Detailed information for compound 1910665

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 185.225 | Formula: C11H11N3
  • H donors: 2 H acceptors: 1 LogP: 1.45 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1cccc(c1)c1cccnc1N
  • InChi: 1S/C11H11N3/c12-9-4-1-3-8(7-9)10-5-2-6-14-11(10)13/h1-7H,12H2,(H2,13,14)
  • InChiKey: LBEKKGYQZRAUOI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0536 0.1029
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0086 0.0206
Onchocerca volvulus 0.0055 0.0496 0.1007
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.002 0.0065 0.0195
Echinococcus multilocularis carboxylesterase 5A 0.0327 0.3845 0.3837
Brugia malayi Carboxylesterase family protein 0.0327 0.3845 1
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0171 0.3111
Leishmania major cytochrome p450-like protein 0.002 0.0065 0.1221
Loa Loa (eye worm) hypothetical protein 0.0055 0.0496 0.126
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.002 0.0065 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0536 0.146
Loa Loa (eye worm) hypothetical protein 0.0052 0.0451 0.1145
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0242
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0451 0.0439
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0267 0.0587
Echinococcus multilocularis para nitrobenzyl esterase 0.0055 0.0496 0.0483
Loa Loa (eye worm) acetylcholinesterase 1 0.0327 0.3845 1
Echinococcus granulosus BC026374 protein S09 family 0.0055 0.0496 0.095
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0055 0.0496 0.1329
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0125
Mycobacterium ulcerans beta-lactamase 0.0037 0.0267 0.4681
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0267 0.0943
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0441 0.1117
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0266 0.0499
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0267 0.0678
Trypanosoma brucei cytochrome P450, putative 0.0051 0.0439 0.8164
Schistosoma mansoni acetylcholinesterase 0.0055 0.0496 0.1274
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0065 0.1221
Echinococcus granulosus expressed protein 0.0429 0.5098 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0496 0.126
Mycobacterium tuberculosis Carboxylesterase LipT 0.0055 0.0496 0.1793
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0092 0.0223
Brugia malayi Pax transcription factor protein 2 0.0245 0.2838 0.7371
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0267 0.0943
Schistosoma mansoni hypothetical protein 0.002 0.0065 0.0153
Loa Loa (eye worm) hypothetical protein 0.0327 0.3845 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0267 0.4979
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.276 0.717
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0029 0.0032
Echinococcus multilocularis protein patched 0.0043 0.0345 0.0333
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0267 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0267 0.4916
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0267 1
Echinococcus granulosus acetylcholinesterase 0.0327 0.3845 0.7536
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0086 0.0191
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0036 0.0062
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0461
Brugia malayi beta-lactamase family protein 0.0037 0.0267 0.0663
Mycobacterium tuberculosis Conserved protein 0.0037 0.0267 0.0943
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0536 0.1365
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0267 0.0254
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0266 0.0677
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.002 0.0065 0.0195
Onchocerca volvulus 0.0272 0.3167 1
Schistosoma mansoni survival motor neuron protein 0.0055 0.0497 0.1278
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0266 0.0254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0451 0.1158
Schistosoma mansoni hypothetical protein 0.0042 0.0326 0.0832
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0055 0.0496 0.1274
Loa Loa (eye worm) cytochrome P450 0.002 0.0065 0.0138
Brugia malayi hypothetical protein 0.0055 0.0496 0.126
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0536 1
Schistosoma mansoni hypothetical protein 0.0042 0.0326 0.0832
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0086 0.0206
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0086 0.0206
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0345 0.0868
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.002 0.0065 0.0195
Trypanosoma cruzi ISWI complex protein 0.0016 0.0007 0.0125
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0222 0.0411
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0016
Loa Loa (eye worm) hypoxia-induced factor 1 0.0173 0.1946 0.5044
Schistosoma mansoni hypothetical protein 0.0042 0.0326 0.0832
Schistosoma mansoni hypothetical protein 0.0055 0.0497 0.1278
