Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0763 | 0.0763 |
Echinococcus multilocularis | musashi | 0.0061 | 0.0763 | 0.0769 |
Schistosoma mansoni | intermediate filament proteins | 0.0061 | 0.0763 | 0.2373 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0058 | 0.0668 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0111 | 0.2105 | 0.2105 |
Schistosoma mansoni | lamin | 0.0061 | 0.0763 | 0.2373 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0406 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0145 | 0.301 | 0.301 |
Schistosoma mansoni | tar DNA-binding protein | 0.0145 | 0.301 | 1 |
Onchocerca volvulus | 0.0061 | 0.0763 | 1 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0058 | 0.0668 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2105 | 0.2105 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0064 | 0.0064 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0058 | 0.0668 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.1161 | 0.3722 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0111 | 0.2105 | 0.2105 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0061 | 0.0763 | 0.0763 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0064 | 0.0064 |
Echinococcus multilocularis | lamin | 0.0061 | 0.0763 | 0.0769 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.1161 | 0.1161 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0058 | 0.0668 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1161 | 0.1161 |
Echinococcus granulosus | lamin | 0.0061 | 0.0763 | 0.0769 |
Echinococcus multilocularis | tar DNA binding protein | 0.0145 | 0.301 | 0.3238 |
Echinococcus multilocularis | lamin dm0 | 0.0061 | 0.0763 | 0.0769 |
Loa Loa (eye worm) | intermediate filament protein | 0.0061 | 0.0763 | 0.0763 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0058 | 0.0668 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0058 | 0.0668 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0058 | 0.0668 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0064 | 0.0064 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0055 | 0.0589 | 0.1782 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0406 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0145 | 0.301 | 0.301 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0064 | 0.0064 |
Schistosoma mansoni | lamin | 0.0061 | 0.0763 | 0.2373 |
Echinococcus multilocularis | tumor protein p63 | 0.0374 | 0.9161 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0145 | 0.301 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0145 | 0.301 | 0.301 |
Brugia malayi | TAR-binding protein | 0.0145 | 0.301 | 0.301 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0733 | 0.0733 |
Brugia malayi | intermediate filament protein | 0.0061 | 0.0763 | 0.0763 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0111 | 0.2105 | 0.2105 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0589 | 0.0589 |
Loa Loa (eye worm) | TAR-binding protein | 0.0145 | 0.301 | 0.301 |
Echinococcus granulosus | lamin dm0 | 0.0061 | 0.0763 | 0.0769 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0119 | 0.0119 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0058 | 0.0668 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0145 | 0.301 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0668 | 0.0668 |
Brugia malayi | hypothetical protein | 0.0058 | 0.0668 | 0.0668 |
Echinococcus granulosus | tumor protein p63 | 0.0374 | 0.9161 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0061 | 0.0763 | 0.0763 |
Schistosoma mansoni | tar DNA-binding protein | 0.0145 | 0.301 | 1 |
Onchocerca volvulus | 0.0061 | 0.0763 | 1 | |
Echinococcus granulosus | tar DNA binding protein | 0.0145 | 0.301 | 0.3238 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0145 | 0.301 | 0.301 |
Echinococcus granulosus | intermediate filament protein | 0.0061 | 0.0763 | 0.0769 |
Schistosoma mansoni | tar DNA-binding protein | 0.0145 | 0.301 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | < 1 ug ml-1 | Antifungal activity against Cryptococcus neoformans assessed as lowest dose level for total inhibition of fungal growth | ChEMBL. | 915916 |
Activity (functional) | > 100 ug ml-1 | Antifungal activity against Candida albicans assessed as lowest dose level for total inhibition of fungal growth | ChEMBL. | 915916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.