Detailed information for compound 1913827

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 215.23 | Formula: C7H9N3O3S
  • H donors: 1 H acceptors: 3 LogP: -0.77 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][n+]1ccccc1/C=N/NS(=O)(=O)C
  • InChi: 1S/C7H9N3O3S/c1-14(12,13)9-8-6-7-4-2-3-5-10(7)11/h2-6,9H,1H3/b8-6+
  • InChiKey: PHLXNFIAJBKMDE-SOFGYWHQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.0737 0.5855
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0166 0.0175
Loa Loa (eye worm) hypothetical protein 0.0007 0.0063 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.1668 0.2274
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.1668 0.2317
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0006 0.004 0.0321
Onchocerca volvulus 0.0034 0.1259 1
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.1259 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0006 0.004 0.0321
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.1259 0.1259
Mycobacterium ulcerans esterase/lipase LipP 0.0034 0.1259 1
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0554 0.4398
Mycobacterium ulcerans acyl-CoA synthetase 0.0006 0.004 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.0554 0.0554
Schistosoma mansoni hypothetical protein 0.0059 0.2389 0.3319
Brugia malayi MH1 domain containing protein 0.0016 0.0449 0.0449
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0449 0.0449
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0006 0.004 0.0321
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0488 0.7691
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0449 0.0571
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0737 0.0737
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0216 0.939 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0488 0.3875
Entamoeba histolytica deoxycytidyl transferase, putative 0.0018 0.0554 0.7367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0448 0.0477
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.1259 0.175
Loa Loa (eye worm) hypothetical protein 0.0017 0.0488 0.0488
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0166 0.1318
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Brugia malayi Latrophilin receptor protein 2 0.0059 0.2389 0.2389
Schistosoma mansoni hypothetical protein 0.0059 0.2389 0.3319
Schistosoma mansoni hypothetical protein 0.0167 0.7197 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Schistosoma mansoni smad 0.0016 0.0449 0.0624
Mycobacterium tuberculosis Conserved protein 0.0034 0.1259 0.1341
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0448 0.0477
Loa Loa (eye worm) hypothetical protein 0.0128 0.5451 0.5451
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.1259 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0431 0.3421
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0187 0.8089 0.8089
Mycobacterium tuberculosis Conserved protein 0.0034 0.1259 0.1341
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0166 0.0175
Schistosoma mansoni Smad4 0.0016 0.0449 0.0624
Trypanosoma brucei unspecified product 0.0018 0.0554 0.4398
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0022 0.0737 0.0785
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0757 0.5875
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0737 1
Leishmania major acetyl-CoA synthetase, putative 0.0006 0.004 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0545 0.0757
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.004 0.0043
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.1668 0.1668
Echinococcus multilocularis dna polymerase eta 0.0018 0.0554 0.0718
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0018 0.0554 0.4212
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0737 0.5855
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0059 0.2389 0.3282
Schistosoma mansoni smad1 5 8 and 0.0016 0.0449 0.0624
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0006 0.004 0.004
Echinococcus granulosus mothers against decapentaplegic 2 0.0007 0.0063 0.0031
Brugia malayi MH1 domain containing protein 0.0009 0.0137 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0006 0.004 0.0321
Trichomonas vaginalis DNA polymerase eta, putative 0.0018 0.0554 0.4212
Mycobacterium ulcerans acyl-CoA synthetase 0.0006 0.004 0.0321
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0022 0.0737 0.5855
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0449 0.0571
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0006 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0006 0.004 0.004
Echinococcus multilocularis dna polymerase kappa 0.0018 0.0554 0.0718
Brugia malayi mothers against decapentaplegic homolog 3 0.0007 0.0063 0.0063
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0737 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0006 0.004 0.0321
Loa Loa (eye worm) transcription factor SMAD2 0.023 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0423 0.3357
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0006 0.004 0.004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0059 0.2389 0.3282
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0166 0.0175
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0006 0.004 0.0043
Echinococcus multilocularis GPCR, family 2 0.0059 0.2389 0.3282
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0449 0.0449
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0006 0.004 0.0043
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0449 0.0571
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0737 0.5855
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.1668 0.2274
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0449 0.0571
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0006 0.004 0.0321
Entamoeba histolytica acyl-coA synthetase, putative 0.0022 0.0737 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0488 0.0488
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.1259 0.1341
Loa Loa (eye worm) hypothetical protein 0.0006 0.004 0.004
Mycobacterium ulcerans lipase LipD 0.0034 0.1259 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0488 0.3875
Schistosoma mansoni hypothetical protein 0.0059 0.2389 0.3319
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0006 0.004 0.0321
