Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0011 | 0.1129 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.003 | 1 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.003 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0011 | 0.1129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.667 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0012 | 0.1831 | 0.0792 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0012 | 0.1831 | 0.0792 |
Mycobacterium ulcerans | DNA polymerase IV | 0.003 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.333 | 0.2481 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.003 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Brugia malayi | polk-prov protein | 0.0023 | 0.667 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0025 | 0.7799 | 0.7519 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0011 | 0.1129 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0016 | 0.333 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0016 | 0.333 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0011 | 0.1129 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0025 | 0.7799 | 0.7519 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.003 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.003 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.003 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.667 | 0.6246 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0012 | 0.1831 | 0.0792 |
Leishmania major | DNA polymerase kappa, putative | 0.0016 | 0.333 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0016 | 0.333 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.667 | 0.6246 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 34.6 nM | Antiproliferative against human HeLa cells after 72 hrs by MTT assay | ChEMBL. | 24835987 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24835987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.