Detailed information for compound 1923354

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 580.535 | Formula: C27H32O14
  • H donors: 8 H acceptors: 9 LogP: -0.51 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)O[C@@H](CC3=O)c2ccc(cc2)O)[C@@H]([C@H]([C@@H]1O)O)O[C@@H]1O[C@H](C)[C@H]([C@@H]([C@H]1O)O)O
  • InChi: 1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16+,18-,20-,21-,22+,23+,24-,25-,26+,27-/m1/s1
  • InChiKey: DFPMSGMNTNDNHN-BJKFASDXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus peroxidasin 0.0026 0.0302 0.0197
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0876 0.358
Leishmania major importin beta-1 subunit, putative 0.0023 0.0211 0.0864
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0046 0.0959 0.1196
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0046 0.0959 0.3921
Loa Loa (eye worm) fli-1 protein 0.0265 0.8026 0.8764
Schistosoma mansoni ran 0.0021 0.0144 0.004
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1939 0.2024
Mycobacterium ulcerans lipase LipD 0.0043 0.0876 0.2579
Onchocerca volvulus Peroxidase homolog 0.0026 0.0302 0.0475
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0053 0.1178 0.4903
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0026 0.03 0.0221
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0876 0.358
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0107 0.0133
Schistosoma mansoni hypothetical protein 0.0039 0.0743 0.0703
Echinococcus granulosus Ankyrin 0.0034 0.0556 0.0454
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.002 0.0135 0.055
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0117
Giardia lamblia Kinase, PLK 0.0092 0.2447 1
Schistosoma mansoni gabp alpha 0.0087 0.2292 0.2414
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.079 0.2808
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0087 0.2263 0.6337
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1939 0.2024
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.2447 0.9617
Schistosoma mansoni hypothetical protein 0.0205 0.6065 0.6583
Brugia malayi Importin beta-1 subunit 0.0028 0.0383 0.0477
Plasmodium vivax importin-beta 2, putative 0.0028 0.0383 0.3011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0081 0.21 0.581
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.1552 0.1934
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0876 0.318
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.2447 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.2447 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1939 0.1852
Echinococcus multilocularis protein patched 0.0041 0.079 0.0691
Mycobacterium tuberculosis Conserved protein 0.0025 0.0266 0.018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1383 0.4071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0107 0.0133
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0076 0.1928 0.218
Mycobacterium leprae Probable lipase LipE 0.0043 0.0876 0.1859
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1552 0.6344
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.002 0.0135 0.055
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.21 0.6181
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0302 0.0475
Echinococcus granulosus death domain containing protein 0.0033 0.0552 0.045
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0068 0.1663 0.4398
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0876 0.2579
Mycobacterium ulcerans polyketide synthase Pks9 0.0054 0.1211 0.3565
Loa Loa (eye worm) hypothetical protein 0.0043 0.0876 0.0957
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0087 0.2263 0.666
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.002 0.0135 0.5
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.2447 0.2365
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0081 0.21 0.581
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.002 0.0135 0.0396
Brugia malayi Peroxidasin 0.0026 0.0302 0.0376
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0171 0.4971 0.4917
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0107 0.0117
Entamoeba histolytica hypothetical protein 0.0035 0.0595 0.1886
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.002 0.0135 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0107 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0107 0.0117
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0079 0.202 0.2291
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0876 0.0777
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.2447 0.5709
Schistosoma mansoni patched 1 0.0041 0.079 0.0755
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.9158 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1383 0.1525
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0876 0.358
Echinococcus granulosus geminin 0.0205 0.6065 0.6023
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1939 0.2024
Schistosoma mansoni peroxidasin 0.0026 0.0302 0.0215
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.1552 0.1695
Onchocerca volvulus 0.0142 0.4043 0.9602
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0302 0.0376
Brugia malayi Blistered cuticle protein 3 0.0026 0.0302 0.0376
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0283 0.0352
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0087 0.2263 0.2584
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.2539 0.3163
Schistosoma mansoni jun-related protein 0.0139 0.3942 0.4237
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0117
Loa Loa (eye worm) acyl carrier protein 0.0037 0.0683 0.0745
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0107 0.0133
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.002 0.0135 0.0028
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0144 0.0587
Schistosoma mansoni peroxidasin 0.0026 0.0302 0.0215
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0876 0.085
Schistosoma mansoni hypothetical protein 0.0039 0.0743 0.0703
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0211 0.0295
Echinococcus granulosus importin subunit beta 1 0.0028 0.0383 0.0279
Echinococcus granulosus netrin receptor unc 5 0.0033 0.0552 0.045
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0046 0.0959 0.3921
Schistosoma mansoni kinase 0.0047 0.0986 0.0971
