1475 | 0.1475 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0091 | 0.0091 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0444 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 0.0598 | 0.0598 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0598 | 0.0598 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0249 | 0.0374 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.1535 | 0.2303 |
Schistosoma mansoni | tar DNA-binding protein | 0.0202 | 0.6663 | 0.6663 |
Schistosoma mansoni | glutaminase | 0.0298 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.0091 | 0.0091 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0091 | 0.0137 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.0091 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0091 | 0.0091 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0173 | 0.0173 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.0091 | 0.0091 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0908 | 0.0908 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0173 | 0.0173 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0598 | 0.0897 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.0091 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0091 | 0.0091 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0091 | 0.0137 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0091 | 0.0091 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0249 | 0.0374 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1475 | 0.1475 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.0091 | 0.0091 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.0091 | 0.0137 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0249 | 0.0249 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0091 | 0.0091 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.1535 | 0.2303 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0124 | 0.0186 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0202 | 0.6663 | 0.6663 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0249 | 0.0374 |
Onchocerca volvulus | 0.0026 | 0.0598 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0249 | 0.0249 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0091 | 0.0091 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.0091 | 0.0091 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0091 | 0.0091 |
Brugia malayi | RNA binding protein | 0.0202 | 0.6663 | 0.6663 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.0091 | 0.0091 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0091 | 0.0137 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0135 | 0.4347 | 0.4347 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1475 | 0.1475 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.0091 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0091 | 0.0091 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0444 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.0091 | 0.0137 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0091 | 0.0137 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0444 | 0.5 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0598 | 0.0897 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0091 | 0.0091 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0444 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0107 | 0.0107 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0249 | 0.0374 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0249 | 0.0374 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0444 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0091 | 0.0091 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.0091 | 0.0091 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0249 | 0.0249 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0091 | 0.0137 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0444 | 0.0444 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0249 | 0.0249 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0444 | 0.0444 |
Echinococcus multilocularis | tar DNA binding protein | 0.0202 | 0.6663 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.0444 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0598 | 0.0598 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0908 | 0.0908 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.0091 | 0.0137 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0091 | 0.0091 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0091 | 0.0091 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.