Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Cholinesterase | 574 aa | 520 aa | 27.1 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Cholinesterase | 574 aa | 590 aa | 25.1 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Cholinesterase | 574 aa | 636 aa | 34.9 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 472 aa | 27.5 % |
Echinococcus multilocularis | neuroligin | Cholinesterase | 574 aa | 493 aa | 26.2 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Echinococcus granulosus | BC026374 protein S09 family | Cholinesterase | 574 aa | 642 aa | 34.4 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Onchocerca volvulus | Cholinesterase | 574 aa | 586 aa | 27.1 % | |
Loa Loa (eye worm) | hypothetical protein | Cholinesterase | 574 aa | 573 aa | 26.4 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Cholinesterase | 574 aa | 547 aa | 29.4 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 549 aa | 29.5 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Cholinesterase | 574 aa | 560 aa | 29.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12.83 uM | Inhibition of BuChE in equine serum using S-butyrylthiocholine iodide as substrate preincubated with enzyme for 6 mins followed by substrate addition by Ellman's method | ChEMBL. | 24726809 |
IC50 (binding) | = 15.9 uM | Inhibition of BuChE in human serum using S-butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition by Ellman's method | ChEMBL. | 24726809 |
IC50 (binding) | = 39.63 uM | Inhibition of AChE in human erythrocytes using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition by Ellman's method | ChEMBL. | 24726809 |
IC50 (binding) | = 41.75 uM | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 6 mins followed by substrate addition by Ellman's method | ChEMBL. | 24726809 |
Inhibition (binding) | = 62.7 % | Inhibition of amyloid beta (1 to 42) (unknown origin) self-aggregation at 20 uM after 46 to 48 hrs by thioflavin T based fluorometric assay | ChEMBL. | 24726809 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.