TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 592.449 | Formula: C29H19Cl2N3O5S
H donors: 3 H acceptors: 5 LogP: 6.63 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: S=C(c1ccc(cc1)c1ccc(o1)C(=O)O)NCc1ccc(cc1)c1cc(nn1c1ccc(c(c1)Cl)Cl)C(=O)O
InChi: 1S/C29H19Cl2N3O5S/c30-21-10-9-20(13-22(21)31)34-24(14-23(33-34)28(35)36)17-3-1-16(2-4-17)15-32-27(40)19-7-5-18(6-8-19)25-11-12-26(39-25)29(37)38/h1-14H,15H2,(H,32,40)(H,35,36)(H,37,38)
InChiKey: KWYNKWNVQJPKES-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	replication protein A1, 70kDa	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Cryptosporidium hominis	replication protein A 70kDa	Get druggable targets OG5_127539	All targets in OG5_127539
Loa Loa (eye worm)	replication factor A 73 kDa subunit	Get druggable targets OG5_127539	All targets in OG5_127539
Onchocerca volvulus	Putative replication factor A 73 kDa subunit	Get druggable targets OG5_127539	All targets in OG5_127539
Trypanosoma brucei gambiense	replication factor A, 51kDa subunit, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Trichomonas vaginalis	replication factor A 1, rfa1, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Cryptosporidium parvum	Rf-A (OB fold protein)	Get druggable targets OG5_127539	All targets in OG5_127539
Plasmodium yoelii	putative replication A protein	Get druggable targets OG5_127539	All targets in OG5_127539
Leishmania major	replication factor A, 51kDa subunit, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Schistosoma japonicum	ko:K07466 replication factor A1, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Trypanosoma brucei	Replication factor A protein 1	Get druggable targets OG5_127539	All targets in OG5_127539
Trichomonas vaginalis	replication factor A 1, rfa1, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Leishmania braziliensis	replication factor A, 51kDa subunit, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Trichomonas vaginalis	replication factor A 1, rfa1, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Plasmodium falciparum	replication protein A1, large subunit	Get druggable targets OG5_127539	All targets in OG5_127539
Plasmodium vivax	replication protein A1, large subunit, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Babesia bovis	replication factor-a protein 1 (rpa1) family protein	Get druggable targets OG5_127539	All targets in OG5_127539
Trypanosoma cruzi	Replication factor A protein 1	Get druggable targets OG5_127539	All targets in OG5_127539
Neospora caninum	hypothetical protein	Get druggable targets OG5_127539	All targets in OG5_127539
Echinococcus granulosus	replication protein A 70 kDa DNA binding	Get druggable targets OG5_127539	All targets in OG5_127539
Leishmania mexicana	replication factor A, 51kDa subunit, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Trichomonas vaginalis	replication factor A 1, rfa1, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Entamoeba histolytica	replication factor A protein 1, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Schistosoma mansoni	replication factor A 1 rfa1	Get druggable targets OG5_127539	All targets in OG5_127539
Candida albicans	similar to single-stranded DNA binding protein involved in DNA-damage repair	Get druggable targets OG5_127539	All targets in OG5_127539
Trypanosoma congolense	Replication factor A protein 1	Get druggable targets OG5_127539	All targets in OG5_127539
Echinococcus multilocularis	replication protein A 70 kDa DNA binding	Get druggable targets OG5_127539	All targets in OG5_127539
Plasmodium knowlesi	replication protein A1, large subunit, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Candida albicans	similar to single-stranded DNA binding protein involved in DNA-damage repair	Get druggable targets OG5_127539	All targets in OG5_127539
Leishmania donovani	Replication factor A protein 1	Get druggable targets OG5_127539	All targets in OG5_127539
Brugia malayi	replication factor A 73 kDa subunit	Get druggable targets OG5_127539	All targets in OG5_127539
Leishmania infantum	replication factor A, 51kDa subunit, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Theileria parva	replication factor A protein, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Plasmodium berghei	replication protein A1, large subunit, putative	Get druggable targets OG5_127539	All targets in OG5_127539
Toxoplasma gondii	replication factor-a protein 1 (rpa1) subfamily protein	Get druggable targets OG5_127539	All targets in OG5_127539

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.4346	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.2195	0.1791
Plasmodium falciparum	replication protein A1, large subunit	0.002	0.1507	0.1067
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Giardia lamblia	Cathepsin L precursor	0.0014	0.0492	0.5
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0075	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0075	1	1
Brugia malayi	Cathepsin L-like precursor	0.0075	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0038	0.4346	0.4054
Loa Loa (eye worm)	ctsf protein	0.0075	1	1
