Detailed information for compound 1931238

Basic information

Technical information
  • TDR Targets ID: 1931238
  • Name: 6-methoxy-2-[(4-methoxyphenyl)methylidene]-1- benzofuran-3-one
  • MW: 282.291 | Formula: C17H14O4
  • H donors: 0 H acceptors: 1 LogP: 3.54 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C/1\Oc2c(C1=O)ccc(c2)OC
  • InChi: 1S/C17H14O4/c1-19-12-5-3-11(4-6-12)9-16-17(18)14-8-7-13(20-2)10-15(14)21-16/h3-10H,1-2H3/b16-9-
  • InChiKey: LNLRZAXYLVIPKL-SXGWCWSVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2Z)-6-methoxy-2-[(4-methoxyphenyl)methylidene]-1-benzofuran-3-one
  • 6-methoxy-2-[(4-methoxyphenyl)methylene]benzofuran-3-one
  • (2Z)-6-methoxy-2-[(4-methoxyphenyl)methylene]benzofuran-3-one
  • 6-methoxy-2-[(4-methoxyphenyl)methylene]-3-benzofuranone
  • (2Z)-6-methoxy-2-[(4-methoxyphenyl)methylene]-3-benzofuranone
  • (2Z)-6-methoxy-2-(4-methoxybenzylidene)benzofuran-3-one
  • 6-methoxy-2-(4-methoxybenzylidene)benzofuran-3-one
  • ZINC00489748
  • 6-methoxy-2-(4-methoxybenzylidene)-1-benzofuran-3(2H)-one
  • AK-087/11270012
  • STOCK1N-41635

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0036 0.0703 1
Loa Loa (eye worm) TAR-binding protein 0.0126 0.3028 0.5098
Brugia malayi M-phase phosphoprotein, mpp8 0.0025 0.0419 0.0705
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3028 0.2984
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0063 0.006
Schistosoma mansoni hypothetical protein 0.005 0.1061 0.1004
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0703 0.1279
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0411 0.157
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0411 0.157
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.02 0.0138
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0138 0.0232
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0703 0.0807
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.5672 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0025 0.0419 0.0705
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0267 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0703 0.1279
Treponema pallidum NADH oxidase 0.0019 0.0267 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.1965 0.498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0952 0.0895
Plasmodium falciparum heterochromatin protein 1 0.0025 0.0419 0.1658
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.3336 0.5678
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0419 0.0445
Echinococcus granulosus GPCR family 2 0.005 0.1061 0.1059
Echinococcus multilocularis geminin 0.0168 0.4121 0.4119
Loa Loa (eye worm) RNA binding protein 0.0126 0.3028 0.5098
Echinococcus granulosus chromobox protein 1 0.0151 0.3678 0.3676
Echinococcus granulosus Chromobox protein 3 0.0025 0.0419 0.0416
Brugia malayi CXXC zinc finger family protein 0.0028 0.0498 0.0839
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.02 0.0333
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.2547 0.429
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0411 0.157
Echinococcus multilocularis smad 0.0016 0.02 0.0198
Plasmodium falciparum thioredoxin reductase 0.0054 0.1183 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0581 0.0922
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3028 0.2984
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.02 0.0198
Schistosoma mansoni chromobox protein 0.0025 0.0419 0.0358
Echinococcus multilocularis Smad4 0.0016 0.02 0.0198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0952 0.095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0581 0.0922
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0091 0.2131 1
Echinococcus granulosus Chromo domain 0.0025 0.0419 0.0416
Brugia malayi glutathione reductase 0.0054 0.1183 0.1993
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.046 0.0457
Trichomonas vaginalis chromobox protein, putative 0.0151 0.3678 1
Plasmodium vivax glutathione reductase, putative 0.0054 0.1183 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.3336 0.5678
Schistosoma mansoni cpg binding protein 0.0029 0.0539 0.0479
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.1183 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0703 0.4761
Loa Loa (eye worm) hypothetical protein 0.0025 0.0419 0.0701
Schistosoma mansoni hypothetical protein 0.0168 0.4121 0.4083
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.3827 0.6447
Leishmania major hypothetical protein, conserved 0.0036 0.0703 0.4761
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0849 0.6045
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0267 0.0264
Mycobacterium tuberculosis Probable dehydrogenase 0.0124 0.2979 0.5018
Plasmodium vivax heterochromatin protein 1, putative 0.0025 0.0419 0.1658
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.02 0.0198
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.046 0.0457
