Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.042 uM | Inhibition of AChE (unknown origin) after 5 mins by Ellman's method | ChEMBL. | 24980117 |
IC50 (binding) | = 0.37 uM | Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins | ChEMBL. | 24938495 |
IC50 (binding) | = 38.21 uM | Inhibition of human recombinant COX2 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins | ChEMBL. | 24938495 |
IC50 (binding) | = 65.61 uM | Inhibition of soybean lipoxygenase after 5 mins by colorimetric assay | ChEMBL. | 24938495 |
IC50 (binding) | > 100 uM | Inhibition of BuChE (unknown origin) after 5 mins by Ellman's method | ChEMBL. | 24980117 |
Inhibition (binding) | = 65 % | Inhibition of soybean lipoxygenase after 5 mins by colorimetric assay | ChEMBL. | 24938495 |
Inhibition (binding) | = 67.57 % | Inhibition of soybean lipoxygenase at 40 ug/mL after 5 mins by colorimetric assay | ChEMBL. | 24938495 |
Inhibition (functional) | = 73 % | Inhibition of TNFalpha expression in mouse RAW264.7 cells at 10 uM per-treated with compound for 2 hrs before LPS challenge for 22 hrs by ELISA method | ChEMBL. | 24938495 |
Inhibition (binding) | = 81.79 % | Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins | ChEMBL. | 24938495 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.