Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.00121494 | 0.0592477 | 0.0592477 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.00267279 | 1 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.00121494 | 0.0592477 | 0.0592477 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.00267279 | 1 | 0.5 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Echinococcus multilocularis | beta tubulin | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.00267279 | 1 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.00267279 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.00267279 | 1 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.00267279 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Trichomonas vaginalis | tubulin, putative | 0.00267279 | 1 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.00267279 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.00267279 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.00121494 | 0.0592477 | 0.0592477 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.00267279 | 1 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.00267279 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.00267279 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.00121494 | 0.0592477 | 0.0592477 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.00267279 | 1 | 0.5 |
Loa Loa (eye worm) | tubulin beta chain | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Toxoplasma gondii | beta tubulin | 0.00267279 | 1 | 0.5 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.00267279 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.00112312 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.00121494 | 0.0592477 | 0.5 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Brugia malayi | Tubulin beta-1 chain | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.00121494 | 0.0592477 | 0.0592477 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.00267279 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Trypanosoma cruzi | beta tubulin, putative | 0.00267279 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.00267279 | 1 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.00267279 | 1 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.00267279 | 1 | 0.5 |
Giardia lamblia | Beta tubulin | 0.00267279 | 1 | 0.5 |
Giardia lamblia | Beta tubulin | 0.00267279 | 1 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.00267279 | 1 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.00267279 | 1 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.00267279 | 1 | 1 |
Brugia malayi | beta-tubulin, identical | 0.00267279 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.00267279 | 1 | 1 |
Echinococcus multilocularis | beta tubulin | 0.00267279 | 1 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.00112312 | 0 | 0.5 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.00267279 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.00267279 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.00267279 | 1 | 1 |
Onchocerca volvulus | 0.00112312 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.00267279 | 1 | 1 |
Leishmania major | beta tubulin | 0.00267279 | 1 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.00267279 | 1 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.00267279 | 1 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.00267279 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.62 uM | Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis | ChEMBL. | 24904967 |
IC50 (functional) | = 1 uM | Antimalarial activity against late stage gametocyte stage of Plasmodium falciparum NF54 after 72 hrs | ChEMBL. | 24904967 |
IC50 (functional) | = 1.13 uM | Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs | ChEMBL. | 24904967 |
IC50 (ADMET) | = 8.03 uM | Cytotoxicity against human HepG2 cells after 48 hrs | ChEMBL. | 24904967 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24904967 | |
Plasmodium falciparum | 24904967 | ||
Plasmodium berghei | ChEMBL23 | 24904967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.