Schistosoma mansoni Smad4 0.0016 0.02 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0952 0.0895
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0267 0.5
Brugia malayi chromobox protein homolog 3 0.0085 0.1965 0.331
Onchocerca volvulus 0.0028 0.0498 0.0466
Echinococcus multilocularis GPCR, family 2 0.005 0.1061 0.1059
Mycobacterium ulcerans beta-lactamase 0.0036 0.0703 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0419 0.0445
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.3411 0.341
Loa Loa (eye worm) hypothetical protein 0.0066 0.1493 0.2512
Brugia malayi beta-lactamase family protein 0.0036 0.0703 0.1184
Brugia malayi MH1 domain containing protein 0.0016 0.02 0.0337
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.1183 0.118
Brugia malayi hypothetical protein 0.0016 0.0187 0.0316
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.1061 0.1059
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0419 0.1658
Onchocerca volvulus 0.0036 0.0703 0.1661
Brugia malayi SET domain containing protein 0.0025 0.0434 0.0731
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0703 0.1279
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0419 0.0445
Echinococcus multilocularis chromobox protein 1 0.0151 0.3678 0.3676
Echinococcus granulosus tar DNA binding protein 0.0126 0.3028 0.3026
Brugia malayi MH1 domain containing protein 0.0016 0.02 0.0337
Schistosoma mansoni smad1 5 8 and 0.0016 0.02 0.0138
Trichomonas vaginalis hypothetical protein 0.0025 0.0419 0.0445
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0419 0.1578
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0703 0.0807
Schistosoma mansoni hypothetical protein 0.005 0.1061 0.1004
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0419 0.0445
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0703 0.1279
Loa Loa (eye worm) hypothetical protein 0.0107 0.2547 0.4287
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0267 0.0205
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0703 0.0807
Echinococcus granulosus chromobox protein 2 0.0025 0.0419 0.0416
Brugia malayi MH2 domain containing protein 0.0016 0.02 0.0337
Echinococcus multilocularis dnaJ subfamily B 0.0396 1 1
Echinococcus granulosus chromobox protein 1 0.0151 0.3678 0.3676
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0952 0.0895
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0506 0.0701
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0703 0.4761
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0419 0.0445
Loa Loa (eye worm) hypothetical protein 0.0085 0.1965 0.3307
Brugia malayi Valyl-tRNA synthetase 0.0025 0.0419 0.0705
Loa Loa (eye worm) hypothetical protein 0.0024 0.0411 0.0687
Loa Loa (eye worm) hypothetical protein 0.0036 0.0703 0.118
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.1183 0.1989
Loa Loa (eye worm) Smad1 0.0016 0.02 0.0333
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.3028 0.5098
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0703 0.4761
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.046 0.077
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0025 0.0419 0.0416
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0952 0.095
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.3336 1
Loa Loa (eye worm) nuclear factor I 0.0009 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0419 0.0701
Schistosoma mansoni hypothetical protein 0.0107 0.2547 0.25
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0581 0.0922
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0419 0.0358
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.02 0.0333
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0411 0.157
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.1061 0.1787
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1303 0.1247
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.331 0.3308
Trichomonas vaginalis conserved hypothetical protein 0.006 0.1327 0.311
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0124 0.2979 0.8645
Echinococcus granulosus Smad4 0.0016 0.02 0.0198
Toxoplasma gondii thioredoxin reductase 0.0054 0.1183 0.952
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.1183 0.118
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0703 0.1279
Loa Loa (eye worm) glutathione reductase 0.0054 0.1183 0.1989
Echinococcus multilocularis chromobox protein 1 0.0151 0.3678 0.3676
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0506 0.0701
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0419 0.1578
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0063 0.006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0494 0.0666
Brugia malayi MH1 domain containing protein 0.0009 0.0013 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0419 0.0445
Loa Loa (eye worm) hypothetical protein 0.0036 0.0703 0.118
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0581 0.0922
Plasmodium falciparum glutathione reductase 0.0054 0.1183 1
