Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0028 | 0.117 | 0.5 | |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0132 | 0.9182 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.19 | 0.1867 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.117 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.19 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.117 | 0.1135 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.19 | 0.2034 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.19 | 0.0826 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.117 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 0.117 | 0.1236 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.004 | 0.0342 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.19 | 0.0826 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.19 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.19 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.117 | 0.5815 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.19 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.19 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0132 | 0.9182 | 0.9178 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.117 | 0.1236 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.117 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.117 | 0.1236 |
Echinococcus multilocularis | musashi | 0.0028 | 0.117 | 0.1135 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.117 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0156 | 0.1333 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.9182 | 0.9073 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.113 | 0.9658 |
Echinococcus multilocularis | lamin | 0.0028 | 0.117 | 0.1135 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.117 | 0.5815 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.