Toxoplasma gondii	cathepsin CPC2	0.0014	0.0492	0.0492
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.2195	0.1791
Trypanosoma cruzi	cysteine peptidase, putative	0.0075	1	1
Entamoeba histolytica	cysteine protease, putative	0.0075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.2195	0.1791
Toxoplasma gondii	cathepsin CPC1	0.0014	0.0492	0.0492
Giardia lamblia	Cysteine protease	0.0014	0.0492	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	1	1
Giardia lamblia	Cathepsin L precursor	0.0014	0.0492	0.5
Onchocerca volvulus		0.0075	1	1
Plasmodium vivax	vivapain-1	0.0038	0.4346	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0038	0.4346	0.4054
Leishmania major	cathepsin L-like protease	0.0075	1	1
Plasmodium vivax	vivapain-2	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Loa Loa (eye worm)	hypothetical protein	0.0075	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0038	0.4346	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Leishmania major	cathepsin L-like protease	0.0075	1	1
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Giardia lamblia	Cathepsin B precursor	0.0014	0.0492	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0075	1	1
Onchocerca volvulus		0.005	0.6145	0.5946
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0014	0.0492	0.5
Giardia lamblia	Cysteine protease	0.0014	0.0492	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.4346	0.4054
Onchocerca volvulus		0.0075	1	1
Giardia lamblia	Cathepsin L precursor	0.0014	0.0492	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0075	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0075	1	1
Leishmania major	cathepsin L-like protease	0.0075	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0038	0.4346	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Entamoeba histolytica	replication factor A protein 1, putative	0.0018	0.1181	0.0725
Trypanosoma cruzi	cysteine proteinase, putative	0.0038	0.4346	0.4054
Giardia lamblia	Cathepsin B precursor	0.0014	0.0492	0.5
Giardia lamblia	Cathepsin L precursor	0.0014	0.0492	0.5
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Brugia malayi	Cathepsin L-like precursor	0.005	0.6145	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Echinococcus multilocularis	cathepsin L	0.0038	0.4346	0.4054
Echinococcus multilocularis	replication protein A 70 kDa DNA binding	0.0042	0.4946	0.4685
Echinococcus multilocularis	cathepsin L cysteine protease	0.0075	1	1
Brugia malayi	Cathepsin L-like precursor	0.0075	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0038	0.4346	0.4054
Onchocerca volvulus		0.0075	1	1
Giardia lamblia	Cysteine protease	0.0014	0.0492	0.5
Brugia malayi	Cathepsin L-like precursor	0.005	0.6145	0.5946
Toxoplasma gondii	cathepsin B	0.0014	0.0492	0.0492
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.005	0.6145	0.5946
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.004	0.462	0.4342
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0075	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0038	0.4346	0.4054
Giardia lamblia	Cathepsin B precursor	0.0014	0.0492	0.5
Plasmodium vivax	vivapain-3	0.0038	0.4346	0.4054
Toxoplasma gondii	replication factor-a protein 1 (rpa1) subfamily protein	0.002	0.1507	0.1507
Loa Loa (eye worm)	replication factor A 73 kDa subunit	0.0042	0.4946	0.4685
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0038	0.4346	0.4054
Schistosoma mansoni	replication factor A 1 rfa1	0.0042	0.4946	0.4685
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.6145	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.4346	0.4054
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0042	0.4946	0.4685
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	1	1
Leishmania major	replication factor A, 51kDa subunit, putative	0.002	0.1507	0.1067
Giardia lamblia	Cathepsin L-like protease	0.0014	0.0492	0.5
Plasmodium vivax	vivapain-2	0.0075	1	1
Giardia lamblia	Cathepsin B precursor	0.0014	0.0492	0.5
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0075	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.005	0.6145	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.4346	0.4054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.6145	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	1	1
Leishmania major	cathepsin L-like protease	0.0075	1	1
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0075	1	1
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Loa Loa (eye worm)	cysteine protease	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Onchocerca volvulus		0.0075	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0038	0.4346	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	1	1
Brugia malayi	replication factor A 73 kDa subunit	0.0042	0.4946	0.4685
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0075	1	1
Plasmodium vivax	unspecified product	0.0038	0.4346	0.4054
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0014	0.0492	0.5
Brugia malayi	cathepsin L-like precursor	0.005	0.6145	0.5946
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0025	0.2195	0.1791
