Detailed information for compound 1924651

Basic information

Technical information
  • TDR Targets ID: 1924651
  • Name: N-(5,7-dibromoquinolin-8-yl)cyclopropanesulfo namide
  • MW: 406.093 | Formula: C12H10Br2N2O2S
  • H donors: 1 H acceptors: 3 LogP: 3.09 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cc(Br)c2c(c1NS(=O)(=O)C1CC1)nccc2
  • InChi: 1S/C12H10Br2N2O2S/c13-9-6-10(14)12(11-8(9)2-1-5-15-11)16-19(17,18)7-3-4-7/h1-2,5-7,16H,3-4H2
  • InChiKey: GUYUSEFWQSDYES-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(5,7-dibromo-8-quinolyl)cyclopropanesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Brugia malayi sulfakinin receptor protein 0.0008 0.0175 0.0175
Brugia malayi hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0175 0.02
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Brugia malayi follicle stimulating hormone receptor 0.0008 0.0175 0.0175
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0008 0.0175 0.5
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 1 1
Schistosoma mansoni amine GPCR 0.0008 0.0175 0.02
Brugia malayi hypothetical protein 0.0008 0.0175 0.0175
Brugia malayi Tachykinin-like peptides receptor 99D 0.0008 0.0175 0.0175
Brugia malayi G protein-coupled receptor 0.0008 0.0175 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Brugia malayi hypothetical protein 0.0008 0.0175 0.0175
Echinococcus multilocularis dna polymerase eta 0.0023 0.6637 0.6577
Onchocerca volvulus 0.0008 0.0175 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0008 0.0175 0.02
Onchocerca volvulus 0.0008 0.0175 0.5
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.6637 0.7583
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Brugia malayi Dopamine receptor protein 1 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Trypanosoma brucei unspecified product 0.0023 0.6637 0.6637
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.365 0.365
Giardia lamblia DINP protein human, muc B family 0.0023 0.6637 0.6637
Schistosoma mansoni amine GPCR 0.0008 0.0175 0.02
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) TYRA-2 protein 0.0008 0.0175 0.0175
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0008 0.0175 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Brugia malayi G protein-coupled receptor F59B2.13 0.0008 0.0175 0.0175
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.6637 0.6637
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0008 0.0175 0.02
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0175 0.02
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.6637 1
Onchocerca volvulus 0.0008 0.0175 0.5
Brugia malayi Serotonin receptor 0.0008 0.0175 0.0175
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0175 0.0175
Brugia malayi putative neuropeptide receptor 0.0008 0.0175 0.0175
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.6637 0.6637
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0008 0.0175 0.02
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Onchocerca volvulus 0.0008 0.0175 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0008 0.0175 0.02
Echinococcus granulosus flap endonuclease 1 0.0031 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.6637 0.6577
Brugia malayi AKH receptor 0.0008 0.0175 0.0175
Schistosoma mansoni opsin-like receptor 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni alpha-1 adrenergic receptor 0.0008 0.0175 0.02
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0008 0.0175 0.02
Plasmodium vivax flap endonuclease 1, putative 0.0031 1 1
Onchocerca volvulus 0.0008 0.0175 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.365 0.365
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0008 0.0175 0.5
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.6637 0.6577
Schistosoma mansoni biogenic amine receptor 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0175 0.02
Brugia malayi GnHR receptor homolog 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.365 0.365
Brugia malayi hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0175 0.02
Brugia malayi Melatonin receptor type 1A 0.0008 0.0175 0.0175
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0175 0.02
Brugia malayi Dopamine receptor 0.0008 0.0175 0.0175
Loa Loa (eye worm) flap endonuclease-1 0.0031 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni amine GPCR 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Onchocerca volvulus 0.0008 0.0175 0.5
Onchocerca volvulus 0.0008 0.0175 0.5
Plasmodium falciparum flap endonuclease 1 0.0031 1 1
Onchocerca volvulus 0.0008 0.0175 0.5
Brugia malayi neuropeptide F receptor 0.0008 0.0175 0.0175
Giardia lamblia Flap structure-specific endonuclease 0.0031 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Brugia malayi hypothetical protein 0.0008 0.0175 0.0175
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.6637 0.6637
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.6637 0.6637
Brugia malayi Serotonin receptor 0.0008 0.0175 0.0175
Schistosoma mansoni DNA polymerase eta 0.0023 0.6637 0.7583
Echinococcus granulosus dna polymerase kappa 0.0023 0.6637 0.6577
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Brugia malayi larval opioid receptor 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0175 0.0175
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0175 0.02
