Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | phosphomannose isomerase | 0.0170735 | 0.480375 | 1 |
Leishmania major | phosphomannose isomerase | 0.0170735 | 0.480375 | 1 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.00367481 | 0.0175419 | 0.0365171 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0170735 | 0.480375 | 1 |
Plasmodium falciparum | mannose-6-phosphate isomerase, putative | 0.0170735 | 0.480375 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.00367481 | 0.0175419 | 0.0175419 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.00367481 | 0.0175419 | 0.0175419 |
Mycobacterium ulcerans | mannose-6-phosphate isomerase ManA | 0.0170735 | 0.480375 | 0.5 |
Echinococcus granulosus | mannose 6 phosphate isomerase | 0.0170735 | 0.480375 | 0.480375 |
Toxoplasma gondii | phosphomannose isomerase type I protein | 0.0170735 | 0.480375 | 1 |
Entamoeba histolytica | phosphomannose isomerase, putative | 0.0170735 | 0.480375 | 1 |
Trichomonas vaginalis | mannose-6-phosphate isomerase, putative | 0.0170735 | 0.480375 | 0.5 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0170735 | 0.480375 | 1 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0321162 | 1 | 1 |
Schistosoma mansoni | mannose-6-phosphate isomerase | 0.0170735 | 0.480375 | 1 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0170735 | 0.480375 | 1 |
Mycobacterium tuberculosis | Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho | 0.00921179 | 0.208807 | 0.5 |
Mycobacterium leprae | probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO | 0.00921179 | 0.208807 | 0.5 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0170735 | 0.480375 | 1 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0170735 | 0.480375 | 1 |
Echinococcus multilocularis | mannose 6 phosphate isomerase | 0.0170735 | 0.480375 | 0.480375 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0321162 | 1 | 1 |
Plasmodium vivax | mannose-6-phosphate isomerase, putative | 0.0170735 | 0.480375 | 1 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.00367481 | 0.0175419 | 0.0365171 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0170735 | 0.480375 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 1 uM | Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition by measuring merozoite invasion of red blood cells after 48 hrs by FACS analysis | ChEMBL. | 24689770 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 24689770 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.