TDR Targets

Basic information

Technical information

TDR Targets ID: 1923435
Name: [(3S)-oxolan-3-yl] N-[(2S,3S)-4-[(4-aminophen yl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy- 1-phenylbutan-2-yl]carbamate
MW: 505.627 | Formula: C25H35N3O6S
H donors: 3 H acceptors: 4 LogP: 2.89 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: CC(CN(S(=O)(=O)c1ccc(cc1)N)C[C@@H]([C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)O)C
InChi: 1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24-/m0/s1
InChiKey: YMARZQAQMVYCKC-XWGVYQGASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[(3S)-tetrahydrofuran-3-yl] N-[(1S,2S)-3-[(4-aminophenyl)sulfonyl-isobutyl-amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamate
N-[(1S,2S)-3-[(4-aminophenyl)sulfonyl-isobutylamino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid [(3S)-3-tetrahydrofuranyl] ester
N-[(1S,2S)-3-[(4-aminophenyl)sulfonyl-isobutyl-amino]-1-(benzyl)-2-hydroxy-propyl]carbamic acid [(3S)-tetrahydrofuran-3-yl] ester
[(3S)-oxolan-3-yl] N-[(2S,3S)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenyl-butan-2-yl]carbamate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.1289	0.4186	1
Brugia malayi	Cytochrome P450 family protein	0.0034	0.0054	0.013
Echinococcus granulosus	rhodopsin orphan GPCR	0.1289	0.4186	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.1289	0.4186	0.4157
Onchocerca volvulus		0.1289	0.4186	1
Echinococcus multilocularis	neuropeptides capa receptor	0.1289	0.4186	1
Echinococcus granulosus	neuropeptides capa receptor	0.1289	0.4186	1
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0059	0.0137	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0146	0.0233
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0059	0.0137	0.0327
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1289	0.4186	0.4157
Schistosoma mansoni	hypothetical protein	0.1289	0.4186	0.4157
Brugia malayi	Melatonin receptor type 1A	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0556	0.1771	0.173
Echinococcus multilocularis	dro:myosuppressin receptor	0.1289	0.4186	1
Schistosoma mansoni	neuropeptide receptor	0.1289	0.4186	0.4157
Echinococcus granulosus	g-protein coupled receptor	0.1289	0.4186	1
Onchocerca volvulus		0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus granulosus	g protein coupled receptor	0.1289	0.4186	1
Onchocerca volvulus		0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1289	0.4186	0.4157
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus granulosus	neuropeptide receptor	0.1289	0.4186	1
Echinococcus multilocularis	sex peptide receptor	0.1289	0.4186	1
Schistosoma mansoni	amine GPCR	0.1289	0.4186	0.4157
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0059	0.0137	0.0087
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1289	0.4186	0.4157
Trypanosoma brucei	cytochrome P450, putative	0.0034	0.0054	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.1289	0.4186	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0146	0.0097
Brugia malayi	hypothetical protein	0.1289	0.4186	1
Trypanosoma cruzi	cytochrome P450, putative	0.0034	0.0054	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.1289	0.4186	0.4157
Plasmodium falciparum	plasmepsin IV	0.0059	0.0137	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.1289	0.4186	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.1289	0.4186	0.4157
Onchocerca volvulus		0.1289	0.4186	1
Toxoplasma gondii	aspartyl protease ASP1	0.0059	0.0137	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0048	0.0114
Brugia malayi	G-protein coupled receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.1289	0.4186	0.4157
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	neuropeptide receptor A26	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Brugia malayi	G-protein coupled receptor	0.1289	0.4186	1
Schistosoma mansoni	amine GPCR	0.1289	0.4186	0.4157
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus granulosus	neuropeptide Y receptor	0.1289	0.4186	1
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0146	0.0349
Echinococcus multilocularis	serotonin receptor	0.1289	0.4186	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1289	0.4186	0.4157
Loa Loa (eye worm)	CYP4Cod1	0.0034	0.0054	0.013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1289	0.4186	0.4157
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0146	0.0233
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.0515	0.0468
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.1289	0.4186	1
