Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin b | 0.0161 | 1 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0059 | 0.2232 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0038 | 0.0582 | 0.0582 |
Echinococcus multilocularis | cysteine protease | 0.0054 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Plasmodium vivax | vivapain-2 | 0.0054 | 0.1828 | 1 |
Onchocerca volvulus | 0.0054 | 0.1828 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0054 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0054 | 0.1828 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0054 | 0.1828 | 0.1828 |
Echinococcus multilocularis | cysteine protease | 0.0054 | 0.1828 | 0.1828 |
Toxoplasma gondii | cathepsin B | 0.0059 | 0.2232 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0054 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0054 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0054 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0054 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0161 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0059 | 0.2232 | 0.2232 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | ctsf protein | 0.0054 | 0.1828 | 0.1323 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0054 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin b | 0.0161 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0161 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0054 | 0.1828 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0054 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.0582 | 0.0582 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0054 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0038 | 0.0582 | 0.0582 |
Giardia lamblia | Cathepsin B precursor | 0.0059 | 0.2232 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0059 | 0.2232 | 0.5 |
Onchocerca volvulus | 0.0054 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0059 | 0.2232 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0054 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin b | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l1 | 0.0038 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | cathepsin B | 0.0059 | 0.2232 | 0.1752 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0054 | 0.1828 | 0.1323 |
Brugia malayi | cathepsin L-like precursor | 0.0038 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Giardia lamblia | Cathepsin B precursor | 0.0059 | 0.2232 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0161 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0054 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0059 | 0.2232 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0054 | 0.1828 | 0.1323 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0054 | 0.1828 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0054 | 0.1828 | 0.1828 |
Entamoeba histolytica | cysteine protease, putative | 0.0054 | 0.1828 | 1 |
Onchocerca volvulus | 0.0054 | 0.1828 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0054 | 0.1828 | 0.1323 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1828 | 0.1323 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0161 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0054 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1828 | 0.8189 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0054 | 0.1828 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0161 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0582 | 0.2606 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0038 | 0.0582 | 0.0582 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0161 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0059 | 0.2232 | 0.2232 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0054 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0054 | 0.1828 | 0.1828 |
Echinococcus granulosus | cathepsin l1 | 0.0054 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0054 | 0.1828 | 0.1828 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0054 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin F homolog | 0.0054 | 0.1828 | 1 |
Onchocerca volvulus | 0.0054 | 0.1828 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Plasmodium vivax | vivapain-2 | 0.0054 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | fibroinase | 0.0054 | 0.1828 | 0.1323 |
Brugia malayi | Cathepsin L-like precursor | 0.0054 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0054 | 0.1828 | 0.1828 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.0582 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0054 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0054 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0582 | 0.2606 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0054 | 0.1828 | 0.8189 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 18 mg kg-1 | Antiwrithing activity in sc dosed mouse assessed as prevention of acetylcholine-induced abdominal constriction response | ChEMBL. | 31481 |
ED50 (functional) | = 18 mg kg-1 | Analgesic activity in sc dosed Swiss-Webster mouse assessed as reduction of acetylcholine-induced writhing | ChEMBL. | 31482 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.