Schistosoma mansoni amine GPCR 0.0008 0.0175 0.02
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0175 0.02
Brugia malayi hypothetical protein 0.0008 0.0175 0.0175
Echinococcus multilocularis flap endonuclease 1 0.0031 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.6637 0.6637
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.6637 1
Brugia malayi RE15519p 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Onchocerca volvulus 0.0008 0.0175 0.5
Onchocerca volvulus 0.0008 0.0175 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0008 0.0175 0.0175
Onchocerca volvulus 0.0008 0.0175 0.5
Brugia malayi ORL1-like opioid receptor 0.0008 0.0175 0.0175
Schistosoma mansoni amine GPCR 0.0008 0.0175 0.02
Onchocerca volvulus 0.0008 0.0175 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0008 0.0175 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Schistosoma mansoni hypothetical protein 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni biogenic amine receptor 0.0008 0.0175 0.02
Onchocerca volvulus 0.0008 0.0175 0.5
Schistosoma mansoni opsin-like receptor 0.0008 0.0175 0.02
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0175 0.02
Brugia malayi G-protein coupled receptor 0.0008 0.0175 0.0175
Schistosoma mansoni adenoreceptor 0.0008 0.0175 0.02
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0008 0.0175 0.0175
Onchocerca volvulus 0.0008 0.0175 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni neuropeptide f receptor 76f 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni neuropeptide receptor 0.0008 0.0175 0.02
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0175 0.02
Schistosoma mansoni neuropeptide receptor 0.0008 0.0175 0.02
Brugia malayi neuropeptide F receptor 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Entamoeba histolytica Flap nuclease, putative 0.0031 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0008 0.0175 0.0175
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0008 0.0175 0.0175
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0175 0.02
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.6637 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0175 0.02
Echinococcus granulosus dna polymerase eta 0.0023 0.6637 0.6577
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0008 0.0175 0.0175
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0008 0.0175 0.02
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0175 0.0175
Trypanosoma brucei unspecified product 0.0016 0.365 0.365
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.6637 0.6637
Schistosoma mansoni flap endonuclease-1 0.0028 0.8752 1
Schistosoma mansoni opsin-like receptor 0.0008 0.0175 0.02
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Brugia malayi hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni neuropeptide receptor 0.0008 0.0175 0.02
Onchocerca volvulus 0.0008 0.0175 0.5
Brugia malayi Dopamine receptor protein 2 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Schistosoma mansoni growth hormone secretagogue receptor 0.0008 0.0175 0.02
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0008 0.0175 0.0175
Brugia malayi hypothetical protein 0.0008 0.0175 0.0175
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0008 0.0175 0.0175
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.6637 0.6637
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.6637 0.6637
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni histamine h1 receptor 0.0008 0.0175 0.02
Schistosoma mansoni myosin xvIII 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Leishmania major DNA polymerase eta, putative 0.0023 0.6637 0.6637
Brugia malayi hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Echinococcus multilocularis dna polymerase kappa 0.0023 0.6637 0.6577
Loa Loa (eye worm) hypothetical protein 0.0023 0.6637 0.6637
Trypanosoma brucei unspecified product 0.0016 0.365 0.365
Schistosoma mansoni hypothetical protein 0.0008 0.0175 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Schistosoma mansoni biogenic amine receptor 0.0008 0.0175 0.02
Brugia malayi hypothetical protein 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni neuropeptide receptor 0.0008 0.0175 0.02
Loa Loa (eye worm) melatonin receptor type 1A 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0008 0.0175 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0175 0.02
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.6637 0.7583
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0175 0.02
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.6637 0.6637
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Brugia malayi putative neuropeptide receptor NPR1 0.0008 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Onchocerca volvulus 0.0008 0.0175 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.6637 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0175 0.02
Brugia malayi G-protein coupled receptor 0.0008 0.0175 0.0175
Leishmania major DNA polymerase kappa, putative 0.0023 0.6637 0.6637
Onchocerca volvulus 0.0008 0.0175 0.5
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0175 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0175 0.0175

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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