Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.4733 | 0.4733 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0012 | 0.026 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0012 | 0.026 | 0.5 |
Echinococcus multilocularis | 0.0012 | 0.026 | 1 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0012 | 0.026 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0012 | 0.026 | 0.026 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.4733 | 0.4733 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0022 | 0.4733 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0012 | 0.026 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.026 | 0.026 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0012 | 0.026 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0012 | 0.026 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0012 | 0.026 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0022 | 0.4733 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.4733 | 0.4733 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0012 | 0.026 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0022 | 0.4733 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.4733 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 1 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0012 | 0.026 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0012 | 0.026 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0012 | 0.026 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0012 | 0.026 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0012 | 0.026 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0012 | 0.026 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.4733 | 0.4733 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0012 | 0.026 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.4733 | 1 |
Brugia malayi | cytochrome P450 | 0.0012 | 0.026 | 0.026 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0012 | 0.026 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0012 | 0.026 | 1 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.026 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0012 | 0.026 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0012 | 0.026 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0012 | 0.026 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0012 | 0.026 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0012 | 0.026 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0012 | 0.026 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0012 | 0.026 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0022 | 0.4733 | 0.4733 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0012 | 0.026 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antiplasmodial activity against drug susceptible Plasmodium falciparum 3D7 NF54 isolate in human erythrocytes assessed as growth inhibition after 48 hrs by optical microscopy | ChEMBL. | 24813729 | |
IC50 (functional) | = 0.55 uM | Antiplasmodial activity against multi-drug resistant Plasmodium falciparum K1 in human erythrocytes assessed as growth inhibition after 48 hrs by optical microscopy | ChEMBL. | 24813729 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 24813729 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.