Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0035 | 0.437 | 0.437 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.36 | 0.36 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.36 | 0.36 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.437 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.437 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.437 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.437 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.437 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.437 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.437 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 351 uM | Binding affinity to N-terminal His-tagged C-terminal Avi-tagged MAP4K4 (unknown origin) expressed in baculovirus expression system by surface plasmon resonance analysis | ChEMBL. | 24673130 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.