Plasmodium falciparum	plasmepsin I	0.0059	0.0137	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.1289	0.4186	1
Onchocerca volvulus		0.1289	0.4186	1
Brugia malayi	RE15519p	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus granulosus	7tm_1 domain containing protein	0.1289	0.4186	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1289	0.4186	1
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0059	0.0137	0.5
Onchocerca volvulus		0.1289	0.4186	1
Brugia malayi	TAR-binding protein	0.0062	0.0146	0.0349
Brugia malayi	Serotonin receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.1289	0.4186	1
Echinococcus multilocularis	S formylglutathione hydrolase	0.0039	0.0072	0.0053
Schistosoma mansoni	opsin-like receptor	0.1289	0.4186	0.4157
Brugia malayi	sulfakinin receptor protein	0.1289	0.4186	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.1289	0.4186	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.005	0.0119
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Plasmodium vivax	plasmepsin IV, putative	0.0059	0.0137	0.5
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0059	0.0137	0.021
Echinococcus granulosus	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.1289	0.4186	1
Schistosoma mansoni	hypothetical protein	0.1289	0.4186	0.4157
Echinococcus granulosus	serotonin receptor	0.1289	0.4186	1
Brugia malayi	G protein-coupled receptor	0.1289	0.4186	1
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0072	0.0059
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.1289	0.4186	1
Echinococcus granulosus	tm gpcr rhodopsin	0.1289	0.4186	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0034	0.0054	0.013
Echinococcus granulosus	neuropeptide Y receptor	0.1289	0.4186	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.1289	0.4186	1
Echinococcus multilocularis	fmrfamide receptor	0.1289	0.4186	1
Mycobacterium tuberculosis	Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)	0.0924	0.2985	1
Trypanosoma cruzi	cytochrome P450, putative	0.0034	0.0054	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.1289	0.4186	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0146	0.0097
Onchocerca volvulus		0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.1289	0.4186	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1289	0.4186	0.4157
Brugia malayi	putative neuropeptide receptor	0.1289	0.4186	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.1289	0.4186	1
Brugia malayi	GnHR receptor homolog	0.1289	0.4186	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.1289	0.4186	1
Plasmodium falciparum	plasmepsin VI	0.0059	0.0137	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.1289	0.4186	0.4157
Echinococcus multilocularis	g-protein coupled receptor	0.1289	0.4186	1
Echinococcus multilocularis	serotonin receptor	0.1289	0.4186	1
Brugia malayi	Cytochrome P450 family protein	0.0034	0.0054	0.013
Brugia malayi	hypothetical protein	0.1289	0.4186	1
Brugia malayi	ORL1-like opioid receptor	0.1289	0.4186	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1289	0.4186	0.4157
Echinococcus granulosus	tm gpcr rhodopsin	0.1289	0.4186	1
Mycobacterium ulcerans	secreted antigen 85-B FbpB	0.0039	0.0072	0.0059
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Schistosoma mansoni	amine GPCR	0.1289	0.4186	0.4157
Loa Loa (eye worm)	melatonin receptor type 1A	0.1289	0.4186	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.1289	0.4186	0.4157
Echinococcus granulosus	tachykinin peptides receptor 99D	0.1289	0.4186	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.1289	0.4186	0.4157
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0146	0.0097
Brugia malayi	Esterase D	0.0039	0.0072	0.0172
Loa Loa (eye worm)	neuropeptide F receptor	0.1289	0.4186	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.1289	0.4186	1
Onchocerca volvulus		0.1289	0.4186	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.1289	0.4186	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.1289	0.4186	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1289	0.4186	1
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0146	0.0349
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Brugia malayi	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.1289	0.4186	1
Echinococcus multilocularis	g protein coupled receptor	0.1289	0.4186	1
Loa Loa (eye worm)	esterase D	0.0039	0.0072	0.0172
Brugia malayi	Dopamine receptor	0.1289	0.4186	1
Mycobacterium ulcerans	secreted antigen 85-A FbpA	0.0039	0.0072	0.0059
Brugia malayi	neuropeptide F receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0012	0.0029
