Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0137 | 0.4008 | 0.4008 |
Loa Loa (eye worm) | glutaminase | 0.0319 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0433 | 0.0902 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1325 | 0.1325 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0078 | 0.0078 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0433 | 0.0902 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0416 | 0.0416 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0433 | 0.0902 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0433 | 0.0433 |
Brugia malayi | TAR-binding protein | 0.0137 | 0.4008 | 0.4008 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0433 | 0.0433 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.1325 | 0.1325 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.1325 | 0.1325 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0748 | 0.0675 |
Loa Loa (eye worm) | TAR-binding protein | 0.0137 | 0.4008 | 0.4008 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0748 | 0.0748 |
Schistosoma mansoni | lamin | 0.0028 | 0.0433 | 0.0357 |
Onchocerca volvulus | 0.0028 | 0.0433 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0.0433 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0137 | 0.4008 | 0.4008 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0748 | 0.0748 |
Schistosoma mansoni | lamin | 0.0028 | 0.0433 | 0.0357 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4008 | 0.3961 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4008 | 0.3961 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4008 | 0.3961 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0433 | 0.0357 |
Loa Loa (eye worm) | glutaminase 2 | 0.0319 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4008 | 0.3961 |
Mycobacterium ulcerans | glutaminase | 0.0319 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0078 | 0.0078 |
Trichomonas vaginalis | glutaminase, putative | 0.0319 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.1325 | 0.1325 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0433 | 0.0433 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0433 | 0.0433 |
Echinococcus granulosus | tar DNA binding protein | 0.0137 | 0.4008 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0433 | 0.0902 |
Schistosoma mansoni | glutaminase | 0.0319 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0078 | 0.0078 |
Echinococcus multilocularis | tar DNA binding protein | 0.0137 | 0.4008 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0078 | 0.0078 |
Echinococcus granulosus | lamin | 0.0028 | 0.0433 | 0.0902 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0137 | 0.4008 | 0.4008 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0433 | 0.0902 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4008 | 0.3961 |
Brugia malayi | RNA binding protein | 0.0137 | 0.4008 | 0.4008 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0433 | 0.0433 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | < 1 ug ml-1 | Antifungal activity against Cryptococcus neoformans assessed as lowest dose level for total inhibition of fungal growth | ChEMBL. | 915916 |
Activity (functional) | = 10 ug ml-1 | Antifungal activity against Candida albicans assessed as lowest dose level for total inhibition of fungal growth | ChEMBL. | 915916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.