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0266 0.0498
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0242
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0086 0.0073
Echinococcus multilocularis lamin 0.0031 0.0196 0.0184
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0086 0.0144
Loa Loa (eye worm) hypothetical protein 0.0043 0.035 0.0881
Brugia malayi PHD-finger family protein 0.0025 0.0127 0.0299
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0267 0.0943
Echinococcus granulosus lamin 0.0031 0.0196 0.0361
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.002 0.0065 0.0195
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0013 0.0242
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0065 0.0104
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0074 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0237 0.06
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0237 0.06
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0086 0.0206
Trichomonas vaginalis spcc417.12 protein, putative 0.0055 0.0496 0.1329
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1051 0.2042
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0092 0.0208
Echinococcus multilocularis acetylcholinesterase 0.0327 0.3845 0.3837
Mycobacterium ulcerans hypothetical protein 0.0037 0.0267 0.4681
Loa Loa (eye worm) hypothetical protein 0.0055 0.0496 0.126
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0267 0.4681
Brugia malayi beta-lactamase family protein 0.0037 0.0267 0.0663
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0267 0.0587
Loa Loa (eye worm) hypothetical protein 0.0039 0.0296 0.0741
Schistosoma mansoni intermediate filament proteins 0.0031 0.0196 0.0494
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.107 0.2771
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0055 0.0496 0.1274
Brugia malayi hypothetical protein 0.0037 0.0266 0.0662
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0267 0.0587
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0055 0.0496 0.1274
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0439 0.1112
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.002 0.0065 0.0195
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0055 0.0496 0.1793
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0013 0.0001
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0055 0.0496 0.0483
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0267 0.0663
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.002 0.0065 0.0195
Brugia malayi beta-lactamase 0.0037 0.0267 0.0663
Schistosoma mansoni lamin 0.0031 0.0196 0.0494
Loa Loa (eye worm) hypothetical protein 0.003 0.0188 0.0457
Brugia malayi Pre-SET motif family protein 0.0239 0.276 0.717
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0536 0.146
Brugia malayi Carboxylesterase family protein 0.0055 0.0496 0.126
Onchocerca volvulus 0.0037 0.0267 0.0237
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.2704 1
Echinococcus granulosus expressed conserved protein 0.0094 0.0976 0.1895
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.1582 0.1571
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0451 0.0863
Trichomonas vaginalis esterase, putative 0.0037 0.0267 0.0587
Loa Loa (eye worm) hypothetical protein 0.0055 0.0496 0.126
Onchocerca volvulus 0.0041 0.0324 0.0431
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0065 0.1004
Echinococcus multilocularis protein dispatched 1 0.0049 0.042 0.0408
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0171 0.3197
Loa Loa (eye worm) hypothetical protein 0.0272 0.3162 0.8217
Onchocerca volvulus 0.0055 0.0496 0.1007
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.0439 0.8187
Schistosoma mansoni aryl hydrocarbon receptor 0.0056 0.0503 0.1293
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0016
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1051 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0267 0.0663
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0098 0.0237
Echinococcus multilocularis transfer RNA-Lys 0.0041 0.0324 0.0312
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0536 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0441 0.1117
Onchocerca volvulus 0.0154 0.1713 0.5103
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0345 0.0842
Echinococcus granulosus carboxylesterase 5A 0.0327 0.3845 0.7536
Entamoeba histolytica hypothetical protein 0.0037 0.0266 0.1871
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0345 0.0333
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0065 0.111
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0086 0.0206
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.002 0.0065 0.0195
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0536 1
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0086 0.0206
Brugia malayi hypothetical protein 0.0154 0.1713 0.4436
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.0191