Echinococcus granulosus	rhodopsin orphan GPCR	0.1289	0.4186	1
Mycobacterium ulcerans	secreted Mpt51/Mpb51 antigen protein FbpD	0.0039	0.0072	0.0059
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Entamoeba histolytica	endo-1,4-beta-xylanase, putative	0.0039	0.0072	0.5
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	neuropeptide Y receptor	0.1289	0.4186	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1289	0.4186	0.4157
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.1289	0.4186	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1289	0.4186	1
Echinococcus granulosus	g protein coupled receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Schistosoma mansoni	amine GPCR	0.1289	0.4186	0.4157
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0072	0.0059
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.1289	0.4186	1
Mycobacterium leprae	SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C)	0.0924	0.2985	1
Brugia malayi	hypothetical protein	0.1289	0.4186	1
Echinococcus granulosus	neuropeptide receptor	0.1289	0.4186	1
Schistosoma mansoni	biogenic amine receptor	0.1289	0.4186	0.4157
Schistosoma mansoni	neuropeptide receptor	0.1289	0.4186	0.4157
Onchocerca volvulus		0.1289	0.4186	1
Schistosoma mansoni	opsin-like receptor	0.1289	0.4186	0.4157
Schistosoma mansoni	histamine h1 receptor	0.1289	0.4186	0.4157
Echinococcus multilocularis	fmrfamide receptor	0.1289	0.4186	1
Echinococcus multilocularis	G protein coupled receptor 139	0.1289	0.4186	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.1289	0.4186	1
Echinococcus multilocularis	neuropeptides capa receptor	0.1289	0.4186	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.1289	0.4186	0.4157
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1289	0.4186	0.4157
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Schistosoma mansoni	biogenic amine receptor	0.1289	0.4186	0.4157
Schistosoma mansoni	amine GPCR	0.1289	0.4186	0.4157
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus granulosus	orexin receptor type 2	0.1289	0.4186	1
Schistosoma mansoni	myosin xvIII	0.1289	0.4186	0.4157
Echinococcus multilocularis	neuropeptide s receptor	0.1289	0.4186	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.1289	0.4186	1
Echinococcus granulosus	dro:myosuppressin receptor	0.1289	0.4186	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.1289	0.4186	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1289	0.4186	1
Mycobacterium ulcerans	secreted antigen 85-C FbpC	0.0924	0.2985	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1289	0.4186	0.4157
Schistosoma mansoni	neuropeptide F-like receptor	0.1289	0.4186	0.4157
Onchocerca volvulus		0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	g protein coupled receptor	0.1289	0.4186	1
Echinococcus multilocularis	orexin receptor type 2	0.1289	0.4186	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.1289	0.4186	1
Echinococcus granulosus	G protein coupled receptor 139	0.1289	0.4186	1
Plasmodium falciparum	plasmepsin II	0.0059	0.0137	0.5
Schistosoma mansoni	biogenic amine receptor	0.1289	0.4186	0.4157
Brugia malayi	Dopamine receptor protein 2	0.1289	0.4186	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1289	0.4186	1
Brugia malayi	Dopamine receptor protein 1	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Schistosoma mansoni	opsin-like receptor	0.1289	0.4186	0.4157
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.1289	0.4186	0.4157
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.1289	0.4186	1
Brugia malayi	intermediate filament protein	0.0033	0.005	0.0119
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0034	0.0054	0.013
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1289	0.4186	1
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0072	0.0059
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.1289	0.4186	1
Schistosoma mansoni	neuropeptide receptor	0.1289	0.4186	0.4157
Echinococcus multilocularis	neuropeptide receptor	0.1289	0.4186	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.1289	0.4186	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.1289	0.4186	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.1289	0.4186	1
Brugia malayi	putative neuropeptide receptor NPR1	0.1289	0.4186	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.0515	0.0468
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0146	0.0097
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1289	0.4186	0.4157
Echinococcus granulosus	S formylglutathione hydrolase	0.0039	0.0072	0.0053
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0059	0.0137	0.021