Loa Loa (eye worm) hypothetical protein 0.0009 0.0166 0.0166
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.1259 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0305 0.2419
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.004 0.0043
Loa Loa (eye worm) hypothetical protein 0.0034 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.0022 0.0737 0.0737
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.004 0.0043
Leishmania major hypothetical protein, conserved 0.0034 0.1259 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0554 0.059
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0288 0.2288
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.1259 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.1259 0.1341
Echinococcus multilocularis geminin 0.0167 0.7197 1
Echinococcus granulosus Smad4 0.0016 0.0449 0.0571
Trichomonas vaginalis esterase, putative 0.0034 0.1259 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0006 0.004 0.0321
Loa Loa (eye worm) latrophilin receptor protein 2 0.0059 0.2389 0.2389
Brugia malayi Calcitonin receptor-like protein seb-1 0.0187 0.8089 0.8089
Trypanosoma brucei unspecified product 0.0012 0.0305 0.2419
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0006 0.004 0.0321
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.1259 0.1703
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0018 0.0554 0.4398
Schistosoma mansoni Smad4 0.0007 0.0063 0.0087
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0018 0.0554 0.059
Giardia lamblia DINP protein human, muc B family 0.0018 0.0554 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0737 0.5718
Loa Loa (eye worm) Smad1 0.0016 0.0449 0.0449
Loa Loa (eye worm) hypothetical protein 0.0113 0.4814 0.4814
Loa Loa (eye worm) hypothetical protein 0.0017 0.0488 0.0488
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0288 0.2288
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0757 0.5875
Mycobacterium ulcerans acyl-CoA synthetase 0.0006 0.004 0.0321
Brugia malayi Smad1 0.0016 0.0449 0.0449
Loa Loa (eye worm) hypothetical protein 0.0034 0.1259 0.1259
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Schistosoma mansoni acetyl-CoA synthetase 0.0006 0.004 0.0056
Trypanosoma cruzi DNA polymerase eta, putative 0.0018 0.0554 0.4398
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0006 0.004 0.0321
Loa Loa (eye worm) hypothetical protein 0.0017 0.0488 0.0488
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.1259 0.1341
Plasmodium vivax hypothetical protein, conserved 0.0034 0.1259 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0006 0.004 0.0043
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0554 0.4398
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.1668 0.2274
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0166 0.0166
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0737 0.0785
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0006 0.004 0.0321
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0737 0.5855
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.1259 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Echinococcus multilocularis Smad4 0.0016 0.0449 0.0571
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.004 0.004
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0006 0.004 0.0043
Onchocerca volvulus 0.0034 0.1259 1
Loa Loa (eye worm) beta-lactamase 0.0034 0.1259 0.1259
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.1259 0.1703
Onchocerca volvulus 0.0022 0.0737 0.5718
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0006 0.004 0.0043
Echinococcus granulosus mothers against decapentaplegic 6 0.0007 0.0063 0.0031
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0757 0.0757
Schistosoma mansoni DNA helicase recq1 0.0009 0.0166 0.0231
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0187 0.8089 0.8089
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.1668 0.1668
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.1259 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0006 0.004 0.0321
Toxoplasma gondii propionate-CoA ligase 0.0006 0.004 0.0321
Trypanosoma brucei unspecified product 0.0012 0.0305 0.2419
Loa Loa (eye worm) hypothetical protein 0.0187 0.8089 0.8089
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0059 0.2389 0.3282
Brugia malayi beta-lactamase family protein 0.0034 0.1259 0.1259
Schistosoma mansoni hypothetical protein 0.0128 0.5451 0.7573
Brugia malayi MH2 domain containing protein 0.0016 0.0449 0.0449
Echinococcus granulosus dna polymerase kappa 0.0018 0.0554 0.0718
Loa Loa (eye worm) hypothetical protein 0.0009 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0034 0.1259 0.1259
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0006 0.004 0.0043
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.0554 0.077
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0554 0.4398
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.1259 0.175
Schistosoma mansoni hypothetical protein 0.0059 0.2389 0.3319
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0488 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0006 0.004 0.0321
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0006 0.004 0.0321
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0737 0.5855
Mycobacterium leprae conserved hypothetical protein 0.0034 0.1259 1
Mycobacterium tuberculosis Conserved protein 0.0034 0.1259 0.1341
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Brugia malayi MH2 domain containing protein 0.0007 0.0063 0.0063
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0006 0.004 0.0321
Loa Loa (eye worm) hypothetical protein 0.0059 0.2389 0.2389
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0448 0.0477
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0063 0.0063
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0737 0.5855
Trypanosoma brucei DNA polymerase eta, putative 0.0018 0.0554 0.4398
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0166 0.0166
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.1259 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0006 0.004 0.0043
Onchocerca volvulus 0.0034 0.1259 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0006 0.004 0.0637
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0006 0.004 0.0321