Loa Loa (eye worm) hypothetical protein 0.0053 0.0465 0.1179
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0013 0.0016
Loa Loa (eye worm) carboxylesterase 0.0327 0.3845 1
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0536 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0326 0.0818
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0267 0.0943
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0345 0.0654
Entamoeba histolytica hypothetical protein 0.0037 0.0266 0.1871
Schistosoma mansoni hypothetical protein 0.0035 0.0243 0.0615
Leishmania major hypothetical protein, conserved 0.0029 0.0171 0.3197
Brugia malayi isocitrate dehydrogenase 0.0016 0.0013 0.0001
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.002 0.0065 0.0195
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0092 0.0208
Echinococcus multilocularis lamin dm0 0.0031 0.0196 0.0184
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0086 0.0073
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0119
Brugia malayi PXA domain containing protein 0.0022 0.0086 0.0191
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0065 0.1221
Brugia malayi Cytochrome P450 family protein 0.0051 0.0439 0.1112
Loa Loa (eye worm) hypothetical protein 0.0037 0.0267 0.0663
Onchocerca volvulus 0.0245 0.2838 0.889
Loa Loa (eye worm) hypothetical protein 0.0072 0.0703 0.1801
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0086 0.0144
Echinococcus multilocularis neuroligin 0.0055 0.0496 0.0483
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1051 0.104
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1314 0.3396
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0497 0.1264
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0086 0.0206
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0055 0.0496 0.095
Mycobacterium ulcerans carboxylesterase, LipT 0.0055 0.0496 1
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0086 0.0191
Echinococcus granulosus lamin dm0 0.0031 0.0196 0.0361
Loa Loa (eye worm) CYP4Cod1 0.0051 0.0439 0.1112
Entamoeba histolytica hypothetical protein 0.0037 0.0266 0.1871
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0451 0.1158
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0086 0.0191
Mycobacterium leprae Probable lipase LipE 0.0037 0.0267 1
Echinococcus multilocularis survival motor neuron protein 1 0.0272 0.3162 0.3153
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.002 0.0065 0.0195
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.002 0.0065 0.0195
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0086 0.0191
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0086 0.0073
Loa Loa (eye worm) hypothetical protein 0.0154 0.1713 0.4436
Echinococcus granulosus single minded 2 0.0041 0.0324 0.0613
Schistosoma mansoni gliotactin 0.0055 0.0496 0.1274
Brugia malayi hypothetical protein 0.0019 0.0045 0.0084
Leishmania major hypothetical protein, conserved 0.0037 0.0267 0.4979
Loa Loa (eye worm) hypothetical protein 0.0037 0.0267 0.0663
Echinococcus multilocularis zinc finger protein 0.002 0.006 0.0048
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.0439 0.8187
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0086 0.0191
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.06
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0086 0.0206
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.002 0.0065 0.0195
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0564 0.1085
Brugia malayi Carboxylesterase family protein 0.0055 0.0496 0.126
Plasmodium vivax SET domain protein, putative 0.0034 0.0237 0.883
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0086 0.0144
Brugia malayi hypothetical protein 0.0029 0.0171 0.0414
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0092 0.0223
Echinococcus multilocularis expressed protein 0.0429 0.5098 0.5092
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0086 0.0206
Onchocerca volvulus 0.0055 0.0497 0.1013
Brugia malayi hypothetical protein 0.0272 0.3162 0.8217
Mycobacterium ulcerans putative regulatory protein 0.0041 0.0324 0.6015
Onchocerca volvulus 0.0034 0.0237 0.0137
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0267 0.0663
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0196 0.0479
Brugia malayi MAP kinase sur-1 0.0059 0.0536 0.1365
Entamoeba histolytica hypothetical protein 0.0037 0.0266 0.1871
Loa Loa (eye worm) carboxylesterase 0.0055 0.0496 0.126
Brugia malayi Cytochrome P450 family protein 0.0051 0.0439 0.1112
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0092 0.0223
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0267 0.4979
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.0191
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0055 0.0496 0.1793
Brugia malayi MH2 domain containing protein 0.0122 0.1314 0.3396
Schistosoma mansoni patched 1 0.0043 0.0345 0.0882
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0267 0.0587