Brugia malayi	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	neuropeptide receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1289	0.4186	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.1289	0.4186	1
Echinococcus granulosus	allatostatin A receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Onchocerca volvulus		0.1289	0.4186	1
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0072	0.0059
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1289	0.4186	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0146	0.0097
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.1289	0.4186	1
Echinococcus multilocularis	somatostatin receptor	0.1289	0.4186	1
Brugia malayi	neuropeptide F receptor	0.1289	0.4186	1
Onchocerca volvulus		0.1289	0.4186	1
Loa Loa (eye worm)	neuropeptide F receptor	0.1289	0.4186	1
Loa Loa (eye worm)	G-protein coupled receptor	0.1289	0.4186	1
Onchocerca volvulus		0.1289	0.4186	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.1289	0.4186	0.4157
Echinococcus granulosus	neuropeptides capa receptor	0.1289	0.4186	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.1289	0.4186	1
Echinococcus multilocularis	neuropeptide Y receptor	0.1289	0.4186	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.1289	0.4186	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1289	0.4186	1
Onchocerca volvulus		0.1289	0.4186	1
Onchocerca volvulus		0.1289	0.4186	1
Onchocerca volvulus		0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Brugia malayi	AKH receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0146	0.0349
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Brugia malayi	hypothetical protein	0.1289	0.4186	1
Loa Loa (eye worm)	TYRA-2 protein	0.1289	0.4186	1
Schistosoma mansoni	neuropeptide F-like receptor	0.1289	0.4186	0.4157
Echinococcus granulosus	tm gpcr rhodopsin	0.1289	0.4186	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.1289	0.4186	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1289	0.4186	0.4157
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.005	0.0119
Schistosoma mansoni	adenoreceptor	0.1289	0.4186	0.4157
Schistosoma mansoni	hypothetical protein	0.1289	0.4186	0.4157
Schistosoma mansoni	neuropeptide receptor	0.1289	0.4186	0.4157
Echinococcus granulosus	rhodopsin orphan GPCR	0.1289	0.4186	1
Echinococcus granulosus	sex peptide receptor	0.1289	0.4186	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.1289	0.4186	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.1289	0.4186	0.4157
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.1289	0.4186	1
Brugia malayi	follicle stimulating hormone receptor	0.1289	0.4186	1
Echinococcus multilocularis	g protein coupled receptor	0.1289	0.4186	1
Echinococcus multilocularis	allatostatin A receptor	0.1289	0.4186	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.1289	0.4186	0.4157
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Plasmodium vivax	aspartyl proteinase, putative	0.0059	0.0137	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1289	0.4186	0.4157
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.005	0.0119
Echinococcus granulosus	neuropeptide s receptor	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Onchocerca volvulus		0.1289	0.4186	1
Brugia malayi	hypothetical protein	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0137	0.0327
Brugia malayi	larval opioid receptor	0.1289	0.4186	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1289	0.4186	0.4157
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.005	0.0119
Brugia malayi	Serotonin receptor	0.1289	0.4186	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0146	0.0349
Brugia malayi	hypothetical protein	0.1289	0.4186	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.1289	0.4186	0.4157
Echinococcus granulosus	fmrfamide receptor	0.1289	0.4186	1
Echinococcus granulosus	g protein coupled receptor	0.1289	0.4186	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1289	0.4186	1
Leishmania major	cytochrome p450-like protein	0.0034	0.0054	0.5
Echinococcus granulosus	somatostatin receptor	0.1289	0.4186	1
Brugia malayi	RNA binding protein	0.0062	0.0146	0.0349
Brugia malayi	hypothetical protein	0.1289	0.4186	1
Loa Loa (eye worm)	hypothetical protein	0.1289	0.4186	1
Schistosoma mansoni	hypothetical protein	0.1289	0.4186	0.4157
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.1289	0.4186	1
Brugia malayi	hypothetical protein	0.1289	0.4186	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3392322

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1923435