Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0635 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0531 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0047 | 0.8265 | 0.8246 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.4379 | 0.4695 |
Onchocerca volvulus | 0.0026 | 0.4379 | 0.2556 | |
Brugia malayi | hypothetical protein | 0.0026 | 0.4379 | 0.4709 |
Echinococcus granulosus | cpg binding protein | 0.0028 | 0.4678 | 0.5299 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0026 | 0.4379 | 0.4709 |
Brugia malayi | hypothetical protein | 0.002 | 0.3104 | 0.2974 |
Schistosoma mansoni | cpg binding protein | 0.0026 | 0.4393 | 0.4331 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0047 | 0.8265 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0047 | 0.8265 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0635 |
Onchocerca volvulus | 0.0046 | 0.8091 | 1 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0047 | 0.8265 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.0635 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0047 | 0.8265 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0047 | 0.8265 | 1 |
Onchocerca volvulus | 0.0046 | 0.8091 | 1 | |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0047 | 0.8265 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0046 | 0.8091 | 0.9763 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3104 | 0.2955 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.4379 | 0.4695 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.4379 | 0.4695 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3104 | 0.2955 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0635 |
Brugia malayi | hypothetical protein | 0.0026 | 0.4379 | 0.4709 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0047 | 0.8265 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4678 | 0.4619 |
Onchocerca volvulus | 0.0046 | 0.8091 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3104 | 0.2955 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0635 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0046 | 0.8091 | 0.9762 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0635 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0026 | 0.4379 | 0.4709 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0939 | 0.04 |
Brugia malayi | MAP kinase sur-1 | 0.0047 | 0.8265 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0026 | 0.4393 | 0.4715 |
Onchocerca volvulus | 0.0046 | 0.8091 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3104 | 0.2955 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.4379 | 0.4695 |
Onchocerca volvulus | 0.0026 | 0.4393 | 0.2585 | |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.0635 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0046 | 0.8091 | 0.9763 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0047 | 0.8265 | 0.5 |
Onchocerca volvulus | 0.0046 | 0.8091 | 1 | |
Onchocerca volvulus | 0.0046 | 0.8091 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0026 | 0.4379 | 0.4709 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0635 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4678 | 0.4619 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0047 | 0.8265 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0047 | 0.8265 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0047 | 0.8265 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0047 | 0.8265 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0047 | 0.8265 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0047 | 0.8265 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0026 | 0.4379 | 0.4695 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0046 | 0.8091 | 0.9763 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0635 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.3104 | 0.3756 |
Brugia malayi | CXXC zinc finger family protein | 0.0026 | 0.4393 | 0.4729 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0047 | 0.8265 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.4379 | 0.4695 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0047 | 0.8265 | 0.5 |
Onchocerca volvulus | 0.0046 | 0.8091 | 1 | |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0939 | 0.04 |
Brugia malayi | LBP/BPI | 0.002 | 0.3104 | 0.2974 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0047 | 0.8265 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0635 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.005 | 0.8867 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0635 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0525 | 0.0635 |
Echinococcus multilocularis | cpg binding protein | 0.0028 | 0.4678 | 0.5299 |
Onchocerca volvulus | 0.0026 | 0.4379 | 0.2556 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0026 | 0.4379 | 0.4695 |
Trypanosoma brucei | protein kinase, putative | 0.0047 | 0.8265 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0635 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.8091 | 0.9762 |
Onchocerca volvulus | 0.0046 | 0.8091 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0635 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 200 mg/kg/day | Antitumor activity against mouse L1210 cells transfected in ip dosed C3H/DBA2 F1 mouse qd administered for 5 days | ChEMBL. | 619148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.