Brugia malayi AMP-binding enzyme family protein 0.0006 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0488 0.0488
Schistosoma mansoni smad1 5 8 and 0.0016 0.0449 0.0624
Brugia malayi MH1 domain containing protein 0.0016 0.0449 0.0449
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.1668 0.2317
Leishmania major DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.1259 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0448 0.0477
Schistosoma mansoni DNA helicase recq5 0.0009 0.0166 0.0231
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0006 0.004 0.0043
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0635 1
Toxoplasma gondii ABC1 family protein 0.0034 0.1259 1
Loa Loa (eye worm) nuclear factor I 0.0009 0.0137 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0737 0.5855
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.1668 0.2274
Echinococcus multilocularis mothers against decapentaplegic 2 0.0007 0.0063 0.0031
Mycobacterium ulcerans hypothetical protein 0.0034 0.1259 1
Echinococcus granulosus bloom syndrome protein 0.0023 0.0757 0.1001
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0006 0.004 0.0321
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0737 0.5718
Schistosoma mansoni smad 0.0007 0.0063 0.0087
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0007 0.0063 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0737 0.0737
Loa Loa (eye worm) hypothetical protein 0.0018 0.0554 0.0554
Echinococcus multilocularis smad 0.0016 0.0449 0.0571
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0554 0.0554
Schistosoma mansoni Smad4 0.0007 0.0063 0.0087
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.1259 0.1341
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0288 0.2032
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0059 0.2389 0.3282
Echinococcus multilocularis mothers against decapentaplegic 6 0.0007 0.0063 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0006 0.004 0.0321
Schistosoma mansoni DNA polymerase eta 0.0018 0.0554 0.077
Plasmodium vivax acetyl-CoA synthetase, putative 0.0006 0.004 0.0321
Brugia malayi MH1 domain containing protein 0.0009 0.0137 0.0137
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0288 0.3554
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0022 0.0737 0.5855
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0059 0.2389 0.2389
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0006 0.004 0.0321
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0018 0.0554 0.0718
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0449 0.0624
Brugia malayi latrophilin 2 splice variant baaae 0.0128 0.5451 0.5451
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0554 0.0554
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.1259 0.1341
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.1668 0.2317
Leishmania major acetyl-CoA synthetase, putative 0.0006 0.004 0.0321
Brugia malayi beta-lactamase family protein 0.0034 0.1259 0.1259
Loa Loa (eye worm) MH2 domain-containing protein 0.023 1 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0166 0.2996
Loa Loa (eye worm) RecQ helicase 0.0023 0.0757 0.0757
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0305 0.2419
Brugia malayi MH2 domain containing protein 0.0016 0.0449 0.0449
Echinococcus granulosus dna polymerase eta 0.0018 0.0554 0.0718
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0305 0.2419
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.1259 0.1259
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0034 0.1259 1
Echinococcus granulosus GPCR family 2 0.0059 0.2389 0.3282
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0063 0.0063
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.1259 0.1341
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0166 0.2616
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0737 0.5855
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0018 0.0554 0.0718
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0166 0.1318
Loa Loa (eye worm) hypothetical protein 0.0022 0.0737 0.0737
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0554 0.4398
Brugia malayi AMP-binding enzyme family protein 0.0006 0.004 0.004
Mycobacterium ulcerans hypothetical protein 0.0022 0.0737 0.5855
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0757 0.1001
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0006 0.004 0.0321
Loa Loa (eye worm) hypothetical protein 0.0034 0.1259 0.1259
Brugia malayi AMP-binding enzyme family protein 0.0006 0.004 0.004
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.0554 0.077
Brugia malayi beta-lactamase 0.0034 0.1259 0.1259
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0488 0.052
Mycobacterium leprae Probable lipase LipE 0.0034 0.1259 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.1259 0.1259
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0166 0.0175
Mycobacterium ulcerans beta-lactamase 0.0034 0.1259 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0737 0.0737
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.1259 0.1341
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0166 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0006 0.004 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0006 0.004 0.0321
Loa Loa (eye worm) oxidoreductase 0.0006 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0167 0.7197 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.1259 0.1259
Leishmania major DNA polymerase eta, putative 0.0018 0.0554 0.4398
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0554 0.4398
Loa Loa (eye worm) hypothetical protein 0.0022 0.0737 0.0737
Echinococcus granulosus geminin 0.0167 0.7197 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0288 0.2288
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0006 0.004 0.0321
Echinococcus granulosus smad 0.0016 0.0449 0.0571
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0554 0.4398
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0006 0.004 0.0321
Schistosoma mansoni smad1 5 8 and 0.0016 0.0449 0.0624

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 20 % Toxicity in CD-1 mouse allografted with mouse S180A cells assessed as change in body weight at maximum effective dose administered qd for 6 days (Rvb = 23.2%) ChEMBL. 181576

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.