Brugia malayi MH1 domain containing protein 0.0009 0.0013 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3028 0.2984
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.1965 0.498
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.3827 0.6445
Mycobacterium tuberculosis Probable reductase 0.0124 0.2979 0.5018
Brugia malayi beta-lactamase family protein 0.0036 0.0703 0.1184
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0419 0.0445
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.076 1
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0419 0.0445
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0267 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0419 0.0445
Loa Loa (eye worm) helicase 0.0025 0.0419 0.0701
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0581 0.0922
Brugia malayi RNA binding protein 0.0126 0.3028 0.51
Brugia malayi CHD4 protein 0.0026 0.046 0.0774
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0419 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0419 0.0445
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.1061 0.1783
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0849 0.1706
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0849 0.1706
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0703 0.0807
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.1061 0.1059
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0419 0.0358
Schistosoma mansoni hypothetical protein 0.0025 0.0419 0.0358
Leishmania major hypothetical protein, conserved 0.0024 0.0411 0.157
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0411 0.157
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.3411 0.5746
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0703 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0581 0.0922
Trypanosoma brucei trypanothione reductase 0.0054 0.1183 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.3411 0.337
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0124 0.2979 0.5018
Brugia malayi TAR-binding protein 0.0126 0.3028 0.51
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0703 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0419 0.0701
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0581 0.0922
Loa Loa (eye worm) hypothetical protein 0.0036 0.0703 0.118
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0267 0.5
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.076 1
Schistosoma mansoni chromobox protein 0.0151 0.3678 0.3637
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0952 0.16
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.1183 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0703 0.07
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0124 0.2979 0.5018
Echinococcus multilocularis Chromo domain 0.0025 0.0419 0.0416
Schistosoma mansoni smad1 5 8 and 0.0016 0.02 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.006 0.1327 0.311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0703 0.0644
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.3028 0.51
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.3827 0.6447
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0025 0.0419 0.1578
Mycobacterium tuberculosis Conserved protein 0.0036 0.0703 0.0807
Trichomonas vaginalis esterase, putative 0.0036 0.0703 0.1279
Onchocerca volvulus 0.0066 0.1493 0.6276
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0703 0.07
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3028 0.2984
Onchocerca volvulus 0.0036 0.0703 0.1661
Leishmania major trypanothione reductase 0.0054 0.1183 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0703 0.0807
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.5937 1
Schistosoma mansoni chromobox protein 0.0025 0.0419 0.0358
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0419 0.1658
Brugia malayi beta-lactamase 0.0036 0.0703 0.1184
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0498 0.0835
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0267 0.0449
Brugia malayi Smad1 0.0016 0.02 0.0337
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0411 0.157
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0419 0.0445
Loa Loa (eye worm) hypothetical protein 0.0036 0.0703 0.118
Echinococcus granulosus smad 0.0016 0.02 0.0198
Trichomonas vaginalis chromobox protein, putative 0.0151 0.3678 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0124 0.2979 0.5018
Mycobacterium tuberculosis Conserved protein 0.0036 0.0703 0.0807
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0124 0.2979 0.5018
Brugia malayi Thioredoxin reductase 0.0054 0.1183 0.1993
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3028 0.2984
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0952 0.095
Loa Loa (eye worm) hypothetical protein 0.0036 0.0703 0.118
Trichomonas vaginalis chromobox protein, putative 0.0091 0.2131 0.5466
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0952 0.1604