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0066 0.1587 0.4155
Loa Loa (eye worm) hypothetical protein 0.0043 0.0876 0.0957
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0107 0.0133
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0678 0.0577
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0107 0.0133
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0302 0.0329
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0087 0.2263 0.2584
Brugia malayi beta-lactamase family protein 0.0043 0.0876 0.1092
Brugia malayi hypothetical protein 0.0035 0.0595 0.0742
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1383 0.141
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0107 0.0133
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1383 0.129
Onchocerca volvulus Peroxidase homolog 0.0026 0.0302 0.0475
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0678 0.0577
Loa Loa (eye worm) RNA binding protein 0.0076 0.1939 0.2118
Loa Loa (eye worm) fatty acid synthase 0.008 0.2065 0.2255
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Mycobacterium leprae Probable polyketide synthase Pks1 0.0087 0.2263 0.6337
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0144 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0107 0.0133
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0144 0.0042
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0302 0.0376
Mycobacterium tuberculosis Probable thioesterase TesA 0.0068 0.1663 0.1861
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0107 0.0117
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0211 0.0864
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.1552 0.1597
Schistosoma mansoni hypothetical protein 0.0039 0.0743 0.0703
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.2447 0.2585
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.2539 0.2458
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.002 0.0135 0.5
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.002 0.0135 0.055
Schistosoma mansoni hypothetical protein 0.0039 0.0743 0.0703
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0302 0.0329
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1552 0.6344
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0876 0.318
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.2539 0.2458
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0046 0.0959 0.3406
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0266 0.0534
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0041 0.0802 0.3136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0028 0.0378 0.0314
Schistosoma mansoni ankyrin 23/unc44 0.0033 0.0552 0.0492
Schistosoma mansoni importin beta-1 0.0028 0.0383 0.0305
Loa Loa (eye worm) hypothetical protein 0.0046 0.0946 0.1033
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0144 0.0587
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0033 0.0552 0.045
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0122 0.3398 0.3951
Onchocerca volvulus 0.0043 0.0876 0.1876
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0876 0.0957
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0107 0.0117
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0107 0.0133
Mycobacterium tuberculosis Hypothetical protein 0.0025 0.0266 0.018
Echinococcus granulosus tar DNA binding protein 0.0076 0.1939 0.1852
Schistosoma mansoni hypothetical protein 0.0035 0.0595 0.0539
Loa Loa (eye worm) hypothetical protein 0.0137 0.3884 0.4241
Onchocerca volvulus 0.0043 0.0876 0.1876
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.2447 0.2672
Toxoplasma gondii ABC1 family protein 0.0043 0.0876 0.3484
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0081 0.21 0.6181
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0033 0.0552 0.045
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0107 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Brugia malayi ecdysteroid receptor 0.002 0.0107 0.0133
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0046 0.0959 0.3921
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0046 0.0959 0.1048
Onchocerca volvulus 0.0026 0.0302 0.0475
Echinococcus granulosus jun protein 0.0171 0.4971 0.4917
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0302 0.0475
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2447 1
Brugia malayi Ets-domain containing protein 0.0087 0.2292 0.2856
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0302 0.0376
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0595 0.0493
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0046 0.0959 0.1196
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0117
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.2447 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1939 0.2416
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0876 0.085
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0117
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0144 0.0157
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0302 0.0376
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0876 0.2579
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2447 1
Schistosoma mansoni hypothetical protein 0.0205 0.6065 0.6583
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0046 0.0959 0.0862
Loa Loa (eye worm) hypothetical protein 0.0043 0.0876 0.0957
Echinococcus granulosus snurportin 1 0.0301 0.9158 0.9149
Brugia malayi bZIP transcription factor family protein 0.0171 0.4971 0.6194
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1383 0.141
Schistosoma mansoni hypothetical protein 0.005 0.11 0.1098
Echinococcus multilocularis expressed conserved protein 0.0089 0.2353 0.227
Loa Loa (eye worm) hypothetical protein 0.0028 0.0383 0.0418
Giardia lamblia Methyltransferase like 2 0.0025 0.0266 0.0534
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2447 1
Onchocerca volvulus 0.0026 0.0302 0.0475
Mycobacterium leprae Polyketide synthase Pks13 0.0122 0.3398 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.1552 0.5881
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0107 0.0133
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0117
Leishmania major hypothetical protein, conserved 0.0025 0.0266 0.1089
Schistosoma mansoni hypothetical protein 0.0033 0.0552 0.0492
