Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0071 | 0.2636 | 0.2636 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.0839 | 0.0839 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0061 | 0.1851 | 0.1851 |
Echinococcus granulosus | cathepsin b | 0.0161 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0071 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0071 | 0.2636 | 0.1962 |
Onchocerca volvulus | Cathepsin F homolog | 0.0071 | 0.2636 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0071 | 0.2636 | 0.2636 |
Echinococcus granulosus | cathepsin l1 | 0.0071 | 0.2636 | 0.2636 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0071 | 0.2636 | 0.2636 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.6803 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0071 | 0.2636 | 0.1962 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0071 | 0.2636 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.2636 | 0.2636 |
Entamoeba histolytica | cysteine protease, putative | 0.0071 | 0.2636 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0071 | 0.2636 | 0.1586 |
Loa Loa (eye worm) | fibroinase | 0.0071 | 0.2636 | 0.1962 |
Echinococcus multilocularis | cysteine protease | 0.0071 | 0.2636 | 0.2636 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0161 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0161 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.2636 | 0.1586 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0049 | 0.0839 | 0.0839 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0071 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0061 | 0.1851 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0061 | 0.1851 | 0.5 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0049 | 0.0839 | 0.0839 |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.2636 | 0.2636 |
Onchocerca volvulus | 0.0071 | 0.2636 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.6803 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0071 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.0839 | 0.3182 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0161 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0071 | 0.2636 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.6803 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0071 | 0.2636 | 0.2636 |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.2636 | 0.2636 |
Giardia lamblia | Cathepsin B precursor | 0.0061 | 0.1851 | 0.5 |
Echinococcus granulosus | cathepsin l1 | 0.0049 | 0.0839 | 0.0839 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0049 | 0.0839 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0071 | 0.2636 | 0.2636 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0071 | 0.2636 | 0.1962 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.2636 | 0.1586 |
Loa Loa (eye worm) | cathepsin B | 0.0061 | 0.1851 | 0.1105 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0122 | 0.6803 | 0.6803 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2636 | 0.1962 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0061 | 0.1851 | 0.1851 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0071 | 0.2636 | 0.2636 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.2636 | 0.1586 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0071 | 0.2636 | 0.2636 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.6803 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.2636 | 0.2636 |
Echinococcus multilocularis | cathepsin b | 0.0161 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.6803 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0068 | 0.2369 | 0.2369 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0122 | 0.6803 | 0.6803 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0122 | 0.6803 | 0.6803 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.6803 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0071 | 0.2636 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.6803 | 1 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.2636 | 0.1586 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.2636 | 0.1586 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0161 | 1 | 1 |
Onchocerca volvulus | 0.0071 | 0.2636 | 1 | |
Onchocerca volvulus | 0.0071 | 0.2636 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0161 | 1 | 1 |
Onchocerca volvulus | 0.0071 | 0.2636 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0122 | 0.6803 | 1 |
Leishmania major | cathepsin L-like protease | 0.0122 | 0.6803 | 1 |
Leishmania major | cathepsin L-like protease | 0.0122 | 0.6803 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.2636 | 0.2636 |
Brugia malayi | cathepsin L-like precursor | 0.0049 | 0.0839 | 0.0839 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.6803 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0061 | 0.1851 | 0.2721 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0071 | 0.2636 | 0.1962 |
Echinococcus multilocularis | cathepsin b | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0071 | 0.2636 | 0.2636 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0071 | 0.2636 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0071 | 0.2636 | 0.2636 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Onchocerca volvulus | 0.0071 | 0.2636 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0071 | 0.2636 | 0.2636 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0071 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.2636 | 0.2636 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.6803 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.6803 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0122 | 0.6803 | 0.6803 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.6803 | 1 |
Echinococcus granulosus | cathepsin b | 0.0161 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0061 | 0.1851 | 0.7022 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.0839 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.01 | 0.5006 | 0.5006 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.0839 | 0.0839 |
Onchocerca volvulus | 0.0071 | 0.2636 | 1 | |
Onchocerca volvulus | 0.0071 | 0.2636 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0071 | 0.2636 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0071 | 0.2636 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.2636 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 44.5 % | Inhibition of BRD4 bromodomain-1 (unknown origin) at 100 uM by europium based LANCE TR-FRET assay | ChEMBL. | 25678016 |
Inhibition (binding) | < 50 % | Inhibition of BRD4 bromodomain-1 (unknown origin) at 300 uM by europium based LANCE TR-FRET assay | ChEMBL. | 25678016 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.