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0075	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0025	0.2195	0.1791
Entamoeba histolytica	cysteine proteinase, putative	0.0038	0.4346	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0075	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.005	0.6145	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0075	1	1
Leishmania major	cathepsin L-like protease	0.0075	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0075	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0075	1	1
Leishmania major	cathepsin L-like protease	0.0075	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0038	0.4346	0.4054
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0014	0.0492	0.0492
Leishmania major	cysteine peptidase A (CPA)	0.0075	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0075	1	1
Echinococcus multilocularis	cysteine protease	0.0075	1	1
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0025	0.2195	0.1791
Giardia lamblia	Hypothetical protein	0.0014	0.0492	0.5
Giardia lamblia	Cathepsin L-like protease	0.0014	0.0492	0.5
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0042	0.4946	0.4685
Echinococcus granulosus	cysteine protease	0.0038	0.4346	0.4054
Trypanosoma brucei	Replication factor A protein 1	0.002	0.1507	0.1067
Loa Loa (eye worm)	hypothetical protein	0.005	0.6145	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0038	0.4346	0.4054
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.002	0.1507	0.1067
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0075	1	1
Giardia lamblia	Hypothetical protein	0.0014	0.0492	0.5
Echinococcus granulosus	cathepsin L	0.0038	0.4346	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0025	0.2195	0.1791
Trypanosoma cruzi	Replication factor A protein 1	0.002	0.1507	0.1067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	1	1
Loa Loa (eye worm)	fibroinase	0.0075	1	1
Echinococcus multilocularis	cysteine protease	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0075	1	1
Giardia lamblia	Cathepsin B precursor	0.0014	0.0492	0.5
Echinococcus granulosus	cathepsin l1	0.0075	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0025	0.2195	0.1791
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0075	1	1
Echinococcus granulosus	cathepsin l1	0.005	0.6145	0.5946
Onchocerca volvulus		0.0075	1	1
Onchocerca volvulus		0.0075	1	1
Plasmodium vivax	unspecified product	0.0025	0.2195	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0075	1	1
Giardia lamblia	Cysteine protease	0.0014	0.0492	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.6145	0.5946
Plasmodium vivax	replication protein A1, large subunit, putative	0.002	0.1507	0.1067
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0014	0.0492	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Echinococcus granulosus	replication protein A 70 kDa DNA binding	0.0042	0.4946	0.4685
Schistosoma mansoni	cathepsin s	0.0025	0.2195	0.1791
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.2195	0.1791
Brugia malayi	Cathepsin L-like precursor	0.0075	1	1
Giardia lamblia	Cathepsin B precursor	0.0014	0.0492	0.5
Trypanosoma cruzi	cysteine protease, putative	0.0038	0.4346	0.4054
Loa Loa (eye worm)	hypothetical protein	0.005	0.6145	0.5946
Entamoeba histolytica	cysteine proteinase, putative	0.0075	1	1
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0038	0.4346	0.4054
Echinococcus granulosus	cathepsin L cysteine protease	0.0038	0.4346	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0075	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0075	1	1
Giardia lamblia	Cathepsin B precursor	0.0014	0.0492	0.5
Trypanosoma cruzi	cruzipain precursor, putative	0.0075	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0075	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0038	0.4346	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Onchocerca volvulus	Putative replication factor A 73 kDa subunit	0.0038	0.4252	0.3955
Brugia malayi	Cathepsin L-like precursor	0.0075	1	1
Giardia lamblia	Cathepsin L precursor	0.0014	0.0492	0.5
Toxoplasma gondii	cathepsin CPL	0.0075	1	1
Leishmania major	cathepsin L-like protease	0.0075	1	1
Leishmania major	cathepsin L-like protease	0.0075	1	1
Onchocerca volvulus		0.0075	1	1
Brugia malayi	Cathepsin L-like precursor	0.0075	1	1
Giardia lamblia	Encystation-specific protease	0.0014	0.0492	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0038	0.4346	0.4054
Giardia lamblia	Cathepsin L precursor	0.0014	0.0492	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0075	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0014	0.0492	0.5
Brugia malayi	Cathepsin L-like cysteine proteinase	0.005	0.6145	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0038	0.4346	0.4054
Entamoeba histolytica	cysteine proteinase 2	0.0038	0.4346	0.4054
Giardia lamblia	Cathepsin B precursor	0.0014	0.0492	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 0.55 nM	Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisotropy assay	ChEMBL.	25699140

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3422469

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1931028