Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosylhomocysteinase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 100 uM | Cytotoxicity against human MRC5 cells | ChEMBL. | 25456389 |
IC50 (binding) | = 9.4 nM | Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysis | ChEMBL. | 24813734 |
IC50 (binding) | = 24 nM | Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 mins | ChEMBL. | 24813734 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.