Brugia malayi hypothetical protein 0.0022 0.0086 0.0191
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0016
Echinococcus granulosus zinc finger protein 0.002 0.006 0.0094
Loa Loa (eye worm) hypothetical protein 0.0187 0.2125 0.5511
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0267 0.0943
Loa Loa (eye worm) hypothetical protein 0.0037 0.0267 0.0663
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0564 0.0552
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0243 0.06
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.002 0.0065 0.0195
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0086 0.0144
Echinococcus multilocularis musashi 0.0031 0.0196 0.0184
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0086 0.0191
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0098 0.0167
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0086 0.0144
Echinococcus multilocularis geminin 0.0173 0.1943 0.1933
Leishmania major cytochrome p450-like protein 0.002 0.0065 0.1221
Loa Loa (eye worm) hypothetical protein 0.0055 0.0496 0.126
Brugia malayi cytochrome P450 0.002 0.0065 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0536 0.1378
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0536 0.0524
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1051 0.271
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0092 0.0208
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0536 0.0524
Echinococcus multilocularis 0.002 0.0065 0.0053
Brugia malayi PAS domain containing protein 0.0056 0.0503 0.128
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0267 0.0663
Echinococcus granulosus survival motor neuron protein 1 0.0272 0.3162 0.6192
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.002 0.0065 0.0195
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0441 0.1117
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0086 0.0073
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0267 0.4681
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0065 0.1221
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0266 0.0254
Brugia malayi hypothetical protein 0.0022 0.0086 0.0191
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0086 0.0144
Brugia malayi Pre-SET motif family protein 0.0034 0.0237 0.0586
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.0191
Brugia malayi PXA domain containing protein 0.0022 0.0086 0.0191
Schistosoma mansoni hypothetical protein 0.0173 0.1943 0.5045
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0536 0.146
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0051 0.0439 0.8677
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0019 0.0017
Schistosoma mansoni single-minded 0.0056 0.0503 0.1293
Brugia malayi Bromodomain containing protein 0.0039 0.0296 0.0738
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.002 0.0065 0.0195
Brugia malayi Carboxylesterase family protein 0.0327 0.3845 1
Brugia malayi Bromodomain containing protein 0.0076 0.0757 0.1941
Loa Loa (eye worm) hypothetical protein 0.0055 0.0496 0.126
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0267 0.0943
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0029 0.0057
Brugia malayi Carboxylesterase family protein 0.0055 0.0496 0.126
Brugia malayi Cytochrome P450 family protein 0.002 0.0065 0.0138
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.002 0.0065 0.0195
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0196 0.0479
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.0191
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0237 0.0225
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0029 0.0057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0171 0.0414
Brugia malayi Carboxylesterase family protein 0.0055 0.0496 0.126
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0086 0.0144
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.1582 0.3086
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0267 0.0678
Leishmania major cytochrome p450-like protein 0.0051 0.0439 0.8187
Schistosoma mansoni neuroligin 3 (S09 family) 0.0055 0.0496 0.1274
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0086 0.0073
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1314 0.3396
Schistosoma mansoni lamin 0.0031 0.0196 0.0494
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0086 0.0073
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0092 0.008
Echinococcus granulosus intermediate filament protein 0.0031 0.0196 0.0361
Schistosoma mansoni hypothetical protein 0.0042 0.0326 0.0832
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.002 0.0065 0.0195
Loa Loa (eye worm) hypothetical protein 0.0327 0.3845 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.002 0.0065 0.0195
Schistosoma mansoni hypothetical protein 0.0037 0.0266 0.0677
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0439 0.1112
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0171 0.6239