Brugia malayi Ets-domain containing protein 0.0087 0.2292 0.2856
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0107 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2447 1
Schistosoma mansoni netrin receptor unc5 0.0033 0.0552 0.0492
Brugia malayi TAR-binding protein 0.0076 0.1939 0.2416
Mycobacterium ulcerans polyketide synthase 0.0081 0.21 0.6181
Brugia malayi Death domain containing protein 0.0033 0.0552 0.0688
Brugia malayi RNA, U transporter 1 0.008 0.2055 0.2561
Brugia malayi steroid hormone receptor 0.002 0.0107 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0595 0.0493
Schistosoma mansoni hypothetical protein 0.0301 0.9158 1
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0876 0.0914
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.079 0.0691
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.2539 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Onchocerca volvulus 0.0076 0.1928 0.4441
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0117
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0054 0.1211 0.2941
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.2447 0.3049
Brugia malayi Protein kinase domain containing protein 0.0034 0.0562 0.07
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0033 0.0537 0.0506
Trichomonas vaginalis esterase, putative 0.0043 0.0876 0.318
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.21 0.6181
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1939 0.2024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0211 0.0295
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0947 0.3487
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0081 0.21 0.2388
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0107 0.0133
Loa Loa (eye worm) hypothetical protein 0.005 0.1086 0.1186
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0876 0.318
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0876 0.318
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0087 0.2263 0.666
Mycobacterium ulcerans polyketide synthase MbtD 0.0025 0.0283 0.0832
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0552 0.0603
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0302 0.0475
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0046 0.0959 0.3876
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.002 0.0135 0.0168
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1383 0.129
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0171 0.4971 0.4917
Mycobacterium tuberculosis Conserved protein 0.0043 0.0876 0.0914
Brugia malayi AMP-binding enzyme family protein 0.0076 0.1928 0.2402
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0117
Entamoeba histolytica hypothetical protein 0.0035 0.0595 0.1886
Mycobacterium ulcerans polyketide synthase MbtC 0.002 0.0135 0.0396
Echinococcus multilocularis protein dispatched 1 0.0047 0.0976 0.0878
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0383 0.1565
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0079 0.202 0.2291
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0876 0.1092
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0046 0.0959 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0107 0.0133
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.002 0.0135 0.0396
Schistosoma mansoni ets-related 0.0265 0.8026 0.8749
Onchocerca volvulus Fatty acid synthase homolog 0.0147 0.4206 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2447 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0383 0.1167
Onchocerca volvulus 0.0026 0.0302 0.0475
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0046 0.0959 0.3921
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0046 0.0959 0.0862
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.2447 0.2365
Mycobacterium tuberculosis Conserved protein 0.0043 0.0876 0.0914
Entamoeba histolytica hypothetical protein 0.0023 0.0211 0.0284
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0046 0.0959 0.3542
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0034 0.0556 0.0496
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0144 0.0108
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0081 0.21 0.2388
Brugia malayi Fli-1 protein 0.0265 0.8026 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0087 0.2263 0.6337
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0876 0.0914
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0876 0.899
Brugia malayi nuclear hormone receptor 0.002 0.0107 0.0133
Echinococcus granulosus expressed conserved protein 0.0089 0.2353 0.227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0107 0.0117
Plasmodium falciparum importin beta, putative 0.0028 0.0383 0.3011
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.3853 0.3787
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0046 0.0959 0.0942
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0144 0.0037
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0876 0.1859
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2447 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0066 0.1587 0.4672
Echinococcus multilocularis netrin receptor unc 5 0.0033 0.0552 0.045
Schistosoma mansoni ran 0.0021 0.0144 0.004
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.002 0.0135 0.0147
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.079 0.0863
Trypanosoma brucei polo-like protein kinase 0.0092 0.2447 1
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0302 0.0329
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0876 0.0914
Loa Loa (eye worm) hypothetical protein 0.0033 0.0552 0.0603
Mycobacterium ulcerans thioesterase TesA 0.0068 0.1663 0.4893
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0087 0.2263 0.2584
Brugia malayi nuclear receptor NHR-88 0.002 0.0107 0.0133
Toxoplasma gondii type I fatty acid synthase, putative 0.0087 0.2263 1
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.002 0.0135 0.055
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1383 0.5866
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0107 0.0117
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0552 0.0688
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0876 0.0914
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.3853 0.3787
Brugia malayi beta-lactamase 0.0043 0.0876 0.1092
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0383 0.0279
