Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cat eye syndrome chromosome region, candidate 2 | Starlite/ChEMBL | References |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2A | Starlite/ChEMBL | References |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | zinc finger protein | 0.0052 | 0.0152 | 0.0209 |
Schistosoma mansoni | zinc finger protein | 0.0052 | 0.0152 | 0.0192 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.4252 | 0.4272 |
Schistosoma mansoni | bromodomain containing protein | 0.015 | 0.7918 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0052 | 0.0152 | 0.0209 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0081 | 0.2379 | 0.3267 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0142 | 0.7282 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.856 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2812 | 0.2359 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3912 | 0.3821 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0081 | 0.2379 | 0.3267 |
Brugia malayi | Bromodomain containing protein | 0.0094 | 0.3479 | 0.2673 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0142 | 0.7282 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 2 degrees C | Binding affinity to CECR2 (unknown origin) assessed as thermal shift at 10 uM by Real-Time PCR analysis | ChEMBL. | 25719566 |
Delta Tm (binding) | = 3.8 degrees C | Binding affinity to BAZ2B (unknown origin) assessed as thermal shift at 10 uM by Real-Time PCR analysis | ChEMBL. | 25719566 |
Delta Tm (binding) | = 5.2 degrees C | Binding affinity to BAZ2A (unknown origin) assessed as thermal shift at 10 uM by Real-Time PCR analysis | ChEMBL. | 25719566 |
F (ADMET) | = 70 % | Oral bioavailability in Balb/C mouse at 5 mg/kg | ChEMBL. | 25719566 |
IC50 (binding) | = 0.13 uM | Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 25719566 |
IC50 (binding) | = 0.18 uM | Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated peptide measured after 30 mins by AlphaScreen assay | ChEMBL. | 25719566 |
Kd (binding) | = 109 nM | Binding affinity to BAZ2A (unknown origin) by isothermal titration calorimetric analysis | ChEMBL. | 25719566 |
Kd (binding) | = 170 nM | Binding affinity to BAZ2B (unknown origin) by isothermal titration calorimetric analysis | ChEMBL. | 25719566 |
Kd (binding) | = 1.55 uM | Binding affinity to CECR2 (unknown origin) by isothermal titration calorimetric analysis | ChEMBL. | 25719566 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.