Detailed information for compound 1924474

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 549.06 | Formula: C30H33ClN4O4
  • H donors: 2 H acceptors: 3 LogP: 4.23 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)c1ccc(cc1)N1CCN(CC1)C(=O)CN1CC[C@H](C1)C(=O)Nc1ccc(c(c1)Cl)O
  • InChi: 1S/C30H33ClN4O4/c1-39-26-9-4-22(5-10-26)21-2-7-25(8-3-21)34-14-16-35(17-15-34)29(37)20-33-13-12-23(19-33)30(38)32-24-6-11-28(36)27(31)18-24/h2-11,18,23,36H,12-17,19-20H2,1H3,(H,32,38)/t23-/m1/s1
  • InChiKey: IENGFJPUQKIIMW-HSZRJFAPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0162 1 1
Onchocerca volvulus Sepiapterin reductase homolog 0.0162 1 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0162 1 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0162 1 1
Plasmodium vivax steroid dehydrogenase, putative 0.0162 1 0.5
Brugia malayi hypothetical protein 0.0162 1 1
Leishmania major hypothetical protein, conserved 0.0162 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0162 1 0.5
Plasmodium falciparum steroid dehydrogenase, putative 0.0162 1 0.5
Giardia lamblia Reductase, putative 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Toxoplasma gondii oxidoreductase, putative 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0162 1 1
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0162 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0162 1 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0162 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0162 1 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0162 1 1
Leishmania major 3-keto-dihydrosphingosine reductase 0.0162 1 1
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0162 1 1
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0162 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Leishmania major hypothetical protein, conserved 0.0162 1 1
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0162 1 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0162 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0162 1 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Echinococcus granulosus steroid dehydrogenase 0.0162 1 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Echinococcus granulosus hypothetical protein 0.0162 1 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0162 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Onchocerca volvulus 0.0162 1 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0162 1 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0162 1 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0162 1 1
Echinococcus granulosus carbonyl reductase 1 0.0162 1 1
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0162 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0162 1 1
Brugia malayi dehydrogenases, short chain protein 2 0.0162 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0162 1 0.5
Onchocerca volvulus 0.0162 1 0.5
Plasmodium vivax hypothetical protein, conserved 0.0162 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Echinococcus multilocularis conserved hypothetical protein 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0162 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.0162 1 1
Echinococcus multilocularis steroid dehydrogenase 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0162 1 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0162 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0162 1 1
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0162 1 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0162 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0162 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0162 1 0.5
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0162 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Leishmania major short chain dehydrogenase-like protein 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Schistosoma mansoni carbonyl reductase 0.0162 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0162 1 0.5
Echinococcus granulosus WW domain containing oxidoreductase 0.0162 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0162 1 1
Brugia malayi Retinol dehydrogenase 12 0.0162 1 1
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0162 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0162 1 1
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0162 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0162 1 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0162 1 0.5
Onchocerca volvulus 0.0162 1 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0162 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0162 1 0.5
Echinococcus multilocularis retinol dehydrogenase 13 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0162 1 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0162 1 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0162 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Brugia malayi hypothetical protein 0.0162 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0162 1 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0162 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Leishmania major pteridine reductase 1 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0162 1 0.5
Leishmania major dehydrogenase-like protein 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0162 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0162 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0162 1 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0162 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Schistosoma mansoni carbonyl reductase 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0162 1 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0162 1 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0162 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0162 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0162 1 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0162 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Mycobacterium ulcerans dehydrogenase/reductase 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Schistosoma mansoni retinal dehydrogenase 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Echinococcus multilocularis oxidoreductase 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Leishmania major hypothetical protein, conserved 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0162 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0162 1 0.5
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0162 1 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0162 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0162 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0162 1 1
Brugia malayi oxidoreductase 0.0162 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Leishmania major short chain dehydrogenase, putative 0.0162 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Entamoeba histolytica hypothetical protein 0.0162 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Mycobacterium ulcerans oxidoreductase 0.0162 1 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0162 1 1
Loa Loa (eye worm) oxidoreductase 0.0162 1 1
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0162 1 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0162 1 1
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0162 1 1
Brugia malayi Dehydrogenases, short chain protein 30 0.0162 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0162 1 0.5
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0162 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Brugia malayi dehydrogenases, short chain protein 9 0.0162 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0162 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0162 1 0.5
Onchocerca volvulus 0.0162 1 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Toxoplasma gondii oxidoreductase, putative 0.0162 1 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0162 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Leishmania major short chain dehydrogenase, putative 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0162 1 1
Mycobacterium ulcerans short-chain type oxidoreductase 0.0162 1 0.5
Onchocerca volvulus 0.0162 1 0.5
Onchocerca volvulus 0.0162 1 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Leishmania major hypothetical protein, conserved 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0162 1 1
Giardia lamblia Hypothetical protein 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Echinococcus granulosus oxidoreductase 0.0162 1 1
Loa Loa (eye worm) dehydrogenase 0.0162 1 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0162 1 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0162 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0162 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0162 1 1
Loa Loa (eye worm) dehydrogenase 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Trichomonas vaginalis steroid dehydrogenase, putative 0.0162 1 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Schistosoma mansoni steroid dehydrogenase 0.0162 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Leishmania major oxidoreductase-like protein 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0162 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0162 1 0.5
Echinococcus granulosus carbonyl reductase 1 0.0162 1 1
Leishmania major hypothetical protein, conserved 0.0162 1 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.0162 1 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0162 1 1
Echinococcus granulosus hypothetical protein 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0162 1 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0162 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0162 1 0.5
Onchocerca volvulus 0.0162 1 0.5
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0162 1 1
Echinococcus granulosus carbonyl reductase 1 0.0162 1 1
Onchocerca volvulus 0.0162 1 0.5
Mycobacterium ulcerans oxidoreductase 0.0162 1 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0162 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0162 1 1
Mycobacterium ulcerans dehydrogenase 0.0162 1 0.5
Schistosoma mansoni carbonyl reductase 0.0162 1 1
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Trypanosoma brucei oxidoreductase-like protein 0.0162 1 1
Echinococcus granulosus retinol dehydrogenase 11 0.0162 1 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0162 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0162 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.0162 1 1
Mycobacterium leprae Probable oxidoreductase 0.0162 1 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0162 1 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 1 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0162 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0162 1 1
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0162 1 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.3 uM Inhibition of non-activated Erk2 (unknown origin) using activating Mek1 and peptide substrate by coupled Erk2 assay ChEMBL. 25716905
IC50 (binding) = 50 uM Inhibition of activated Erk2 (unknown origin) by biochemical assay ChEMBL. 25716905

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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