Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0363 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0061 | 0.0448 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0061 | 0.0448 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0047 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0047 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0363 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0363 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0363 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0363 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0363 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0061 | 0.0448 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0061 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0363 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0.0448 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0448 | 0.0448 |
Echinococcus multilocularis | acetylcholinesterase | 0.0363 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0061 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | carboxylesterase | 0.0363 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0061 | 0.0448 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0061 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | carboxylesterase | 0.0061 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0448 | 0.0448 |
Onchocerca volvulus | 0.0061 | 0.0448 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0448 | 0.0448 |
Brugia malayi | Carboxylesterase family protein | 0.0363 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0047 | 0 | 0.5 |
Onchocerca volvulus | 0.0061 | 0.0448 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0061 | 0.0448 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0047 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0061 | 0.0448 | 0.0448 |
Brugia malayi | Carboxylesterase family protein | 0.0061 | 0.0448 | 0.0448 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0448 | 0.0448 |
Onchocerca volvulus | 0.0061 | 0.0448 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0.0448 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0061 | 0.0448 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC80 (functional) | = 16 ug ml-1 | Antifungal activity against Cryptococcus neoformans 32609 after 72 hrs by serial dilution method | ChEMBL. | 24900870 |
MIC80 (functional) | = 64 ug ml-1 | Antifungal activity against fluconazole-sensitive Candida albicans SC5314 after 24 hrs by serial dilution method | ChEMBL. | 24900870 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.