Echinococcus granulosus Protein patched homolog 1 0.0041 0.079 0.0691
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Mycobacterium ulcerans hypothetical protein 0.0043 0.0876 0.2579
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.2586 0.2739
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0067 0.1622 0.1812
Loa Loa (eye worm) hypothetical protein 0.0034 0.0556 0.0608
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0302 0.0376
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.1344 0.5682
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1383 0.5652
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0876 0.0914
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1939 0.2118
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0025 0.0283 0.0199
Echinococcus multilocularis Ankyrin 0.0034 0.0556 0.0454
Loa Loa (eye worm) hypothetical protein 0.0166 0.482 0.5264
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0117
Onchocerca volvulus Netrin receptor homolog 0.0033 0.0552 0.1086
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0066 0.1587 0.4672
Mycobacterium ulcerans beta-lactamase 0.0043 0.0876 0.2579
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0327 1 1
Schistosoma mansoni methyltransferase-related 0.0025 0.0266 0.0176
Entamoeba histolytica hypothetical protein 0.0035 0.0595 0.1886
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0154 0.4449 0.5544
Loa Loa (eye worm) hypothetical protein 0.0043 0.0876 0.0957
Brugia malayi hypothetical protein 0.0026 0.0302 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0107 0.0133
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0059 0.1361 0.1498
Mycobacterium ulcerans polyketide synthase Pks13 0.0122 0.3398 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0076 0.1928 0.2105
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.1552 0.1461
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0144 0.0179
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0876 0.0777
Entamoeba histolytica hypothetical protein 0.0035 0.0595 0.1886
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Brugia malayi Methyltransferase-like protein 4 0.0025 0.0266 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1939 0.2024
Mycobacterium ulcerans thioesterase 0.0068 0.1663 0.4893
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1939 0.2118
Brugia malayi Uncoordinated protein 44 0.0033 0.0552 0.0688
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0046 0.0968 0.1024
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0046 0.0959 0.1048
Echinococcus multilocularis geminin 0.0205 0.6065 0.6023
Onchocerca volvulus 0.0134 0.3791 0.8987
Onchocerca volvulus 0.0043 0.0876 0.1876
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.2292 0.2209
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0046 0.0959 0.3542
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0107 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0947 0.3487
Loa Loa (eye worm) hypothetical protein 0.0041 0.079 0.0863
Schistosoma mansoni hypothetical protein 0.0139 0.3942 0.4237
Mycobacterium tuberculosis Conserved protein 0.0043 0.0876 0.0914
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2447 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0876 0.0957
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0054 0.1211 0.3565
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.8421 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.2292 0.2503
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.079 0.0691
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0302 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0107 0.0133
Leishmania major hypothetical protein, conserved 0.0043 0.0876 0.358
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0302 0.0329
Echinococcus multilocularis jun protein 0.0171 0.4971 0.4917
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.002 0.0135 0.0028
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0876 0.0914
Brugia malayi beta-lactamase family protein 0.0043 0.0876 0.1092
Mycobacterium ulcerans fatty acid synthase Fas 0.0026 0.03 0.0884
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0046 0.0959 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0876 0.0957
Echinococcus multilocularis snurportin 1 0.0301 0.9158 0.9149
Loa Loa (eye worm) hypothetical protein 0.0043 0.0876 0.0957
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1383 0.4071
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0211 0.0295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0107 0.0117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0876 0.0914
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0876 0.318
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.2292 0.2209
Brugia malayi RNA binding protein 0.0076 0.1939 0.2416
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0144 0.0037
Echinococcus multilocularis peroxidasin 0.0026 0.0302 0.0197
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0081 0.21 0.2617
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0144 0.0108
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0595 0.0539
Brugia malayi CHE-14 protein 0.0041 0.079 0.0985
Loa Loa (eye worm) hypothetical protein 0.0075 0.1884 0.2057
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1552 0.6344
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0122 0.3398 0.3951
Loa Loa (eye worm) hypothetical protein 0.0095 0.2539 0.2772
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.1552 0.6344
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1383 0.4071
Brugia malayi hypothetical protein 0.0134 0.3791 0.4724
Loa Loa (eye worm) hypothetical protein 0.0026 0.0302 0.0329
Leishmania major GTP-binding protein, putative 0.0021 0.0144 0.0587
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0081 0.21 0.2388
Mycobacterium ulcerans polyketide synthase 0.0087 0.2263 0.666
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0383 0.1565
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.21 0.6181
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0302 0.0475
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.1552 0.1461

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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