Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0053 | 0.0297 | 0.234 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0117 | 0.0804 | 0.0791 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0103 | 0.0688 | 0.5628 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0607 | 0.4687 | 0.4679 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1212 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0044 | 0.0221 | 0.5651 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.0281 | 0.2211 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase II UvrD1 | 0.0038 | 0.0176 | 0.0161 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.0015 | 0.0213 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Treponema pallidum | ATP-dependent nuclease, subunit A | 0.0038 | 0.0176 | 0.999 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.007 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.007 |
Mycobacterium tuberculosis | Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) | 0.0607 | 0.4687 | 0.4679 |
Giardia lamblia | RNA helicase, putative | 0.0064 | 0.038 | 0.5415 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0117 | 0.0804 | 0.0791 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0017 | 0.0038 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0015 | 0.0213 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0297 | 0.2012 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.3208 |
Echinococcus multilocularis | GPCR, family 2 | 0.0053 | 0.0297 | 0.0389 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0103 | 0.0688 | 0.4804 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.038 | 0.038 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0169 | 0.1212 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1704 |
Mycobacterium tuberculosis | Possible ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0465 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit beta | 0.037 | 0.2804 | 0.2794 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0021 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0277 | 0.402 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0044 | 0.0221 | 0.147 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0117 | 0.0804 | 0.0791 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0015 | 0.0213 |
Trichomonas vaginalis | ATP-dependent DNA helicase rep, putative | 0.0038 | 0.0176 | 0.2553 |
Mycobacterium tuberculosis | Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific e | 0.0408 | 0.3107 | 0.3097 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0015 | 0.0213 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0053 | 0.0297 | 0.2357 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.0015 | 0.0213 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0169 | 0.1212 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.0904 | 0.7419 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.0281 | 0.2227 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.013 | 0.0908 | 0.0895 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.0281 | 0.0368 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0297 | 0.0389 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0044 | 0.0221 | 0.3208 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.0281 | 0.0267 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0103 | 0.0688 | 0.093 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0169 | 0.1212 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.0281 | 0.2211 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0103 | 0.0688 | 1 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1722 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase II UvrD2 | 0.0038 | 0.0176 | 0.0161 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0038 | 0.0176 | 0.0223 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.0904 | 0.7419 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0932 | 0.7263 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.025 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.013 | 0.0908 | 0.0895 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.0904 | 0.7424 |
Echinococcus granulosus | geminin | 0.0195 | 0.1417 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0176 | 0.0176 |
Giardia lamblia | Kinase, PLK | 0.0103 | 0.0688 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0053 | 0.0297 | 0.2012 |
Treponema pallidum | rep helicase, single-stranded DNA-dependent ATPase (rep) | 0.0038 | 0.0176 | 0.999 |
Treponema pallidum | hypothetical protein | 0.0038 | 0.0176 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0017 | 0.025 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1704 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0103 | 0.0688 | 0.4804 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0115 | 0.0788 | 0.6462 |
Echinococcus multilocularis | geminin | 0.0195 | 0.1417 | 0.1935 |
Wolbachia endosymbiont of Brugia malayi | superfamily I DNA/RNA helicase | 0.0038 | 0.0176 | 0.999 |
Chlamydia trachomatis | DNA helicase | 0.0038 | 0.0176 | 0.0161 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0103 | 0.0688 | 0.5618 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.0281 | 1 |
Trypanosoma cruzi | ATP-dependent DNA helicase, putative | 0.0038 | 0.0176 | 0.2391 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0.0015 | 0.0015 |
Mycobacterium tuberculosis | Probable exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide) | 0.1277 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease V (alpha chain), RecD | 0.0607 | 0.4687 | 0.4687 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1722 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0015 | 0.0213 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.013 | 0.0908 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0018 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0044 | 0.0221 | 0.147 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent exoDNAse (exonuclease V) beta subunit, RecB | 0.0038 | 0.0176 | 0.999 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0176 | 0.0002 |
Trypanosoma brucei | polo-like protein kinase | 0.0103 | 0.0688 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.0281 | 0.3958 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0044 | 0.0221 | 0.0284 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0044 | 0.0221 | 0.3208 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0044 | 0.0221 | 0.7732 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0017 | 0.0096 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.0281 | 1 |
Mycobacterium ulcerans | ATP-dependent DNA helicase II UvrD1 | 0.0038 | 0.0176 | 0.0176 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0015 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0788 | 0.6455 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0297 | 0.0389 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0117 | 0.0804 | 0.0791 |
Mycobacterium ulcerans | exodeoxyribonuclease V (gamma chain), RecC | 0.1277 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.1417 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0103 | 0.0688 | 1 |
Schistosoma mansoni | kinase | 0.0052 | 0.0288 | 0.1946 |
Mycobacterium tuberculosis | Probable reductase | 0.0117 | 0.0804 | 0.0791 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.0281 | 0.4086 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0607 | 0.4687 | 0.4679 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.0281 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Leishmania major | trypanothione reductase | 0.0051 | 0.0281 | 0.4086 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0117 | 0.0804 | 0.0791 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0017 | 0.0003 |
Treponema pallidum | DNA helicase II (uvrD) | 0.0038 | 0.0176 | 0.999 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.0038 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Brugia malayi | glutathione reductase | 0.0051 | 0.0281 | 0.2227 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.0281 | 0.7308 |
Plasmodium falciparum | ATP-dependent DNA helicase UvrD | 0.0038 | 0.0176 | 0.6042 |
Mycobacterium ulcerans | ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0478 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0017 | 0.0004 |
Mycobacterium ulcerans | ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0478 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.306 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.013 | 0.0908 | 0.0895 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0044 | 0.0221 | 0.7732 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.0788 | 0.5516 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0015 |
Mycobacterium ulcerans | exodeoxyribonuclease V (beta chain), RecB | 0.037 | 0.2804 | 0.2804 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0297 | 0.234 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0021 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.025 |
Plasmodium vivax | ATP-dependent DNA helicase UvrD, putative | 0.0038 | 0.0176 | 0.6042 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0017 | 0.0096 |
Echinococcus granulosus | hypothetical protein | 0.0038 | 0.0176 | 0.115 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0038 | 0.0176 | 0.0162 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0117 | 0.0804 | 0.8581 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0018 |
Toxoplasma gondii | UvrD/REP helicase domain-containing protein | 0.0038 | 0.0176 | 0.4416 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.0281 | 0.1901 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0053 | 0.0297 | 0.2357 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.1417 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0277 | 0.402 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0465 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.306 |
Wolbachia endosymbiont of Brugia malayi | RecB exonuclease | 0.0038 | 0.0176 | 1 |
Trypanosoma cruzi | ATP-dependent DNA helicase, putative | 0.0038 | 0.0176 | 0.2391 |
Treponema pallidum | hypothetical protein | 0.0038 | 0.0176 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0064 | 0.038 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0102 | 0.0682 | 0.6917 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0297 | 0.2012 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.3208 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.0281 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 70 % | In vitro antagonist activity at GNRHR in CD rat anterior pituitary gland assessed as inhibition of LH-RH-stimulated LH release at compound to LH-RH molar ratio of 1000 after 4 hrs by radioimmunoassay | ChEMBL. | 385877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.