Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0278 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0157 | 0.5523 | 0.5523 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0212 | 0.0212 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0026 | 0.0736 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0212 | 0.0212 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.0212 | 0.0212 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0212 | 0.0212 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | carboxylesterase | 0.0026 | 0.0736 | 0.0736 |
Echinococcus multilocularis | acetylcholinesterase | 0.0157 | 0.5523 | 0.5523 |
Echinococcus granulosus | carboxylesterase 5A | 0.0157 | 0.5523 | 0.5523 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.0212 | 0.0212 |
Echinococcus multilocularis | neuroligin | 0.0026 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.0212 | 0.0212 |
Onchocerca volvulus | 0.0026 | 0.0736 | 1 | |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0212 | 0.0212 |
Onchocerca volvulus | 0.0026 | 0.0736 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0026 | 0.0736 | 0.0736 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0212 | 0.0212 |
Schistosoma mansoni | gliotactin | 0.0026 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0736 | 0.0736 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0212 | 0.0212 |
Echinococcus granulosus | neuroligin | 0.0026 | 0.0736 | 0.0736 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0212 | 0.0212 |
Echinococcus granulosus | acetylcholinesterase | 0.0157 | 0.5523 | 0.5523 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0736 | 0.0736 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0026 | 0.0736 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0157 | 0.5523 | 0.5523 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0026 | 0.0736 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0736 | 0.0736 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0212 | 0.0212 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0026 | 0.0736 | 0.0736 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0212 | 0.0212 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0157 | 0.5523 | 0.5523 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0157 | 0.5523 | 0.5523 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0212 | 0.0212 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.0736 | 0.0736 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.0736 | 0.0736 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0026 | 0.0736 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.5523 | 0.5523 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0278 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.5523 | 0.5523 |
Echinococcus granulosus | acetylcholinesterase | 0.0157 | 0.5523 | 0.5523 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0026 | 0.0736 | 0.0736 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0212 | 0.0212 |
Echinococcus multilocularis | acetylcholinesterase | 0.0157 | 0.5523 | 0.5523 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.0212 | 0.0212 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0026 | 0.0736 | 0.0736 |
Schistosoma mansoni | acetylcholinesterase | 0.0026 | 0.0736 | 0.0736 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0026 | 0.0736 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0026 | 0.0736 | 0.0736 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0026 | 0.0736 | 0.0736 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0026 | 0.0736 | 0.0736 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0026 | 0.0736 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.0736 | 0.0736 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.0212 | 0.0212 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.0212 | 0.0212 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0212 | 0.0212 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0278 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0212 | 0.0212 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0212 | 0.0212 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0736 | 0.0736 |
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.0736 | 0.0736 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.0212 | 0.0212 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0212 | 0.0212 |
Onchocerca volvulus | 0.0026 | 0.0736 | 1 | |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0212 | 0.0212 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.0212 | 0.0212 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0026 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0736 | 0.0736 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0212 | 0.0212 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0026 | 0.0736 | 0.0736 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | carboxylesterase | 0.0026 | 0.0736 | 0.0736 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | Carboxylesterase family protein | 0.0157 | 0.5523 | 0.5523 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0212 | 0.0212 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0212 | 0.0212 |
Onchocerca volvulus | 0.0026 | 0.0736 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0026 | 0.0736 | 0.0736 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0278 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0157 | 0.5523 | 0.5523 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0212 | 0.0212 |
Onchocerca volvulus | 0.0026 | 0.0736 | 1 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0736 | 0.0736 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0212 | 0.0212 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0212 | 0.0212 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.0212 | 0.0212 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0026 | 0.0736 | 0.0736 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.0212 | 0.0212 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.0212 | 0.0212 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0212 | 0.0212 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.0212 | 0.0212 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Stabilty (ADMET) | = 0 % | Metabolic stability assessed as human recombinant CYP3A4-mediated stability measured as compound remaining at 1 uM after 1 hr by LC-MS analysis | ChEMBL. | 25847770 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.