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0171 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0536 1
Echinococcus granulosus para nitrobenzyl esterase 0.0055 0.0496 0.095
Echinococcus granulosus geminin 0.0173 0.1943 0.3796
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0086 0.0191
Toxoplasma gondii ABC1 family protein 0.0037 0.0267 0.4854
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0055 0.0496 0.126
Echinococcus multilocularis acetylcholinesterase 0.0327 0.3845 0.3837
Loa Loa (eye worm) hypothetical protein 0.0031 0.0196 0.0479
Trichomonas vaginalis set domain proteins, putative 0.0272 0.3167 1
Schistosoma mansoni hypothetical protein 0.0173 0.1943 0.5045
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0237 0.4286
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0086 0.0191
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0013 0.0001
Schistosoma mansoni BC026374 protein (S09 family) 0.0055 0.0496 0.1274
Mycobacterium tuberculosis Conserved protein 0.0037 0.0267 0.0943
Schistosoma mansoni cytochrome P450 0.002 0.0065 0.0153
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0065 0.1221
Onchocerca volvulus 0.0037 0.0267 0.0237
Schistosoma mansoni bromodomain containing protein 0.0065 0.0609 0.157
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0098 0.0085
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0086 0.0206
Brugia malayi intermediate filament protein 0.0031 0.0196 0.0479
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0086 0.0206
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0029 0.0016
Loa Loa (eye worm) hypothetical protein 0.01 0.1051 0.271
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.0191
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0196 0.0479
Echinococcus granulosus neuroligin 0.0055 0.0496 0.095
Brugia malayi bHLH-PAS transcription factor 0.0041 0.0324 0.0813
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0086 0.0073
Mycobacterium tuberculosis Conserved protein 0.0037 0.0267 0.0943
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0536 0.1029
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0086 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0536 0.146
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.002 0.0065 0.0195
Mycobacterium ulcerans lipase LipD 0.0037 0.0267 0.4681
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0536 1
Onchocerca volvulus 0.0037 0.0267 0.0237
Brugia malayi hypoxia-induced factor 1 0.0173 0.1946 0.5044
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.002 0.0065 0.0195
Loa Loa (eye worm) pax transcription factor protein 2 0.0245 0.2838 0.7371
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0267 0.0663
Schistosoma mansoni hypothetical protein 0.0021 0.0074 0.0175
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0327 0.3845 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0019 0.0017
Brugia malayi CHE-14 protein 0.0043 0.0345 0.0868
Schistosoma mansoni zinc finger protein 0.002 0.006 0.014
Echinococcus granulosus acetylcholinesterase 0.0327 0.3845 0.7536
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0171 0.3197
Loa Loa (eye worm) carboxylesterase 0.0055 0.0496 0.126
Trypanosoma cruzi ISWI complex protein 0.0016 0.0007 0.0125
Echinococcus multilocularis expressed conserved protein 0.0094 0.0976 0.0965
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0345 0.0654
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.0191
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0092 0.0157
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0267 0.0943
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0171 0.3029
Onchocerca volvulus 0.0055 0.0496 0.1007
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0267 0.0587
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0086 0.0073
Loa Loa (eye worm) hypothetical protein 0.0037 0.0267 0.0663
Onchocerca volvulus 0.0055 0.0496 0.1007
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0536 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0267 0.05
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0065 0.0138
Brugia malayi Cytochrome P450 family protein 0.002 0.0065 0.0138
Loa Loa (eye worm) hypothetical protein 0.0051 0.0441 0.1117
Echinococcus multilocularis BC026374 protein (S09 family) 0.0055 0.0496 0.0483
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0086 0.0073
Brugia malayi hypothetical protein 0.0187 0.2125 0.5511
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0171 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0345 0.0868
Trypanosoma brucei protein kinase, putative 0.0059 0.0536 1
Onchocerca volvulus 0.0055 0.0496 0.1007

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 65 uM Binding affinity to N-terminal His-tagged C-terminal Avi-tagged MAP4K4 (unknown origin) expressed in baculovirus expression system by surface plasmon resonance analysis ChEMBL. 24673130

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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