Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0079 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0 | 0.5 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of soybean lipoxygenase after 5 mins by colorimetric assay | ChEMBL. | 24938495 | |
IC50 (binding) | = 2.73 uM | Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins | ChEMBL. | 24938495 |
IC50 (binding) | = 14.66 uM | Inhibition of BuChE (unknown origin) after 5 mins by Ellman's method | ChEMBL. | 24980117 |
IC50 (binding) | = 14.76 uM | Inhibition of human recombinant COX2 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins | ChEMBL. | 24938495 |
IC50 (binding) | = 76.64 uM | Inhibition of AChE (unknown origin) after 5 mins by Ellman's method | ChEMBL. | 24980117 |
Inhibition (functional) | = 73 % | Inhibition of TNFalpha expression in mouse RAW264.7 cells at 10 uM per-treated with compound for 2 hrs before LPS challenge for 22 hrs by ELISA method | ChEMBL. | 24938495 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.