Schistosoma mansoni hypothetical protein 0.005 0.1061 0.1004
Schistosoma mansoni chromobox protein 0.0151 0.3678 0.3637
Schistosoma mansoni hypothetical protein 0.0168 0.4121 0.4083
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.02 0.0198
Mycobacterium ulcerans lipase LipD 0.0036 0.0703 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0085 0.1965 0.9031
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0703 0.0807
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.5937 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0703 0.118
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0419 0.1658
Loa Loa (eye worm) hypothetical protein 0.005 0.1061 0.1783
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.1061 0.1059
Schistosoma mansoni cpg binding protein 0.0029 0.0539 0.0479
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.0419 0.0705
Onchocerca volvulus 0.0036 0.0703 0.1661
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0703 0.118
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0419 0.0445
Onchocerca volvulus 0.0025 0.0434 0.0092
Brugia malayi Latrophilin receptor protein 2 0.005 0.1061 0.1787
Schistosoma mansoni hypothetical protein 0.0396 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0952 0.095
Schistosoma mansoni hypothetical protein 0.005 0.1061 0.1004
Schistosoma mansoni smad1 5 8 and 0.0016 0.02 0.0138
Loa Loa (eye worm) heterochromatin protein 1 0.0151 0.3678 0.6192
Echinococcus granulosus cpg binding protein 0.0029 0.0539 0.0537
Loa Loa (eye worm) hypothetical protein 0.0157 0.3827 0.6445
Echinococcus multilocularis Chromobox protein 3 0.0025 0.0419 0.0416
Loa Loa (eye worm) acetyltransferase 0.0141 0.3411 0.5744
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0703 0.0807
Loa Loa (eye worm) hypothetical protein 0.0025 0.0419 0.0701
Loa Loa (eye worm) hypothetical protein 0.0025 0.0419 0.0701
Brugia malayi Protein cec-1. 0.0025 0.0419 0.0705
Loa Loa (eye worm) hypothetical protein 0.0025 0.0419 0.0701
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0411 0.1495
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0419 0.0445
Echinococcus granulosus geminin 0.0168 0.4121 0.4119
Brugia malayi Heterochromatin protein 1 0.0151 0.3678 0.6194
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1229 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0419 0.0701
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.046 0.0399
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0849 0.6045
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0025 0.0419 0.1658
Loa Loa (eye worm) hypothetical protein 0.0036 0.0703 0.118
Toxoplasma gondii ABC1 family protein 0.0036 0.0703 0.4533
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0849 0.0846
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.076 0.5379
Schistosoma mansoni smad 0.0016 0.02 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0703 0.4761
Trichomonas vaginalis chromobox protein, putative 0.0091 0.2131 0.5466
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0703 0.1184
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0025 0.0419 0.0416
Mycobacterium tuberculosis Conserved protein 0.0036 0.0703 0.0807
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.3336 0.5678
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.1061 0.1059
Brugia malayi hypothetical protein 0.0024 0.0411 0.0692
Brugia malayi hypothetical protein 0.0025 0.0419 0.0705
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0138 0.0232
Schistosoma mansoni cpg binding protein 0.0028 0.0498 0.0438
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.02 0.0198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0703 0.0644
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0025 0.0434 0.0373
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.1183 0.1695
Trichomonas vaginalis Heterochromatin protein, putative 0.0025 0.0419 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0419 0.0445
Brugia malayi MH2 domain containing protein 0.0016 0.02 0.0337
Echinococcus multilocularis tar DNA binding protein 0.0126 0.3028 0.3026
Brugia malayi MH2 domain containing protein 0.0239 0.5937 1
Echinococcus multilocularis cpg binding protein 0.0029 0.0539 0.0537
Echinococcus multilocularis chromobox protein 2 0.0025 0.0419 0.0416
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0849 0.635
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0581 0.0922

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100 uM Inhibition of electric eel AChE incubated for 15 mins using acetylcholine iodide substrate by colorimetric Ellman's method ChEMBL. 25768702
IC50 (binding) > 100 uM Inhibition of equine serum butyrylcholine esterase incubated for 15 mins using S-butyrylthiocholine chloride substrate by colorimetric Ellman's method ChEMBL. 25768702

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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